Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
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On May 11,2011




Dr. Shankar P.R.

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On Jan 2020

Important Notice

Case report
Year : 2008 | Month : April | Volume : 2 | Issue : 2 | Page : 764 - 767

Paroxysmal nocturnal haemoglobinuria with Budd Chiari syndrome and Myelofibrosis

ABBAS MT*, KHAN FY**, MATAR I***, BAIDAA A****

*Senior specialist, department of medicine/Hamad General Hospital/ Doha-Qatar.**Senior specialist, Department of Medicine/ Hamad General Hospital/ Doha-Qatar.***Consultant, Department of Medicine/ Hamad General Hospital/ Doha-Qatar ****Specialist, Alwakrah health centre.

Correspondence Address :
Dr. Mushtak Talib Abbas (MD) (MRCP), Senior Specialist/ Department of Medicine Hamad general Hospital/Doha-Qatar.E Mail: amushtak@hotmail.com, PO Box 3050.Tel: 009745220486, Fax 009744392273

Abstract

We report a case of paroxysmal nocturnal haemoglobinuria (PNH) in a 38-year-old Indian female, who was admitted to our hospital with abdominal distension of 2-weeks duration, with leg oedema and jaundice. Her medical history was remarkable for deep vein thrombosis 15 years back, and stroke, nine years before admission. On clinical examination, spleen and liver were palpable, along with evidence of shifting dullness on abdominal percussion. Bone marrow examination showed hypoplastic bone marrow with agnogenic myeloid metaplasia, with myelofibrosis. Acidified serum lysis (Ham test) and sucrose lysis tests were strongly positive. The diagnosis of PNH was confirmed by flow cytometry. The patient could not be followed further, as she left for her country.

Keywords

Budd-Chiari Syndrome; Myelofibrosis; Paroxysmal nocturnal haemoglobinuria

Introduction
PNH is an acquired haemopoietic stem cell disorder, characterized clinically by chronic haemolytic anaemia, with acute episodes, thrombosis, and bone marrow failure. It is a rare condition, which usually occurs in younger people. Immunophenotyping and flow cytometry play a key role in confirming the diagnosis of PNH. Treatment is mainly supportive. Since the disease is uncommon, delay in diagnosis often lead to deleterious effects on patient management and prognosis. We present this case to draw attention to this rare cause of Budd chiarii syndrome and Myelofibrosis, which should be considered in any patient of any age, who has signs of hepatic vein thrombosis.

Case Report

A 38-year-old Indian female visitor to Doha was admitted to our hospital with abdominal distension of 2-weeks duration, with leg oedema and jaundice. Her condition started three years ago with pain and abdomen distension that progressed gradually; and was diagnosed as liver cirrhosis. Past medical history was remarkable for deep vein thrombosis 15 years back, and stroke, nine years before admission. On examination, she had jaundice, clubbing of fingers, spider nevi, and leg oedema. Abdomen examination showed hepatomegaly with liver span of 15 cm, and splenomegaly, 6 cm below the costal margin, with positive shifting dullness. The results of investigations are presented in (Table/Fig 1).Peripheral smear picture is presented in (Table/Fig 2).

Ultrasound abdomen showed cirrhotic liver with echogenic thrombus in the intrahepatic segment of IVC, with ascitis (Table/Fig 3). Upper endoscope showed oesophageal Varices grade 2. In view of the above findings, hypercoagulable state was highly suspected, and thus, the following tests were requested: Anti thrombin function, protein C and S factor. V Leiden and homocysteine were normal. Anticardiolipine IGg and IgM levels were within normal limits. Bone marrow examination showed hypoplastic bone marrow with Agnogenic Myeloid Metaplasia, with Myelofibrosis (Table/Fig 4). Acidified serum lysis (Ham test) and sucrose lysis test were strongly. To confirm the diagnosis, flow cytometry was performed, which showed a deficiency of CD59 and CD55 on red cells. Thus, the patient was diagnosed with PNH complicated with Budd Chiarii syndrome (BCS) and myelofibrosis. The patient was treated symptomatically by blood transfusion, Iron, folic acid, and diuretic. The patient was discharged against medical advice, and she left the country forever.

Discussion

PNH is characterized by intravascular haemolysis, venous thrombosis, and an association with aplastic anaemia (1).PNH arises through a somatic mutation of the phosphatidylinositolglycan complementation class A (PIGA) gene in a haematopoietic stem cell, and the expansion of the abnormal haematopoietic clone. PIGA encodes a protein involved in the first step of glycosylphosphatidylinositol (GPI) biosynthesis (2).GPI structures anchor a wide variety of proteins to the cell surface via their lipid moiety. Deficiency of GPI-linked proteins from PNH erythrocytes can be complete (PNH type III cells) or partial (PNH type II cells). The terminology is derived from different complement lysates, sensitivities of the 3 types of PNH erythrocytes, type III being 15 to 25 times more sensitive to complement than normal cells (3).

This variability in the severity of the deficiency, as well as in the proportion of the affected cell population, defines the clinical manifestations of the disease [4-5]. Classical PNH is diagnosed if patients have high LDH and indirect bilirubin with very low concentration of serum haptoglobin, without evidence of any defined bone marrow abnormality. (6) But our patient had all these abnormal investigations along with myelofibrosis, and therefore she can be classified as PNH, in the setting of another bone disorder i.e. myelofibrosis. PNH is a disease of adults presenting in the 3rd to 5th decade of age. In a large series of 78 cases of PNH diagnosed in 10 years, the mean age of diagnosis was 34 years. (7) Age of our patient was 38 years during the diagnosis, which is a common age for this condition.

PNH is associated to venous thrombosis in approximately one third of cases. (8) Venous thrombosis most often occurs in the intra abdominal veins, particularly the hepatic veins. [9-11] PNH results in thrombosis of hepatic veins, leading to hepatic obstruction, thereby increasing the risk of developing BCS in patients. Presenting complaints of many BCS patients were reported to be abdomen pain, distension, and oedema of lower limbs. (12) Our patient also presented with similar complaints. In the series of 78 cases of PNH by Zhao et al, Ham's test was positive in 65.8% cases, whereas CD59 and CD55 were found deficient in 100% of cases. (7) Although both the acidified serum lysis test (Ham test) and the sucrose lysis test (sugar water test) have much biologic and historic importance, they have largely been abandoned as diagnostic assays, because they are both less sensitive and less quantitative than flow cytometry. In our patient, flow cytometry confirmed the deficiency of CD55 and CD59.
The onset of hepatic vein thrombosis in PNH may be insidious or sudden, which is frequent in the setting of a haemolytic episode.(13) Our patient had multiple attacks of thrombosis as DVT and CVA in the past before the attack of BCS, secondary to involvement of the hepatic vein. PNH has been described in the setting of Myelodysplastic (MDS) or myeloproliferative disorders [14- 17], with an incidence ranging from 5 to 9 percent (18) . In a reported study of 44 patients with BCS, almost 7 (6%) patients had myeloproliferative disorders as a causative factor (12). Our patient also had features of Myelofibrosis, as seen by blood film analysis, which showed tear-drop poikilocytes, basophilic stippling and a myelocyte, in addition to the bone marrow finding showing hypoplastic bone marrow with Agnogenic Myeloid Metaplasia with Myelofibrosis, which might have been a causative factor for BCS, along with PNH. The presence of both myelofibrosis and PNH might have enhanced the chance of BCS developing in our patient.

Treatment is based upon pres

Acknowledgement

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References

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Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med 1995; 333:1253-58.
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Takeda J, Miyata T, Kawagoe K, et al. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell 1993; 73:703-11.
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Rosse WF. Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria. Blood. 1990; 75:1595-1601
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Rosti V. The molecular basis of paroxysmal nocturnal hemoglobinuria. Haematologica. 2000; 85: 82-87.
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Tomita M. Biochemical background of paroxysmal nocturnal hemoglobinuria. Biochim Biophys Acta. 1999; 1455:269-86.
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Charles P, Mitsuhiro O, Stephen R, Jun-ichi N, Monica B, Russell W et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 2005; 106: 3699-3709.
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Zhao M, Shao Z, Li K, Chen G, Liu H, Zhang Y. Clinical analysis of 78 cases of paroxysmal nocturnal hemoglobinuria diagnosed in past 10 years. Chin Med J 2002;115: 398-402.
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Graham ML, Rosse WF, Halperin EC, Miller CR, Are RE. Resolution of Budd-Chiarii syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria. Br J Haematol 1996, 92:707-10.
9.
Hartmann, RC, Luther, AB, Jenkins, DE Jr, et al. Fulminant hepatic venous thrombosis (Budd-Chiarii syndrome) in paroxysmal nocturnal hemoglobinuria: Definition of a medical emergency. Johns Hopkins Med J 1980; 146:247.
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Peytremann, R, Rhodes, RS, Hartmann, RC. Thrombosis in paroxysmal nocturnal hemoglobinuria (PNH) with particular reference to progressive, diffuse hepatic venous thrombosis. Ser Haematol 1972; 5:115
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Valla, D, D'Humeaux, D, Babany, G, et al. Hepatic vein thrombosis in paroxysmal nocturnal hemoglobinuria. A spectrum from asymptomatic occlusion of hepatic venules to fatal Budd-Chiarii syndrome. Gastroenterology 1987; 93:569.
12.
Mahmoud. A.E.A, Mendoza.A, Meshikhes.A.N, Olliff.S, West.R, Neuberger.J et al. Clinical spectrum, investigations and treatment of Budd-Chiari syndrome. Q J Med 1996; 89:37–43

Tables and Figures
[Table / Fig - 1] [Table / Fig - 2] [Table / Fig - 3] [Table / Fig - 4]

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