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Case of Malignancy Arising from Giant Cell Tumour of Soft-tissue Involving Thyroid Mimicking Thyroid Carcinoma: A Potential Pitfall
Correspondence Address :
Rachel Abraham,
‘Muttattu’, House No. 411, 4th Lane, Mar Ivanios Nagar, Kesavadasapuram, Pattom PO, Thiruvananthapuram-695004, Kerala, India.
E-mail: dr.rachelabraham@gmail.com
Giant Cell Tumour of soft-tissue (GCT-ST) is a rare neoplasm which is morphologically similar and genetically unrelated to GCT bone and included under intermediate rarely metastasising category. They are reported predominantly in superficial soft-tissue of the upper and lower extremities and less frequently in head and neck. The authors present a case of malignancy arising from GCT-ST involving thyroid gland mimicking primary thyroid malignancy. An 80-year-old female presented in the Outpatient Department (OPD) with a neck swelling of six months duration and sudden increase in size and hoarseness of voice for two weeks. An upfront surgery was planned with a clinical suspicion of primary thyroid neoplasm. Intraoperatively, the thyroid gland was replaced by multiple nodules, which were seen infiltrating adjacent structures. Due to the invasive nature, only a subtotal thyroid resection was done. The histopathology showed predominantly neoplasm composed of mononuclear cells and sheets of osteoclast like giant cells with foci showing features of malignancy. Histomorphology along with Immunohistochemistry (IHC) confirmed a diagnosis of GCT-ST involving the thyroid gland. Due to the rapidly progressive nature of the disease, the patient succumbed within two months.
Anaplastic thyroid carcinoma, Fine needle aspiration cytology, Immunohistochemistry, Metastasis, Spindle cells
DOI: 10.7860/JCDR/2024/70257.19558
Date of Submission: Feb 23, 2024
Date of Peer Review: Apr 01, 2024
Date of Acceptance: Apr 16, 2024
Date of Publishing: Jun 01, 2024
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? No
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
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