Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida
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"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."



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Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
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Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
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Professor and Head
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Saraswati Dental College
Lucknow
On Sep 2018




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Calcutta National Medical College & Hospital , Kolkata




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On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011

Important Notice

Original article / research
Year : 2010 | Month : October | Volume : 4 | Issue : 5 | Page : 3095 - 3099

Gender Variation Of Somatic Symptoms Of Depression As Possible Indicators Of Its Diagnosis And Severity

RAMESH MG*, SATHIAN B**, SHREEVATSA BM***, BEDANTA R****, RAMESH K*****, BUDHACHANDRA Y******, BABOO NS*******

*BPT. M.Sc. (Medical Physiology), Lecturer, ** PhD (Biostatistics) Assistant Professor, *** M.Sc (Physiology), Lecturer, **** M.Sc (Physiology) Assistant Professor, ***** MD (Psychiatry), Professor, ****** MSc. PhD (Psychology) Lecturer, ******* MD (Physiology), Professor

Correspondence Address :
M.G.Ramesh Babu BPT. M.Sc.,
Lecturer, Department of Physiology,
Kasturba Medical College – International Center.
Manipal University Campus, Manipal.
Udupi District.
Karnataka. India.
Phone No: 9611362075
Email: ramesh.babu@manipal.edu,
rameshmg@yahoo.com.

Abstract

Depression is a common mental health problem around the world and is responsible for a wide range of problems in all the aspects of a person’s functioning. It is the 4th in the list of the most urgent health problems worldwide, as per the World Health Organization (WHO) and its lifetime prevalence is around 10-25% for women and 5-12% for men. Several studies estimate the prevalence for major depression as around 5%, making it one of the most common clinical problems. Among them, only around 10% are referred to psychiatric services and get treated, but many others suffer in silence and solitude. The present study was carried out in 131 patients who were diagnosed as having depression according to the Structured Clinical Interview for ICD. The Beck Depression Inventory (BDI) was routinely administered as part of the standard intake assessment battery. When patients scored >1 on each of the four somatic BDI items, they were considered as having moderate to severe somatic depression. Descriptive statistical methods and confidence intervals were used to find out the severity of the symptoms among males and females. There were 65 (98.5%) females and 56 (94.9%) men who could be classified as having somatic depression and 1 (1.5%) female and 3 (5.1%) men who were classified as having non-somatic depression. The somatic symptoms of depression are always associated with the pathophysiological changes in the brain. There are evidences that changes in the cortisol, nor adrenalin (NE) and serotonin activities cause abnormal physiological activity of the brain, which is responsible for the somatic symptoms in depression. In the present study, a significant difference was found in appetite and fatigue in moderate to severely depressed female patients than in the males. Therefore, the somatic symptoms can be considered as indices while diagnosing depressive disorders.

Keywords

Depressive disorders, somatic depression, diagnosing depressive disorders

Introduction:
Depression is a common mental health problem around the world and is responsible for a wide range of problems in all the aspects of a person’s functioning(1). It is the 4th in the list of the most urgent health problems worldwide, as per the World Health Organization (WHO) and the lifetime prevalence is around 10-25% for women and 5-12% for men(2). It is also called as unipolar-depression, which may manifest as a single episode or recurrent episodes and usually, the age of onset of depression is around 28 yrs, but the first episode can occur almost at any age(3). Several studies have estimated the prevalence for major depression as around 5%, making it one of the most common clinical problems. Among them, only around 10% are referred to psychiatric services(4) and get treated, but many others suffer in silence and solitude.(5) The major depressive disorder is widely distributed and is usually associated with substantial symptom severity and functional impairment(6). There is a positive and strong association between the severity of depressive illness and somatic symptoms(7),(8). A study in Asian ethnic groups reveals that non-affective symptoms in depression have large health and functional significance and important implications for the diagnosis and management of depression among the elderly in primary care(9). Approximately two thirds of the patients with depression present with somatic symptoms at the primary care centres(10). It was reported that the female to male ratio of the somatic symptoms was approximately 2:1(11). This study aims to evaluate the utility of the gender variation in self-reported somatic symptoms as indicators for the diagnosis and staging of depression as measured by the Beck Depression Inventory (BDI)(12).

Material and Methods

An observational descriptive study was conducted during the years 2006-2007, on patients who reported to the psychiatric out patients department in the Department of Psychiatry, Manipal Teaching Hospital (MTH), Pokhara, Nepal. The study was carried out with permission from the hospital ethical committee. Verbal consent was taken from the patient or the patient’s relatives. The study includes 131 patients (male=64 and female=67) who were diagnosed as having unipolar depression according to the Structured Clinical Interview for ICD-10: Classification of Mental and Behavioural Disorders - Diagnostic Criteria for Research(13). The Beck Depression Inventory (BDI) was routinely administered as part of the standard intake assessment battery. It is a 21-item self-report depression scale. Overall, the scores of this scale range from 0 to 63, which is obtained by summing the severity of individual symptoms rated from 0 to 3. The somatic symptoms of the BDI items consist of sleeping patterns, appetite, fatigue and weight loss. A patient was classified as having somatic depression if he or she rated all four of these items as >1 on the 0–3 rating scale. If the rating for any of these items was 0 or 1, then the patient was classified as having non-somatic depression. This strategy identified patients with somatic depression whose severity ranged from moderate to severe, which is similar to the Amy Wenzel definition of somatic depression(14). The total number of patients (n=131) [mean (SD) age, 32.53(12.50) years and (30.39, 34.67 CL)] who reported to the psychiatric department were divided into two groups as males (n=64) [mean (SD) age, 33.31(13.75) years and (29.94, 36.67 CL)] and females (n=67) [mean (SD) age, 31.79(11.24) years and (29.10, 34.48CL)].
Statistical Methods:
Descriptive statistics methods and confidence intervals were used to find out the severity of the symptoms among males and females. The χ2 test was used to detect the differences in the presence or absence of the symptoms of somatic depression as a function of gender. The Yates correction for the χ2 test was applied to correct the problems with the discontinuity of the χ2 distribution, when two dichotomous variables were being compared. The Fisher’s exact test (φ value) was used for testing the null hypothesis of independence for categorical data. The statistical software SPSS 16.0 version and the Epi-Info windows version were used for the assessments.

Results

The patients who scored >1 on each of the four somatic BDI items were considered as having somatic depression and among the somatic depressive subjects, 56 (94.9%) were males and 65 (98.5%) were females. Among them, 3 (5.1%) were males and 1 (1.5%) was a female. The index of somatic depression was χ2 Yates (N =131) = 0.3881, p >.05, φ=.27. The odds of a female, as opposed to that of a male, describing somatic depression was 0.2872; 95% Confidence Level 0.029–2.839 and the risk ratio was 0.2980, with 95% Confidence Level 0.0319 - 2.7873. It showed no significant difference. Further analyses were performed to determine whether all four of the symptoms used in defining somatic depression did vary in males and females. Change in sleeping patterns, χ2 Yates (N =131) = 0.0196, p >.05, φ=.44 and weight loss, χ2 Yates (N =131) = 0.0178, p >.05, φ=.55 did not discriminate the females from the males. But, the females were discriminated from the males on the basis of both the items, appetite, χ2 Yates (N =131) = 9.3700, p <.05, φ=.0009 and fatigue, χ2 Yates (N =131) = 6.9318, p < .05, φ=.004, which is shown (Table/Fig 1).

Discussion

The most common somatic symptom reported by the patients with moderate or the above levels of the major depressive disorder (MDD) was feeling fatigued, weak or tired, all over(15). Significant differences were found for increased appetite and weight in 498 moderately to severely depressed patients with unipolar MDD(16). In an American epidemiological study in the subjects of different race, ethnicity and gender, significant differences were found in appetite and weight(17). By considering age and gender, the level of fatigue and depression was found to be higher among young adult women and middle-aged men(18). Overweight was strongly associated with depression in adolescent females(19). Migraine was found to be strongly associated and was an independent predictor with more somatic symptoms in patients with MDD(20). In a cross cultural study, it is reported that Japanese had higher levels of somatic distress than the Americans(21). In the present study, it was found that there was no significant difference between the males and females who were categorized as having moderate to severe cases of somatic depression. When considering the four somatic items of BDI, appetite and fatigue showed significant difference, which is shown in (Table/Fig 2) and it was particularly salient in females as compared to their other symptoms. This indicates that the BDI items, appetite and tiredness were useful in detecting moderate to severe cases of somatic depression in females. It supports the view that there are gender differences in somatic depression as assessed by the BDI.

Generally, somatic symptoms such as fatigue, weakness, and pain are associated with depression(22) and may reflect underlying neurobiological abnormalities(23),(24). The finding of a significant increase in appetite and fatigue in females with MDD in the present study indicates some biological factors which may be causing the gender differences in depression. Research evidences which have accumulated over the past 20 years indicate that corticotropin-releasing factor (CRF) plays a role in the pathophysiology of MDD(25). The increased and decreased activities of CRF and cortisol were found in melancholia and in atypical depression, respectively(26). MDD was first shown to involve the peripheral components of the hypothalamo–pituitary–adrenal axis when increased serum cortisol was demonstrated at all hours of the circadian rhythm in endogenously depressed subjects as compared to the non-depressed subjects(27). Elevated amounts of tyrosine hydroxylase(28),(29) and reduced amounts of norepinephrine (NE) transporter binding(31) in the locus ceruleus have been reported in major depressive subjects as compared to the psychiatrically normal control subjects. The neurotransmitters, serotonin and NE, that influence both pain and mood, have deeper biological connections with depression(31). Fluctuations in both mood and appetite which are associated with changes in the levels of neurotransmitters such as serotonin were seen in both men and women(32), but this can be exacerbated by changes in the balance between oestrogen and progesterone levels that a woman experiences at different stages of her menstrual cycle(33). A functional decrease of serotoninergic neurotransmission was reported in insomnia associated with depression.(34)

Conclusion

From foregoing, it is obvious that the somatic symptoms of depression are always associated with the pathophysiological changes in brain. There are evidences that changes in the cortisol, NE and serotonin activities cause abnormal physiological activity of the brain, which is responsible for the somatic symptoms in depression. Strong evidence for the involvement of CRF circuits in the production of depressive symptoms was also found in reports of CRF receptor antagonists having antidepressant effects(35). Therefore, the somatic symptoms can be considered as indices while diagnosing depressive disorders. In the present study, a significant difference was found in appetite and fatigue in moderate to severely depressed female patients than the males in Pokhara. However, similar studies should be done in a large patient population to establish this finding.

Acknowledgement

The authors would like to thank Professor Dr C.G.Saha MD (Physiology), Professor, Department of Physiology, Manipal College of Medical Sciences, Pokhara, Nepal, for his support and valuable advice to carry out this study.

References

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Soh KC, Kua EH, Ng TP. Somatic and non-affective symptoms of old age depression: ethnic differences among Chinese, Indians and Malays. Int J Geriatr Psychiatry. 2009 Jul;24(7):723-30.
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Tylee, Gandhi. The important of somatic symptoms in depression in primary care. Prim Care Companion J Clin Psychiatry. 2005;7(4):167-76.
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Cyranowski JM, Frank E, Young E, Shear MK. Adolescent onset of the gender difference in lifetime rates of major depression: a theoretical model. Arch Gen Psychiatry. 2000 Jan;57(1):21-7.
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Devilly, G.J. (2004). Assessment Devices. Retrieved March 24, 2004, from Swinburne University, Clinical and Forensic Psychology. Available on; Web site: www.swin.edu.au/victims/resources/assessment/assessment.html
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Wenzel A, Steer RA, Beck AT. Are there any gender differences in frequency of self-reported somatic symptoms of depression? J Affect Disord. 2005 Dec;89(1-3):177-81. Epub 2005 Oct 3.
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Vaccarino AL, Sills TL, Evans KR, Kalali AH. Prevalence and association of somatic symptoms in patients with Major Depressive Disorder. J Affect Disord. 2008 Oct;110(3):270-6. Epub 2008 Feb 15.
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