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A Narrative Review Unveiling Novel Molecular Targets in Advancing Antidiabetic Medications: An Emerging Perspective
Correspondence Address :
Dr. Balamurali Venkatesan,
Tutor, Department of Microbiology, Sri Lalithambigai Medical College and Hospital, Faculty of Medicine, Dr. MGR Educational and Research Institute, Service Road, Maduravoyal, Adayalampattu, Chennai-600095, Tamil Nadu, India.
E-mail: balajai96@gmail.com
Diabetes Mellitus (DM) is a persistent metabolic disorder characterised by elevated glucose concentration in blood. Approximately, 422 million individuals globally suffer from diabetes, with the majority residing among middle-class and lower-class countries as per the reports of World Health Organisation (WHO) 2023. Strict blood sugar control in conjunction with high-dose insulin therapy might potentially prevent or delay the progression of microvascular issues, lower overall mortality, and lessen the chance of macrovascular problems. These conclusions were supported by the Diabetes Control and Complications Trial and the large longitudinal investigation known as the epidemiology of diabetes and its complications. Numerous drugs and receptors involved in glucose metabolism are currently being used to treat diabetes, including α-Glucosidase inhibitors, dopamine D-2 agonists, biguanides, glinides, amylin analogues, Peroxisome Proliferator-activated Receptors (PPARs), Glucagon-like Peptide-1 (GLP-1), and biguanides. Due to the associated side effects and the financial difficulties in obtaining traditional antidiabetic regimens, the current review has placed a higher priority on investigating novel molecular targets for the development of antidiabetic medications intended to manage the progression of the illness. This emphasises how important it is to find new molecular targets associated with the illness’s onset instead of only treating its symptoms or outward signs.
Diabetes mellitus, Glucose metabolism, Insulin therapy
DOI: 10.7860/JCDR/2024/69066.19454
Date of Submission: Dec 12, 2023
Date of Peer Review: Feb 14, 2024
Date of Acceptance: Mar 14, 2024
Date of Publishing: May 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? No
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 13, 2023
• Manual Googling: Feb 27, 2024
• iThenticate Software: Mar 11, 2024 (8%)
ETYMOLOGY: Author Origin
EMENDATIONS: 7
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