Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Aug 2018

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
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My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
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KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Original article / research
Year : 2010 | Month : June | Volume : 4 | Issue : 3 | Page : 2406 - 2409 Full Version

A Comparison Of Nifedipine With Methyldopa For Control Of Blood Pressure In Mild To Moderate Pregnancy Induced Hypertension.

Published: June 1, 2010 | DOI:
Correspondence Address :
DR.Jagannath Pairu,E.mail:


Objectives: To compare efficacy of nifedipine and methyldopa for control of blood pressure in mild to moderate pregnancy induced hypertension (PIH).
Methods: A comparative study of efficacy of nifedipine and methyl dopa was carried out in 50 pregnant women with pregnancy induced hypertension. Patients were randomly selected who were on either oral nifedipine or oral methyl dopa on a standard dose and blood pressure was measured at 0, 6, 24, 48 and 72 hours of initiation of therapy. Adverse and side effects of drugs were also recorded during this treatment period. Control of blood pressure was assessed in each treatment group by statistical analysis using one way ANOVA followed by Dunnett’s test. P values <0.05 were considered as significant.
Results: The result showed both nifedipine and methyl dopa were equally effective in control of blood pressure. Both treatments were well tolerated with minimal side effects.
Conclusion: Data analysis of the study shows both nifedipine and methyl dopa are equally effective in reducing the blood pressure in pregnancy induced hypertension, nifedipine may be preferred in view of low cost and easy availability.


Pregnancy induced hypertension, nifedipine, methyl dopa.

Hypertensive disorders of pregnancy complicate 5 to 8 % of pregnancies and are a major cause of maternal and perinatal morbidity and mortality(1). Most clinicians commence antihypertensives if BP is more than 140/90 mm of Hg; some start if BP is more than 170/110 mm of Hg.Treating the hypertension does not alter the progression of disease. However it has been shown that early treatment decreases not only the frequency of hypertensive crisis, but also the rate of neonatal complications. The management of pregnancy induced hypertension is mainly termination of pregnancy, which can not be done in many cases due to preterm by gestational age. It is thus prudent to continue the pregnancy till the stage where in the foetal survival is good. During this period the maternal and foetal conditions are monitored along with control of hypertension by antihypertensive drugs. Occasionally pregnancy needs to be terminated due to non control of blood pressure, deterioration of maternal or foetal conditions.

Despite years of research, there remains a lack of consensus on what constitutes an appropriate antihypertensive agent in pregnancy, the maternal-foetal risk-benefit analysis of therapy, short and long term maternal-foetal/neonatal adverse effects, as well as cost effectiveness(2). The agents suggested include methyldopa, nifedipine and labetalol (3),(4). This study compares the efficacy of nifidipine and methyl dopa in control of blood pressure in mild to moderate pregnancy induced hypertension.

Material and Methods

The study was a randomised prospective study and conducted at Kempegowda Institute of Medical Sciences Hospital, K.R.Road, Bangalore-560 004.Ethical clearance was obtained from Ethics committee, Kempegowda Institute of Medical Sciences and hospital, Bangalore.

Inclusion Criteria
All pregnant patients with systolic blood pressure of more than 140 mm of Hg and a diastolic blood pressure of more than 90 mm of Hg on two occasions four hours apart after 20 weeks of gestation admitted in the hospital between July 2006-July 2007.

Exclusion Criteria
1. Severe PIH with imminent eclampsia
2. Heart diseases including IHD.
3. Haematological disorders.
a. Liver diseases.
b. History of intolerance/hypersensitive to dihydropyridine/methyl dopa.

The study group consists of 50 pregnant patients selected on the basis of inclusion and exclusion criteria with pregnancy induced hypertension, according to International Society for the Study of Hypertension in Pregnancy (ISSHP). These patients were further categorised in to two groups based on treatment. Nifedipine group consists of 25 randomly selected patients receiving oral nifedipine in the dose 10mg t.i.d and methyl dopa group with 25 randomly selected patients receiving oral methyldopa 250mg q.i.d. All the patients were inpatients. Besides complete obstetric examination, detailed history was taken, with special attention to hemorrhagic disorders, thromboembolic episode, epilepsy, hepatic or renal disorder and drug intake. Blood samples were taken for estimating Hb%, total and differential white cell counts, blood sugar, blood urea, serum uric acid and total platelet count. Foetal kick count chart, and ultrasound, fundoscopy, cardiotocography, and Doppler ultrasound were also done. Blood pressure was recorded using Mercury Spygmomanometer with patient in 15 degrees left lateral recumbent position. Korotkoff V sound was used for determining diastolic blood pressure (5).Blood pressure was recorded at 0, 6, 24, 48 and 72 hours of initiation of antihypertensive treatment. Side and adverse effects of the drugs were also recorded. Control of blood pressure was assessed in each treatment group by statistical analysis using one way ANOVA followed by Dunnett’s test. P <0.05 were considered as significant.


The two groups on admission to the study had almost similar periods of gestation (Table/Fig 1). Both group had similar blood pressure recordings at the initiation of therapy i.e., mean systolic blood pressure and mean diastolic blood pressure in mm of Hg (Table/Fig 2), (Table/Fig 3). When systolic blood pressure was compared between the groups after initiation of antihypertensive therapy, a rapid fall in systolic blood pressure was observed at 6 hours in both groups, but was significant with p<0.01 only in nifedipine group.

However systolic blood pressure was controlled significantly in both groups at the end of 24 hours with p<0.01.Reduction progressed further and systolic blood pressure was almost normal i.e., below 140 mm of Hg in both groups by the end of 42 hours and was maintained up to 72 hours(Table/Fig 2).

Almost similar results were obtained when diastolic blood pressure was compared between the groups. A significant fall in diastolic blood pressure was observed in both groups at 24 hours of initiation of antihypertensive therapy with p<0.01 and was maintained normotensive up to 72 hours of treatment(Table/Fig 3).

When side effects were compared between the groups (Table/Fig 4) observed during the treatment period (up to 72 hours), head ache was the most common side effect recorded in nifedipine group and palpitation in methyl dopa group. Dizziness and weakness were observed only in methyl dopa group and not in nifedipine group.

However 32% and 36% of patients did not show any side effects in methyl dopa group and nifedipine group respectively. There were no adverse effects observed in both groups during the treatment period.


The aim of antihypertensive therapy in the management of pregnancy induced hypertension is to prevent complications due hypertension while prolonging the course of pregnancy. It is generally indicated that severe hypertension (systolic blood pressure > 169 mm of Hg and diastolic blood pressure >109 mm of Hg) require antihypertensive therapy. But in mild and moderate hypertension the need for antihypertensive therapy is to prevent progression to severe hypertension. The commonly used antihypertensive drugs in pregnancy are nifidipine, methyl dopa, labetolol and hydralazine (4). Most of these drugs are quiet safe for mother and foetus (6),(7). The aim of antihypertensive therapy is to achieve a blood pressure lower than 170/110 mm of Hg but not lower than 130/90 mm of Hg without compromising uteroplacental blood flow and placental perfusion (8).

In this study the efficacy of nifidipine and methyldopa in controlling blood pressure in patients with mild to moderate pregnancy induced hypertension were studied. These drugs have different mode of action, nifedipine is calcium channel blocker and methyl dopa is centrally acting drug which inhibits sympathetic outflow. The pathophysiology of pregnancy induced hypertension is centred on vasospasm due to various factors like increased pressor response, vasoactive agents, endothelial damage, inflammatory response, genetic predisposition and immunological factors.Inspite of these varied pathophysiology and different mode of action of nifedipine and methyl dopa, both the drugs were effective in controlling the pregnancy induced hypertension with minimal side effects (9),(10),(11),(12). These studies were with use of either nifedipine or methyldopa separately as individual study on various aspects of hypertension in pregnancy ,but not comparative with respect to efficacy. In the present study patients were randomly treated with nifedipine or methyldopa simultaneously, efficacy was assessed based on control of blood pressure up to 72 hours. It was found that both nifedipine and methyldopa were equally effective in controlling mild to moderate blood pressure in pregnancy. Therapeutic goal was achieved in both the groups by 24 hours of initiation of therapy. When we consider undesirable side effects between the groups, they were found to be minimal and well tolerated. Also there were no incidences of adverse effect. Nifedipine may be preferred in view of low cost and easy availability.

As this study was to access the efficacy of the drugs to control blood pressure in pregnancy, a long term study for the effects of these antihypertensives on the both mother and new born is desired.


The authors thank the Principal, Kempegowda Institute of Medical Sciences, Medical Superintendent, KIMS Hospital and Professor HOD, Dept. of OBG, Kempegowda Institute of Medical Sciences, K.R.Road, Bangalore-560 004 for permitting to conduct this study.


Diagnosis and management of preeclampsia and eclampsia. ACOG Practice Bulletin 2002; 33:1-14.
Abalos E, Duley L, Steyn DW, Henderson-Smart DJ. Antihypertensive drug therapy for mild to moderate hypertension during pregnancy (Cochrane Review).Cochrane Database Syst Rev 2007; 24(1):CD002252.
National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183(1):S1-22.
Rey E, LeLorier J, Burgess E, Lange IR, Leduc L. Report of the Canadian Hypertension Society Consensus Conference: 3.Pharmacologic treatment of hypertensive disorders in pregnancy. CMAJ 1997; 157(9):1245-54.
Brown MA,Buddle ML,Farrell T. Randomised trial of management of hypertensive pregnancies by Korotkoff phase 4 or phase 5? Lancet 1998; 352:777-81.
Khedun S M, Maharaj B, Moodley J. Effects of antihypertensive drugs on the unborn child what is known, and how should this influence prescribing? Paediatric Drugs 2000; 2(6): 419-36.
Yankowitz, Jerome. Pharmacological treatment of hypertensive disorders during pregnancy, Journal of Perinatal and Neonatal Nursing 2004; 18(3): 230-40.
Naden RP, Redman CW. Antihypertensive drugs in pregnancy. Clin Perinatol 1985; 12(3): 521-38.
Fenakel K, Fenakel G ,Zvi A, Lurie S, Zvi K, Shoham Z. Nifedipine in the treatment of severe preeclampsia. Obstetrics and Gynaecology 1991; 77(3): 331-7.
Brown MA, Buddle ML, Farrell T, Davis GK. Efficacy and safety of nifedipine tablets for the acute treatment of severe hypertension in pregnancy. Am J Obstet Gynecol 2002; 187(4):1046-50.
Weitz C, Khouzami V, Maxwell K, Johnson JW. Treatment of hypertension in pregnancy with methyl dopa: a randomised double blind study. Int J of Gynaecol Obstet. 1987; 25(1):35-40.
Montan S, Anandakumar C, Arulkumaran S,Ingemarsson I,Rathnam SS. Effects of methyl dopa on uteroplacental and fetal hemodynamics in pregnancy-induced hypertension. Am J Obstet Gynecol 1993; 168(1): 152-6.

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