Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
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Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Case report
Year : 2011 | Month : April | Volume : 5 | Issue : 2 | Page : 361 - 363 Full Version

Salivary duct carcinoma of the minor salivary glands: A rare case report

Published: April 1, 2011 | DOI:

G Pulla Reddy Dental College and Hospital, Kurnool, AP, India

Correspondence Address :
Dr Rajini Kanth M, Associate Professor,
G Pulla Reddy Dental College & Hospital, Kurnool,
Andhra pradesh, India
E mail address:


Salivary duct carcinoma (SDC) is a rare invasive malignancy arising in the ductal epithelium of the salivary glands. These are an uncommon but distinct group of highly malignant salivary gland tumours. These are usually seen in the major salivary glands, especially in the parotid gland. This malignancy was established as a distinct clinicopathological entity and was delineated from ‘’adenocarcinoma (NOS)” in 1991 by the World Health Organization. Salivary duct carcinomas affecting the minor salivary glands have been reported in only 4% of the SDC cases and constitute 2% of all the salivary gland malignant neoplasms. Its biological behaviour is highly aggressive; the metastatic and the tumour-related death rates were 75% and 73%, respectively. In this article, wereport a case of a salivary gland carcinoma which was present in the palate of a 55-yearold male patient.


Duct Carcinoma, minor salivary glands

Case Report

A 55-year-old male patient was referred with a complaint of growth in the left upper posterior region of the maxilla for the past 4 months. He was apparently healthy and no abnormalities were detected on extra oral examination. On intra-oral examination, a non tender, dome shaped, ulcerated swelling was seen extending from the upper left second premolar on the buccal side to the first molar region. The lesion was 3 x 3 cm in size, erythematous and with irregular margins. On the lingual side, a hard mass was present since 30 years.(Table/Fig 1) On palpation, the lesion was found to be tender and soft to hard in consistency. No lymph nodes were detected. The orthopantamogram revealed a wide area of bone loss in the upper left molar region.(Table/Fig 2) A provisional diagnosis of peripheral giant cell granuloma and squamous cell carcinoma/ mucoepidermoid carcinoma was given, based on the clinical details. An incisional biopsy was performed under local anaesthesia and the specimen was sent for histopathological evaluation. The histopathological features of the lesion revealed numerous infiltrating islands and cords of neoplastic glandular epithelium in a fibrovascular connective tissue. Most of the neoplastic islands exhibited central “comedonecrosis (Table/Fig 3).. The neoplastic cells were cuboidal to polygonal in shape and exhibited cellular pleomorphism, eosinophilic cytoplasm, nuclear hyperchromtism and prominent nucleoli (Table/Fig 4). Numerous blood vessels and mitoses were present. The lesion was covered by a parakeratinized, stratified squamous surface epithelium. Based on the histopathological features, a diagnosis of salivary duct carcinoma was made.


SDC was first described by Kleinsasser in 1968 (1) and was further defined by several authors. It was only recently recognized as a distinct clinic-pathological entity. The origin of the neoplasm from the salivary ducts was initially suggested by its morphological resemblance to mammary duct carcinoma and it was later supported by the identification of preinvasive disease, ductal dysplasia and carcinoma in situ in the intralobular and the extralobular ducts.(2) (3) Salivary ductal carcinoma occurs predominantly in males, with a male to female ratio of 2:1. The ages of these patients ranged from 23-80 years, with more cases being reported in the fifth and sixth decades of life. These are usually seen in the major salivary glands, especially in the parotid gland. (4) Salivary duct carcinoma affecting the minor salivary glands has been reported in only 4% of the SDC cases and constitutes 2% of all the salivary gland malignant neoplasms. Intra-orally, the common sites of occurrence are the palate, followed by the buccal mucosa / vestibule, the upper lip, the maxilla and the mandible. (5) Salivary duct carcinoma, which was recently recognized as a high grade, aggressive malignancy of the major salivary glands, is characterized histologically by a striking resemblance to ductal carcinoma of the breast. The terms, ‘cribriform salivary carcinoma of the excretory duct’ and ‘infiltrating salivary duct carcinoind’ have been recommended for SDC, to distinguish it from other salivary carcinomas, many of which may also be “ductal” in origin.’” However, the designation, ‘salivary duct carcinoma’ has gained acceptance because it is used in the WHO classification of tumours.” The separation of SDC from the category, “adenocarcinoma NOS (not otherwise specified)”, is warranted by its predictably aggressive behaviour. (4) This tumour may arise within a pleomorphic adenoma as a result of the malignant transformation of the ductal epithelial cells. In addition, a multifocal origin from the major excretory ducts surrounding a pleomorphic adenoma was observed in one of the cases. SDC exhibits a wide range of histological appearances. (3) The histopathological features of SDC consist of atypical cuboidal or polygonal cells which are arranged in papillary cribriform and solid growth patterns along with duct like structures. The tumour cells are polygonal in shape, with granular eosinophilic cytoplasm, enlarged hyperchormatic, pleomorphic nuclei and prominent nucleoli. Pseudocyst formation and central comedonecrosis are seen in the neoplastic islands. (‘Comedonecrosis’ means a type of necrosis occurring in the glands, in which there is central luminal inflammation with devitalized cells, which usually occurs in the breast in intraductal carcinoma). Vascular invasion and perineural infiltration have been reported in some cases. Atypical mitotic figures are seen in most of the lesions. Dystrophic calcifications are seen in some cases. The differential diagnosis of SDC (6), (7), spans a range of low-grade and high-grade salivary gland malignant neoplasms, the most common ones of which include papillary cystadenocarcinoma, papillary cystic acinic cell carcinoma, metastatic adenocarcinoma, etc. Lymph node metastases have been reported in 22% of the SDC cases in the minor salivary glands, as compared to 83% in the SDC of the major salivary glands. However, multiple metastases and a high mortality rate of 60-75% are associated with the minor salivary gland SDCs. A recurrence rate of 33-35% has been reported from a study on SDC patients.(8), (9) (10). . The treatment of this lesion involves the radical surgical excision of the lesional tissue and its associated structures, with concomitant neck dissection, followed by post-operative radiation therapy.


. Kleinsasser O, Klein ILL Hubner G. Speichelgangcarcinome. Fin den Milchgancarcinomen der Brustdruse analoge Gruppe von Speicheldrusentumoren. Arch Klin Exp Ohren Nasen Kehlkopfheilkd, 1968; 192:100-5.
. Margaret S. Brandwein, Jaishree Jagirdar, Jaygonda Patil, Hugh Biller and Mamoru Kaneko. Salivary Duct Carcinoma (Cribriform Salivary Carcinoma of Excretory Ducts) A Clinicopathologic and Immunohistochemical Study of 12 Cases. Cancer 1990; 65: 2307-2314,
. Ruby Delgado, Frank Vuitch and Jorge Albores-Saavedra, Salivary Duct Carcinoma: Cancer 1993; 721503-12.
. Nalin Kumar S, Ranganathan K, Nathan JA, Saraswathi TR. Salivary duct carcinoma of minor salivary gland. J Oral Maxillofac Pathol 2004; 8:87-90
. Lewis, J. E., McKinney, B. C., Weiland, L. H., Ferreiro, J. A. and Olsen, K. D. Salivary duct carcinoma: Clinicopathologic and immunohistochemical review of 26 cases. Cancer, 1996; 77: 223–230.
. Crawford Anderson, Richard Muller, Robert Piorkowski, David R. Knibbs,Paul Vignoti. lntraductal Carcinoma of Major Salivary Gland. Cancer 1992; 69609-614
. Ken Motoori, Yumiko Iida,Yuichirou Nagai, Seiji Yamamoto, Takuya Ueda Hiroyuki Funatsu Hisao Ito and Okamoto Yoshitaka : MR Imaging of Salivary Duct Carcinoma. American Journal of Neuroradiology 2005;26:1201-1206,
. Jean E. Lewis, Barbara C. McKinney, Louis H. Weiland, Jorge A. Ferreiro M.D, Kerry D. Olsen: Salivary duct carcinoma: Clinicopathologic and immunohistochemical review of 26 cases. Cancer. 1996,Volume 77, Issue 2, pages 223–230, 15
. Cheuk, Wah, Miliauskas, John R, Chan, John K.C. Intraductal Carcinoma of the Oral Cavity: A Case Report and a Reappraisal of the Concept of Pure Ductal Carcinoma in Situ in Salivary Duct Carcinoma: American Journal of Surgical Pathology: 2004 - Volume 28 - Issue 2 - pp 266-270
. Ponniah I, Murali GM, SureshKumar P, Kumaran MG, Shaheen A. Salivary duct carcinoma of the palate. Indian J Dent Res 2005;16:167

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