Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
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Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Case report
Year : 2024 | Month : April | Volume : 18 | Issue : 4 | Page : OD05 - OD07 Full Version

Crossed Fused Ectopic Kidney with Stone Disease and Bifid Renal Pelvis: A Case Report


Published: April 1, 2024 | DOI: https://doi.org/10.7860/JCDR/2024/68368.19266
Vikram Satav, Ashish Gavade, Vilas Sabale, Sunil Mhaske, Shashikant Asabe

1. Professor, Department of Urology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India. 2. Resident, Department of Urology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India. 3. Professor, Department of Urology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India. 4. Associate Professor, Department of Urology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India. 5. Assistant Professor, Department of Urology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.

Correspondence Address :
Dr. Ashish Gavade,
Resident, Department of Urology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Sant Tukaram Nagar, Pimpri, Pune-411018, Maharashtra, India.
E-mail: ashishg0208@gmail.com

Abstract

Crossed fused ectopic kidney is a rare congenital anomaly wherein the kidneys are present on the same side due to fusion. It is a rare disease that may remain undiagnosed throughout life. Its rarity and anatomical abnormality make any intervention challenging. A 32-year-old male patient presented with symptoms of pain in the abdomen and burning micturition for a year. Serum creatinine, along with other blood tests, was normal. X-ray KUB showed renal calculi in the region of the right kidney. However, a Computed Tomography (CT) scan showed that the left kidney was malrotated and fused with the lower pole of the right kidney, suggestive of crossed fused renal ectopia. A cystoscopy and retrograde pyelography were performed, followed by open pyelolithotomy, wherein calculi were removed, and a stent was placed. Through this case report, it is suggested that adequate presurgery evaluation is necessary for patients with such malformations.

Keywords

Congenital kidney disease, Fusion anomaly, Multiple calculi, Retrograde pyelography

Case Report

A 32-year-old male presented with pain in the right-side of the abdomen and burning micturition for a year. The pain was intermittent and was relieved after taking medications. There was no history of dysuria, lithuria, haematuria, Lower Urinary Tract Symptoms (LUTS), or fever. There was no history of similar complaints in the past. The patient hadn’t undergone any surgeries in the past nor has any history of co-morbidity. There was no significant family history. On medical examination, the patient was moderately built. The vitals were stable, including pulse: 80/minute; blood pressure: 112/86 mmHg; temperature: 98.40 Fahrenheit; and 96% SpO2 room air. There was no icterus, clubbing, cyanosis, pallor, or lymphadenopathy. No abnormality was detected on systemic and local examination. The Serum creatinine was 1.16 mg/dL, and other laboratory tests including Complete Blood Counts (CBC), Liver Function Tests (LFT), and blood glucose were within normal limits. X-ray KUB showed renal calculi in the region of the right kidney (Table/Fig 1).

Intravenous Pyelogram (IVP) showed right-sided renal calculus with the right ureter draining to the right-side (Table/Fig 2)a and one more ureter originating on the same side tracing towards the left-side (Table/Fig 2)b. The CT scan showed right bifid renal pelvis with a 17*11 mm calculus in the upper moiety and a 32*17 mm calculus in the lower moiety with moderate hydronephrosis. The left kidney was malrotated and fused with the lower pole of the right kidney, suggestive of crossed fused renal ectopia (Table/Fig 3)a,b. Two renal moieties were seen fused, and the left ureter traveling to the opposite side (Table/Fig 3)c. The diagnosis of the right renal calculi in a case of left crossed fused ectopic kidney was made. The decision was made to perform cystoscopy and retrograde pyelography and do open pyelolithotomy. Cystoscopy showed bilateral ureteric orifices at the normal position. Left cystoscopy and retrograde pyelography showed the ureter crossing over the right-side, whereas right cystoscopy and retrograde pyelography showed a bifid pelvis. Open pyelolithotomy was performed wherein a single pelvic incision was made through which calculi were removed, and the stent was placed. Postoperative X-ray KUB showed complete stone clearance (Table/Fig 4). After surgery, the patient was followed-up for suture removal after 12 days. Stent removal was done after 21 days, and the patient improved symptomatically.

Discussion

Crossed fused ectopic kidney is a rare congenital anomaly characterised by fusion and migration of the kidneys to the opposite side, resulting in both kidneys being located on the same side of the body (1). The prevalence of crossed fused ectopic kidney is estimated to be 1 in 1,000 live births (1), with an occurrence rate of 1 in 7,500 autopsies (2). Cross-Fused Renal Ectopia (CFRE) is usually asymptomatic, but symptoms like abdominal pain, dysuria, and haematuria can also be observed (3). This condition can lead to various complications, including Urinary Tract Infections (UTIs), kidney stone formation, infections, obstructions, and neoplasia (4). Calculus disease in crossed fused ectopic kidneys with a bifid renal pelvis is an even rarer finding. It can present significant challenges in terms of clinical management and treatment. Bilateral crossed ectopia is the rarest form to find. The ectopic solitary kidney is one of the most uncommon forms of ectopia, and the ectopic kidney may not fuse, even though fusion is eight times more common than non fusion (5). With a male-to-female frequency ratio of 3:1, crossed renal ectopia affects men more frequently than women. Right-to-left renal fusion is less common than left to right. It is a rare disease that may remain undiagnosed throughout life and is usually associated with vesicoureteral reflux, ureteropelvic junction obstruction, UTIs, renovascular hypertension, renal calculi, and malignancy (6). Renal fusion anomalies may involve abnormal rotation or vascular supply, creating challenges in open, minimally invasive surgeries, and endourological surgeries. CFRE patients typically present with UTI, stone formation, and generalised abdominal pain (7). Definitive diagnosis of CFRE is difficult. Congenital anomalies are identified through radiological investigations. Various radiological investigations like Ultrasonography (USG), IVP, and CT can be used. USG is the primary investigation of choice as it is relatively less costly and does not involve radiation. However, it has limitations, being observer-dependent and may not provide an accurate diagnosis. CT scan is a better investigation to examine renal anomalies as it can provide details about the number, position, vessels, ureteral dilatation, and malrotation (7),(8). Renal calculi in such cases can be managed by various methods such as open surgery, laparoscopic surgery, or lap-guided puncture for Percutaneous Nephrolithotomy (PCNL) and USG-guided PCNL. Asymptomatic renal anomalies without calculi or obstructions can be managed conservatively (8). These anomalies may present with various conditions such as pyelonephritis and calculi, which can be managed in various ways (9). (Table/Fig 5) discusses similar cases published in the literature (1),(2),(10),(11),(12),(13),(14),(15),(16),(17).

Conclusion

Crossed fused ectopic kidney is a rare congenital anomaly. Unless linked to other anomalies, they are typically detected inadvertently during the assessment of another ailment. Crossed fused renal ectopia is a rare anomaly with abnormal blood supply, making stone treatment challenging. With proper imaging and operative techniques, one could manage patients, making them stone-free and asymptomatic.

References

1.
Benabdallah W, Othmane MB, Bouassida K, Hmida W, Jaidane M. Crossed- fused renal ectopia with renal calculi and its management, A case report. Int J Surg Case Rep [Internet]. 2023;106:108218. Available from: http://dx.doi. org/10.1016/j.ijscr.2023.108218. [crossref][PubMed]
2.
Cao Y, Zhang Y, Kang W, Suo N, Cui Z, Luo Y, et al. Crossed-fused renal ectopia with renal calculi: Two case reports and a review of the literature. Medicine (Baltimore). 2019;98(48):e18165. Available from: http://dx.doi.org/10.1097/ md.0000000000018165. [crossref][PubMed]
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Ratola A, Almiro MM, Lacerda Vidal R, Neves N, Bicho A, Figueiredo S. Crossed renal ectopia without fusion: An uncommon cause of abdominal mass. Case Rep Nephrol. 2015;2015:679342. Available from: http://dx.doi. org/10.1155/2015/679342. [crossref][PubMed]
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Naseri M. Cross-fused renal ectopia associated with vesicoureteral reflux; a case report. J Renal Inj Prev. 2016;5(4):200-02. Available from: http://dx.doi. org/10.15171/jrip.2016.42. [crossref][PubMed]
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Debnath JC, Sarker KP, Uddin MN, Sarker SK, Rahman KM, Rahman AMA. Crossed fused ectopic kidney- A case report. TAJ J Teach Assoc. 2009;16(2):79- 81. Available from: http://dx.doi.org/10.3329/taj.v16i2.3889. [crossref]
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Nursal GN, Büyükdereli G. Unfused renal ectopia: A rare form of congenital renal anomaly. Ann Nucl Med. 2005;19(6):507-10. Available from: http://dx.doi. org/10.1007/bf02985579. [crossref][PubMed]
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Mudoni A, Caccetta F, Caroppo M, Musio F, Accogli A, Zacheo MD, et al. Crossed fused renal ectopia: Case report and review of the literature. J Ultrasound. 2017;20(4):333-37. Available from: http://dx.doi.org/10.1007/s40477-017-0245-6. [crossref][PubMed]
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Bhattar R, Maheshwari A, Tomar V, Yadav SS. Crossed fused ectopic kidney: A case report. J Clin Diagn Res. 2017;11(8):PD11-PD12. Available from: http:// dx.doi.org/10.7860/JCDR/2017/26944.10434. [crossref][PubMed]
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Reddy SJ, Shah MJ, Reddy BS, Chawla A, Singh A, Reddy BV. Crossed fused renal ectopia: A report of twelve cases at a tertiary health centre and literature review. Int J Res Med Sci. 2022;10(5):1161-68. Available from: http://dx.doi. org/10.18203/2320-6012.ijrms20221191. [crossref]
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Aminsharifi A, Niroomand R, Kroup M, Hosseini MM. Laparoscopic nephrolithotomy in a patient with crossed fused renal ectopia. Nat Rev Urol. 2009;6(12):675-79. Available from: http://dx.doi.org/10.1038/nrurol.2009.198. [crossref][PubMed]
11.
Resorlu M, Kabar M, Resorlu B, Doluoglu OG, Kilinc MF, Karakan T. Retrograde intrarenal surgery in cross-fused ectopic kidney. Urology. 2015;85(2):e5-6. Doi: 10.1016/j.urology.2014.10.013. Epub 2014 Dec 4. PMID: 25481231. [crossref][PubMed]
12.
Agrawal S, Chipde SS, Kalathia J, Agrawal R. Renal stone in crossed fused renal ectopia and its laparoscopic management: Case report and review of literature. Urol Ann. 2016;8(2):236-38. Doi: 10.4103/0974-7796.176871. PMID: 27141201; PMCID: PMC4839248. [crossref][PubMed]
13.
Amin QK, Arshad S, Anthony N, Yousafzai ZA, Arshad S. Case report on crossed fused renal ectopia with a large calculus and its management. Cureus. 2021;13(6):e15512. Doi: 10.7759/cureus.15512. PMID: 34268042; PMCID: PMC8264620. [crossref]
14.
Kumawat G, Singla M, Mehta N, Gupta P, Yadav SS. Crossed complete fused left to right renal ectopia with solitary left ureter: A rare ‘case report’. Afr J Urol. 2020;26:76. Available from: https://doi.org/10.1186/s12301-020-00084-z. [crossref]
15.
Huang L, Lin Y, Tang Z, Lie D, Wang Z, Chen H, et al. Management of upper urinary tract calculi in crossed fused renal ectopic anomaly. Exp Ther Med. 2018;15(1):371-76. [crossref]
16.
Akdogan L, Oguz AK, Ergun T, Ergun I. The rarest of the rare: Crossed fused renal ectopia of the superior ectopia type. Case Rep Nephrol. 2015;2015:742419. [crossref][PubMed]
17.
Kaur N, Saha S, Mriglani R, Saini P, Gupta A. Crossed fused renal ectopia with a single ureter: A rare anomaly. Saudi J Kidney Dis Transpl. 2013;24(4):773-76.[crossref][PubMed]

DOI and Others

DOI: 10.7860/JCDR/2024/68368.19266

Date of Submission: Oct 31, 2023
Date of Peer Review: Dec 22, 2023
Date of Acceptance: Feb 07, 2024
Date of Publishing: Apr 01, 2024

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Nov 02, 2023
• Manual Googling: Jan 17, 2024
• iThenticate Software: Feb 05, 2024 (11%)

ETYMOLOGY: Author Origin

EMENDATIONS: 6

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