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Cariprazine Augmentation in Inadequate Clozapine Response: A Case Series
Correspondence Address :
Dr. Jibi Achamma Jacob,
Associate Professor, Department of Psychiatry, Christian Medical College, Vellore-632002, Tamil Nadu, India.
E-mail: jibiachamma@gmail.com
Managing patients with treatment-resistant schizophrenia who do not respond adequately to Clozapine poses a challenge. Cariprazine, with its unique mechanism of action, may be an option for such patients. The additional benefits of using Cariprazine as an augmentation strategy include once-daily dosing, ease of titration, and a favourable side-effect profile. The report outlines the authors’ experience of six patients with treatment-resistant schizophrenia who did not respond to Clozapine. The addition of Cariprazine was tolerated by all the patients. The majority showed improvement with symptom reduction, and in some cases, the dose of Clozapine could be reduced, thereby decreasing the side-effects of Clozapine.
Anti-psychotic agents, Clozapine related side-effects, Ultra-resistant schizophrenia Anti-psychotic agents, Clozapine related side-effects, Ultra-resistant schizophrenia
DOI: 10.7860/JCDR/2024/69088.19525
Date of Submission: Dec 14, 2023
Date of Peer Review: Mar 02, 2024
Date of Acceptance: Apr 25, 2024
Date of Publishing: Jun 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Dec 15, 2023
• Manual Googling: Mar 14, 2024
• iThenticate Software: Apr 24, 2024 (12%)
ETYMOLOGY: Author Origin
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