Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Mohan Z Mani

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Professor & Head,
Department of Dermatolgy,
Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018




Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



Dr Kalyani R
Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018




Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
As an experienced dentist and an academician, I proudly recommend this journal to the dental fraternity as a good quality open access platform for rapid communication of their cutting-edge research progress and discovery.
I wish JCDR a great success and I hope that journal will soar higher with the passing time."



Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."



Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".



Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Reviews
Year : 2024 | Month : June | Volume : 18 | Issue : 6 | Page : LE01 - LE05 Full Version

Harnessing the Power of Ayurveda for Diabetes Management: A Narrative Review


Published: June 1, 2024 | DOI: https://doi.org/10.7860/JCDR/2024/70617.19479
Naveen Singh, Devyani Dasar

1. Postgraduate Scholar, Department of Shalya Tantra, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education, Wardha, Maharashtra, India. 2. Associate Professor, Department of Shalya Tantra, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education, Wardha, Maharashtra, India.

Correspondence Address :
Naveen Singh,
Room No. 13, Department of Shalya Tantra, MGACH and RC, Salod, Wardha-442001, Maharashtra, India.
E-mail: nishu251114@gmail.com

Abstract

Ayurveda, an age-old medical tradition originating from India, provides a comprehensive method for addressing diabetes mellitus. Diabetes, marked by increased blood sugar levels, is a persistent metabolic condition posing a widespread health challenge worldwide. Ayurveda, drawing upon principles of balance and individualised treatment, addresses diabetes through a multifaceted lens. In Ayurveda, diabetes is classified under the term “Madhumeha,” where an imbalance in the body’s doshas (Vata, Pitta, and Kapha) disrupts the normal functioning of the pancreas and impairs insulin production. The approach to diabetes management in Ayurveda involves a personalised assessment of an individual’s constitution (Prakriti) and the identification of imbalances (Vikriti). Lifestyle modifications, dietary changes, herbal supplements, and therapeutic practices like yoga and meditation are integral components of Ayurvedic interventions. Plants like bitter melon (Momordica charantia), fenugreek (Trigonella foenum-graecum), and turmeric (Curcuma longa) are essential components in Ayurvedic remedies designed to address diabetes. These herbs are believed to have hypoglycaemic properties, helping regulate blood sugar levels. Additionally, practices like Panchakarma, a detoxification process, are employed to eliminate toxins and restore balance in the body. Ayurveda emphasises the importance of maintaining a sattvic (balanced) lifestyle, incorporating mindful eating habits, regular exercise, and stress management. While Ayurvedic interventions for diabetes have shown promise, it is essential to consult qualified practitioners to ensure personalised and safe approaches. As the global burden of diabetes continues to rise, exploring complementary strategies like Ayurveda provides a holistic perspective on diabetes management that aligns with the principles of balance and wellbeing.

Keywords

Diabetes mellitus type 1, Diet, Glucose intolerance, Prevention and control

Diabetes mellitus is a widespread ailment affecting both developed and developing nations. This chronic condition pertains to the metabolism of carbohydrates, characterised by elevated blood sugar levels (hyperglycaemia) and the detection of sugar in the urine (glycosuria). The root cause of diabetes lies in the insufficient production or utilisation of insulin, a hormone crucial for regulating blood sugar levels. This metabolic disorder poses a significant health challenge globally, as it disrupts the body’s ability to effectively manage glucose, leading to a range of complications. The imbalance in insulin dynamics contributes to the persistent elevation of blood sugar, underscoring the intricate interplay between physiological factors involved in maintaining glucose homeostasis. The prevalence of diabetes underscores the pressing need for effective management strategies and emphasises the importance of ongoing research to better understand the intricacies of this complex metabolic condition (1).

In the realm of Ayurveda, diabetes finds its counterpart in a condition known as ‘Madhumeha.’ Ayurvedic perspectives highlight striking similarities in the causative factors, clinical manifestations, and complications between Diabetes Mellitus and Madhumeha. Both conditions share commonalities in their origin and expression, underscoring the parallel observations made by Ayurveda in understanding these metabolic disorders. The recognition of comparable features in terms of causation, clinical presentation, and potential complications reinforces the Ayurvedic viewpoint that perceives these conditions through a lens of shared characteristics and interconnected physiological disruptions (2).

The root causes of diabetes mellitus remain uncertain, and the condition is thought to be influenced by various factors. Genetic predisposition, viral infections, and lifestyle choices such as excessive eating, particularly when coupled with obesity and physical inactivity, are linked to the onset of diabetes mellitus. Ayurveda aligns with these perspectives, stating that diabetes mellitus has inherited effects and bad behaviours as aetiological causes. In Ayurvedic terms, the transmission of the disease is attributed to flawed paternal and maternal germinal seeds. Unhealthy activities contributing to diabetes encompass prolonged periods of excessive sleep, the use of soft cushions, prolonged consumption of curd, milk, jaggery, sugar, and fresh grain-based foods, as well as the intake of flesh from domestic and aquatic animals. Additionally, Ayurveda highlights the impact of using fresh rainwater and the psychological stress generated through unfulfilled sexual urges as factors contributing to the development of diabetes. These parallel insights from both conventional and Ayurvedic perspectives shed light on the multifaceted nature of diabetes mellitus, acknowledging a combination of genetic, lifestyle, and environmental influences in its aetiology (3),(4),(5).

As of 2014, an estimated 422 million individuals globally grapple with diabetes, and approximately 90% of these cases belong to the type-2 diabetes category. This prevalence translates to 8.3% of the adult population, affecting both women and men equally. Within the timeframe spanning 2012 to 2014, diabetes is believed to have contributed to an annual death toll ranging from 1.5 to 4.9 million (6). The contributing factors of type-2 diabetes closely resemble the disease entities Prameha/Madhumeha in Ayurveda. Sahaja Prameha (Hereditary) and Apathyanimittaja Prameha (type 2 diabetes) are the two primary types of Prameha that are described in Ayurvedic scriptures. Apathyanimittaja Prameha bears significant similarities to contemporary notions of Type-2 Diabetes Mellitus. In light of these parallels, Ayurveda introduces the concept of Sthula Pramehi, drawing a clear correspondence to the modern understanding of obesity and its pivotal role in the development of type-two Diabetes mellitus. This correlation between Ayurvedic classifications and contemporary medical concepts underscores the timelessness and cross-cultural relevance of understanding diabetes and its associated factors (7).

In the realm of Ayurveda, the principles of Chikitsa Siddhanta, or treatment methodologies, are designed with the overarching goal of disrupting the Samprapti, or the pathophysiology, of a disease. The emphasis lies in eradicating the ailment at its root rather than merely alleviating the symptomatic manifestations. Ayurvedic treatment strategies prioritise a comprehensive approach that addresses the fundamental imbalances and root causes of a condition, aiming for a more profound and sustained resolution rather than superficial relief from symptoms. This approach aligns with the core philosophy of Ayurveda, which seeks to restore holistic balance and wellbeing by understanding and rectifying the underlying disturbances that can aid in the onset and development of illnesses. Indeed, within the framework of Ayurveda, the concept of Prameha encompasses two primary categories: Sahaja Prameha and Apathyanimittaja Prameha (8).

1. Sahaja Prameha: Sahaja Prameha refers to diabetes that has a congenital or hereditary origin. In this context, ‘Sahaja’ translates to ‘innate’ or ‘inborn.’ This category underscores the genetic predisposition or hereditary factors contributing to the development of diabetes (9).

2. Apathyanimittaja Prameha: Apathyanimittaja Prameha is characterised by diabetes that arises due to inappropriate lifestyle choices and behaviours. ‘Apathyanimittaja’ indicates causation due to unhealthy practices. Factors such as dietary indiscretions, sedentary habits, and other lifestyle-related choices contribute to the onset of diabetes in this category. Understanding these classifications allows Ayurvedic practitioners to tailor treatments and interventions based on the specific nature and causative factors of Prameha, providing a more personalised and effective approach to managing diabetes (8).

The two key contributing factors to the Prameha aetiology are a less active lifestyle and Ahitakara Aahara, or unwholesome food. Ayurveda offers more ability to treat metabolic illnesses by addressing lifestyle and nutrition issues, which are mainly responsible for Prameha, by adhering to certain dietary guidelines and the practices of Dinacharya and Ritucharya. Ayurveda has the ability to prevent Sahaja vikara in other ways as well, such as Atulyagotra marriage, which avoids marriage within the same family (9).

Prameha is a term used in Ayurveda to describe a group of urinary disorders, primarily focusing on conditions related to diabetes mellitus. It encompasses a range of metabolic disorders characterised by abnormal urine composition, often associated with elevated blood sugar levels. Ayurveda recognises Prameha as a complex condition with various subtypes, each influenced by different causative factors (9).

Elevated levels of glucose (blood sugar) in the body are the hallmark of diabetes, also known as diabetes mellitus, a chronic metabolic disease. The underlying reason is either inadequate production of insulin, inadequate usage of insulin, or a mix of the two. The pancreas secretes the hormone insulin, which helps cells absorb glucose and is essential for regulating blood sugar levels (10).

Diabetes manifests in various forms, but the primary distinctions lie within two major categories:

1. Type 1 Diabetes:

Cause: Occurs when the immune system unintentionally targets and destroys the pancreatic beta cells responsible for producing insulin.

Onset: Often diagnosed in childhood or adolescence.

2. Type 2 Diabetes:

Cause: Emerges when the body exhibits resistance to insulin, or when there is insufficient insulin production by the pancreas.

Onset: Usually manifests in adulthood, but there is a growing trend of diagnosis among children and adolescents (11).

Diabetes often presents itself through a range of common symptoms. Individuals with diabetes may experience frequent urination, driven by the body’s attempt to eliminate excess sugar. This excessive urination can lead to increased thirst as the body strives to maintain fluid balance. The breakdown of muscle and fat tissues for energy in the absence of enough insulin may be the cause of unexplained weight loss. An inefficient utilisation of glucose by the body as a source of energy leads to increased hunger. Fatigue is a prevalent symptom, stemming from disrupted energy metabolism. Blurred vision can occur due to changes in fluid levels in the eye’s lens, and slow wound healing is a consequence of impaired circulation and immune function associated with diabetes. Recognising these symptoms is crucial for early detection and effective management of diabetes (12).

Gastrointestinal-Mediated Glucose Disposal (GIGD) is Emerging as a Comprehensive Concept in Understanding how the Gut Influences Overall Glucose Metabolism

The gut plays a pivotal role in maintaining the balance of glucose throughout the entire body. Various factors influence how the gut manages glucose and the combined processes in post-meal glucose metabolism within the gut is now termed GIGD. This term is mainly used to gauge how effectively the body clears glucose through the incretin effect, which is currently recognised as the most impactful gut-related factor affecting glucose metabolism (13).

Incretin Effect and its Role in Whole Body Glucose Homeostasis

When we eat, certain cells in the lining of the gut, known as Enteroendocrine Cells (EECs), release various peptide hormones. These hormones influence the release of insulin and signals related to feeling full after eating. Among these hormones, incretins, discovered in the 1980s, have drawn significant attention in the management of diabetes. In addition to boosting insulin production, incretin hormones also affect the movement of the digestive system and play a role in the communication between the gastrointestinal tract and other organs. Their multifaceted functions make them important players in regulating various aspects of the body’s response to food (13).

Ayurvedic experts customise diet, physical activity, and daily habits, along with recommending specific treatments, medications, and herbal remedies, to harmonise the doshas and enhance overall wellbeing in individuals. The main remedies in Ayurveda predominantly come from plants, although substances sourced from metals, minerals, marine life, and animals may also be incorporated (14). At present, the Indian government oversees the entire process of formulating policies, fostering development, and executing Ayurvedic programs (15). In the late 1970s, the World Health Organisation (WHO) started recognising the advantages of traditional medicines, contributing to the increased worldwide recognition of Ayurveda (16). The available evidence supporting the efficacy of Ayurveda in treating diabetes mellitus is restricted. However, there are numerous accounts of certain herbal combinations, including Ayurvedic medicines, demonstrating glucose-lowering effects without any reported adverse events (14).

Pathophysiology Of Diabetes Mellitus

Oxidative stress, caused by an imbalance between the effectiveness of enzymatic or nonenzymatic antioxidants and the generation of Reactive Oxygen Species (ROS), is the main factor in the development of diabetes. Both nonradical species like hydrogen peroxide and free radicals including superoxide, hydroxyl, peroxyl, and hydroperoxyl are considered ROS. The damaging effects of ROS are offset by antioxidants such as glutathione reductase, superoxide dismutase, carotenoids, trace minerals, as well as vitamins A, C, and E. Oxidation of low-density lipoprotein cholesterol occurs when ROS are present, causing it to be absorbed by scavenger cell receptors to form foam cells and plaques associated with arterial sclerosis. These ROS have the ability to trigger several harmful processes essential for the advancement of diabetes, including the sorbitol aldose reductase route, electron transport chain, protein kinase C activation, and glucosamine pathway. Atherosclerosis, the creation of Advanced Glycation End products (AGEs) by lipid peroxidation, amylin buildup, and the impairment of pancreatic β-cell function can all result from the activation of these pathways. Certainly! Nrf2, a specific DNA-binding factor, and its counterpart Keap1 play crucial roles in safeguarding cells against oxidative stress (17).

Charaka extensively details the underlying progression of Prameha in the Nidana sthana (Ca. Ni. 4/8). Despite Prameha being categorised as a Tridosika disease, its onset is initially marked by the disturbance of Kapha Dosa. Prolonged and excessive consumption of Kapha-aggravating diet and lifestyle practices result in the imbalance of Kapha. The vitiated Kapha, referred to as Bahudrava Kapha, shares fundamental similarities with Meda (fat tissue). These elements interact and circulate alongside loose Medas throughout the body. As the condition advances, the vitiated Kapha engages with Mamsa (muscle tissue) and Kleda (mucus), leading to the formation of Prameha Pidika with Mamsa and the conversion of Kleda into Mutra (urine). The amalgamation of vitiated Meda and Kleda obstructs the openings of the Mutravaha Srotas (urinary channels). This obstruction persists for a considerable duration, ultimately resulting in the manifestation of Kaphaja type of Prameha (18).

Evolution of Diabetes Epidemiology: Shifting Patterns and Trends

Diabetes Mellitus (DM) was first recognised by the ancient Indian physicians Charaka and Sushruta (600–400 BC). They called it Madhumeha, which was characterised by excessively sweet urine. With astuteness, they observed how symptoms varied among patients, noting that some were skinny with severe polyuria, thirst, and dehydration, while others were stout, ate a lot, and did not exercise (19). These differences eventually led to the classification of diabetes as insulin-dependent (type 1) and noninsulin-dependent (type 2), respectively. The development of uniform diagnostic and categorisation standards has greatly improved the ability to compare diabetes data globally (20). The standardisation of diagnostic and categorisation criteria has not only made it easier to estimate the prevalence of diabetes worldwide but has also been essential for future forecasts (21),(22),(23).

Long-term Effects of Diabetes

The financial impact of diabetes arises from the ongoing management of individuals with the condition, and the costs significantly increase when vascular complications arise. Unfortunately, there is a shortage of population-based information on the occurrence of both small-scale (microvascular) and large-scale (macrovascular) complications in various regions of the developing world. It has been observed that about 30% of individuals with type 2 diabetes experience retinopathy, with its prevalence being particularly notable in Asian and Pacific Island nations (24). Research conducted in southern India found that 34.1% of individuals surveyed had diabetic retinopathy (25). India has recorded elevated occurrences of Cardiovascular Disease (CVD) [26,27]. Similarly, high rates of CVD have been observed not only in other Asian nations but also among Indian migrant populations (28). In Chennai, data reveals the occurrence of complications in type 2 diabetes, with the following prevalence rates: retinopathy at 23.7%, nephropathy at 5.5%, peripheral neuropathy at 27.5%, CVD at 11.4%, peripheral vascular disease at 4.0%, and stroke at 0.9%. Additionally, there is a high prevalence of hypertension, standing at 38.0%. The occurrence of coronary heart disease among Indians might be equally elevated, comparable to the rates observed in immigrant Indian populations (29). It was observed that approximately 84% of patients admitted with acute coronary syndrome exhibited abnormal glucose tolerance. In comparison to the Caucasian population, Asian Indians have a lower prevalence of peripheral vascular disease (9.3%). Despite the lower prevalence of peripheral vascular disease, neuropathy is highly prevalent and serves as a contributing risk factor for recurrent foot infections (30),(31).

Prevention of Diabetes

India needs to implement proactive measures to ease the impact of diabetes, as the current financial allocations for diabetes care do not adequately address the significant healthcare challenge it poses. The onset of diabetes arises from an intricate interaction of genetic and environmental elements. While the genetic aspect remains immutable, numerous environmental factors can be altered. Elements like obesity, dietary preferences, and physical activity belong to the group of risk factors that can be changed or influenced. The way diet and exercise interact plays a crucial role in shaping the distribution of body fat and significantly impacts insulin sensitivity. Adopting traditional lifestyles characterised by a diet low in saturated fat and rich in complex carbohydrates, coupled with increased physical activity, may serve as protective measures against the emergence of cardiovascular risk factors and diabetes. This remains valid even when there is a potential genetic inclination (32).

According to Ayurveda management of Diabetes

Ancient Indian physicians were familiar with diabetes mellitus (Madhumeha), and Ayurvedic texts provide a detailed account of its clinical features and management. Ayurvedic practitioners employ a comprehensive approach to address diabetes, incorporating diet adjustments, Panchkarma for system cleansing, herbal formulations, yoga, and breathing exercises (33). Various plants, such as shilajit, turmeric, neem, Coccinia indica, amla, triphala, bitter gourd, rose apples, bael leaves, cinnamon, gymnema, fenugreek, bay leaves, and aloe vera, are employed for managing diabetes (34).

Plants Used for Diabetes

Abrus precatorius (Fabaceae)- Gunja (35)

The leaves of A. precatorius are crushed, and the juice obtained is separated. After allowing this juice to settle for four to five hours, the sediment is collected. A dose of 10 grams of this sediment is mixed with bee’s honey and given to individuals with diabetes.

Acacia arabica (Fabaceae)- Babbula (36)

A decoction is made using 60 grams of dried stem bark from A. arabica, and a 120 mL portion of this preparation is consumed twice daily.

Acacia chundra (Fabaceae) – Khadira (37)

A decoction is created using 60 grams of dried stem bark obtained from A. chundra, and a 120 mL portion of this concoction is administered twice daily.

Achyranthes aspera (Amaranthaceae) – Apamarga (37)

A decoction is crafted using 60 grams of dried entire plant material from A. aspera, and a 120 mL dosage of this preparation is administered twice a day.

Alternanthera sessilis (Amaranthaceae) – Matsyakshi (36)

The A. sessilis plant, weighing 50 grams, is chopped into small pieces and crushed thoroughly. Following this, 100 mL of water is added to extract the juice, which is then ingested. The upper part of the plant is finely chopped and mixed with scraped coconut, salt, and turmeric powder. The blend is heated in a pan until cooked and is subsequently consumed with rice.

Anethum graveolens (Apiaceae) – Satapushpa (38)

The dried seeds of A. graveolans are grounded into a powder, and a 10-gram portion of this powder is administered twice daily.

Chikitsa Sutra (Principles of Treatment) (39)

In cases of Pramehas, Kapha experiences imbalances across all types, but in Madhumeha, there is a notable tendency for Vata to be exacerbated as well. Consequently, treatment strategies aim to address both Kapha and Vata concurrently. According to Charaka, individuals with obesity and a robust physique are advised to undergo Samsodhana treatment, which focuses on purification. Conversely, those with a lean and weak body structure are recommended to opt for Brihmana therapy, emphasising nourishment and strengthening. Sushruta suggests that individuals with emaciated or underweight Pramehi conditions should undergo treatment involving nourishing measures, including a processed diet and specific drinks. In contrast, for those who are obese, the recommended approach involves measures aimed at reducing excess, such as exercise (Vyayama) and purification (shodhana).

Ausadhi (medicines): It is evident that Kapha Dosha plays a significant role in Prameha, and the corrupted fat tissue (Dusya Meda) shares a similar nature. In Ayurveda, the recommended treatment for Prameha involves the use of drugs with Tikta (bitter), Katu (pungent), and Kashaya (astringent) tastes. Susruta specifically highlights the use of a decoction containing drugs from the Salasaradi Gana category along with Shilajatu for the effective treatment of “Prameha/Madhumeha(40).

Ahara (diet): The primary emphasis in disease management, as strongly advocated in various medical texts, is “Nidana Parivarjana,” which involves avoiding the causative factors of the ailment. For Prameha, it is advised to adopt a diet that does not contribute to weight gain and opposes the factors leading to the condition. Considering that diabetes is closely associated with a modified lifestyle and impaired digestive fire (Agni), special attention should be given to dietary choices and purificatory measures. Charaka recommends Yava (barley) and similar grains as the principal diet for individuals with Prameha. He proposes an interesting method where Yava is initially fed to animals, and the remaining parts collected from the dung of these animals are then consumed by those dealing with Prameha. This approach is aimed at ensuring the suitability of the diet for managing the condition (40).

Vihara (exercise and yoga): As previously noted, the absence of physical activity and excessive daytime and night-time sleep significantly contribute to the onset and progression of Prameha. In the advanced stages of Prameha, Sushruta recommends incorporating regular physical exercise into the lifestyle of those dealing with the condition. This includes engaging in activities such as wrestling, participating in sports, horseback or elephant riding, extended walks, pedestrian journeys, archery practice, and javelin casting. These activities are advised as beneficial measures for individuals in the advanced stages of Prameha (40).

Discussion

Global Diabetes Challenge

Diabetes mellitus is a prevalent and chronic metabolic disorder that affects populations globally. It is characterised by elevated blood sugar levels and glycosuria. Insufficient production or utilisation of insulin, a hormone crucial for regulating blood sugar levels, is at the core of this metabolic dysfunction. Diabetes poses a significant health challenge, disrupting the body’s ability to manage glucose effectively and leading to various complications. The complex interplay of physiological factors underscores the intricate nature of maintaining glucose homeostasis (41).

Madhumeha: Ayurvedic Perspective

In the Ayurvedic context, diabetes finds its counterpart in ‘Madhumeha,’ where parallels in causative factors, clinical manifestations, and complications are recognised between Diabetes Mellitus and Madhumeha. Both systems of medicine acknowledge the shared characteristics and interconnected disruptions in physiological processes associated with these metabolic disorders.

The root causes of diabetes involve genetic predisposition, viral infections, and lifestyle choices, including excessive eating, obesity, and physical inactivity. Ayurveda aligns with these perspectives, attributing diabetes to hereditary influences and unhealthy behaviours. The transmission of the disease is linked to flawed paternal and maternal germinal seeds, with lifestyle factors such as prolonged sleep, the use of soft cushions, and specific dietary choices contributing to its onset (42).

The global prevalence of diabetes emphasises the urgency for effective management strategies and ongoing research to comprehend the complexities of this condition. Ayurveda introduces the concept of ‘Prameha,’ encompassing Sahaja Prameha (congenital or hereditary) and Apathyanimittaja Prameha (due to unhealthy lifestyle choices). The latter closely aligns with the modern understanding of Type-2 Diabetes mellitus (40).

The principles of Chikitsasidhhanta in Ayurveda prioritise disrupting the pathophysiology of a disease at its root rather than merely alleviating symptoms. Two main categories of Prameha, Sahaja Prameha, and Apathyanimittaja Prameha, guide Ayurvedic practitioners in tailoring treatments based on specific causative factors (43).

Ayurvedic Perspectives on Public Health and Disease Prevention

Epidemiological data underscores the changing trends in diabetes, with approximately 387 million individuals affected globally, primarily by Type-2 Diabetes. Chronic complications, both microvascular and macrovascular, contribute to the financial burden of diabetes care, necessitating preventive measures (44).

Prevention strategies in Ayurveda focus on modifying modifiable risk factors, such as obesity, dietary choices, and physical activity. The interplay between diet and exercise plays a crucial role in shaping body fat distribution, impacting insulin sensitivity.

Ayurvedic management of diabetes involves a triangular approach– Ahara (Diet), Vihara (Exercise and Yoga), and Ausadhi (Medicines). Medicines include herbal formulations like Shilajatu, turmeric, neem, and specific Ayurvedic preparations. Dietary recommendations in Ayurveda suggest a diet that opposes the factors leading to diabetes, incorporating grains like Yava. Exercise and physical activities are emphasised, aligning with the Ayurvedic prescription for those dealing with diabetes (45).

In summary, the integration of Ayurvedic principles into the understanding and management of diabetes provides a holistic approach, addressing the multifaceted nature of this metabolic disorder. The timeless wisdom of Ayurveda offers valuable insights that complement contemporary medical perspectives, paving the way for a more comprehensive and personalised approach to diabetes care.

Conclusion

In conclusion, diabetes mellitus presents a significant global health challenge characterised by elevated blood sugar levels and disruptions in insulin regulation, showcasing the intricate balance required for glucose homeostasis. Ayurveda’s recognition of ‘Madhumeha’ as diabetes counterpart underscores shared aetiological and clinical features, bridging traditional and modern medical perspectives. Root causes of diabetes, including genetic predisposition and lifestyle factors, resonate with Ayurvedic principles, emphasising the need for comprehensive management strategies and ongoing research efforts. Ayurveda’s classification of ‘Prameha’ parallels modern Type-2 Diabetes classification, highlighting the relevance of Ayurvedic insights in contemporary medicine. Ayurvedic management focuses on addressing root causes through personalised approaches, integrating diet, exercise, and herbal formulations to foster sustained resolution. Emphasising preventive measures, Ayurveda advocates for lifestyle modifications, aligning with the interplay between diet, exercise, and insulin sensitivity. Overall, the integration of Ayurvedic principles enriches diabetes care, offering a holistic and personalised approach to improving well-being and the quality of life for affected individuals.

Disclaimer: This paper is being published to highlight the ancient understanding of human physiology. However, readers are cautioned that the medicine has advanced with better methods of treatment and more evolved understanding.

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DOI and Others

DOI: 10.7860/JCDR/2024/70617.19479

Date of Submission: Mar 09, 2024
Date of Peer Review: Apr 11, 2024
Date of Acceptance: May 02, 2024
Date of Publishing: Jun 01, 2024

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA

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