Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
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Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Case report
Year : 2011 | Month : October | Volume : 5 | Issue : 5 | Page : 1117 - 1119 Full Version

Necrotizing Fasciitis of the Breast with Shock and Postpartum Psychosis

Published: October 1, 2011 | DOI:
Vishwanath G., Basarkod S.I., Geetanjali M. Katageri, Promod Mirji, Ashok S. Mallapur

Corresponding Author. Dr. Basarkod S.I. (MBBS, MS Surg.) Assoc. Prof., Dept. of Surgery S.N.Medical College, Bagalkot, Karnataka. Dr. Geetanjali M. Katageri (MBBS, MS OBG) Assoc. Prof., Dept. of OBG S.N.Medical College, Bagalkot, Karnataka. Dr.Pramod Mirji (MS), Dept of Surgery Assistant Professor SN Medical college, Bagalkot, Karnataka.Dr. Ashok S Mallapur (MS FAIS) Professor & Principal, Dept of Surgery, SN Medical college, Bagalkot, Karnataka.

Correspondence Address :
Vishwanath G. (MBBS, MS Surg.)
Assoc. Professor, Dept. of Surgery,
S. Nijalingappa Medical College,
Bagalkot, Karnataka - 587102.
Phone: 08722336344


Necrotizing fasciitis (NF) is a rapidly progressive infection of skin and subcutaneous tissue with high morbidity. NF is frequently found with trauma, bites, surgery, IV drug abuse, diabetes and immune compromised patients. . NF involving the breast is not common. Delay in differentiating NF from puerperal mastitis leads to increased morbidity or loss of breast tissue to variable extent. We report a case of NF of the breast in shock with postpartum psychosis necessitating mastectomy.


Necrotizing fasciitis, Breast, Postpartum psychosis

Puerperal breast infections encompass mastitis, abscess, and rarely necrotizing fasciitis (1). Early diagnosis and appropriate intervention are vital for preservation of breast tissue. However, in rural India, women seeking care late is the rule rather than the exception as they first resort to local remedies and present with advanced infection. Hence breast abscesses are commonly encountered in clinical practice. A much rarer clinical entity is Necrotizing Fasciitis of the breast. It has been reported after various primary triggering factors like needle biopsy, surgery, implants, trauma etc. (2) but to our knowledge, it has never been reported after a breast abscess. Delayed diagnosis of NF is associated with increased sepsis, MODS and mortality. We present one such case.

Case Report

Mrs. X, 20 year old P2L1 delivered 20 days back at home reported to OPD with complaints of discoloration and purulent discharge from right breast since one week. The baby had died one week after delivery following which she had fever and painful swelling of the right breast. She had taken treatment at a peripheral health facility for the same. She then developed abnormal behaviour for which she was taken to traditional healers. Meanwhile, she developed discoloration and purulent foul smelling discharge from the right breast and was brought to HSK Hospital (Table/Fig 1).

On examination, the patient was drowsy, febrile and pale with a pulse of 100/min. and a B.P. of 96/60 mm of Hg. There was blackish discoloration of skin over the right breast and adjacent chest wall. There was edema of the skin over the back up to the midline (Table/Fig 1). There were 2 sinuses discharging pus, one at the anterior axillary line and another at the posterior axillary line. Her investigations revealed a Hb of 6.5 gm%, WBC count of 14,600/ mm3, B. Urea 87 mg/dl, S. Creatinine 1.9 mg/dl, RBS 109 mg/dl, S.Potassium 4.6 meq/l, S.Sodium 133 meq/l and S.Chloride 198 meq/l.

Patient resuscitated with i.v. fluids, ianotropes, nasal O2 inhalation. She was commenced on broad spectrum intravenous antibiotics (piperacillin and tazobactum with metronidazole) and transfused one unit of blood. A diagnosis of Necrotizing Fasciitis was made and the patient was taken up for debridement under generalanaesthesia. Per operatively, the breast tissue was found necrosed and the subcutaneous fat, fascia necrosed with thrombosed veins with foul smelling discharge. Wide resection comprising right mastectomy and excision of all necrotic tissue was done. Wound inspection was done after 48 hours with minor debridement (Table/Fig 2). Histopathological examination of the specimen confirmed the diagnosis (Table/Fig 3).

Postoperatively, the patient improved with blood transfusions and antibiotics according to the sensitivity report. Once her condition improved, it unmasked her abnormal behaviour. A Psychiatrist’s opinion was sought and she was diagnosed to have postpartum psychosis with mania and treatment was started for the same. After 2 weeks, when healthy granulation tissue was noted, split thickness skin grafting was done which took up well. Two months after first admission, the patient visited the OPD for follow up. The patient was doing well and the wound had healed.


The term Necrotizing fasciitis (NF) was coined by Wilson in 1952. Necrotizing soft tissue infection (NSTI) is a rapidly progressive spreading necrotic infection of skin, subcutaneous tissue, fascia and muscle.

Predisposing factors include history of blunt trauma, varicella (chickenpox), injection drug use, penetrating injury, insect bites, surgical procedures, child birth, burns, DM, peripheral arterial disease, malignancy and immunosuppression (2).

Two types of NF have been described. Type 1 is polymicrobial, commonly gram positive and negative anaerobes and associated with DM, PVD. Type 2 is monomicrobial, commonly being GAS.(10) Giuliano et al showed that 77% of patients had a combination of facultative organisms and anaerobes isolated and that a synergistic action between the two could explain the fulminant course of the disease (4),(10).

Early diagnosis is not always possible, because signs such as erythema, tenderness, swelling, and fever accompany other inflam- matory states of skin and subcutaneous tissue (e.g., cellulitis). Large haemorrhagic bullae, skin necrosis, sensory deficits & crepitus (hard signs) are all late features (3), (8). Lack of specific clinical features and characteristics in the early stages of the disease is the main reason for delay in recognition and treatment of NSTI resulting in life threatening sepsis with a mortality of 29% (5),(8),(10) Various laboratory parameters, scores (LRINC), ultrasonography, tissue O2 saturation, frozen section study have been proposed to aid in diagnosis (5),(6),(7) but high clinical suspicion remains the corner stone of early diagnosis. Early diagnosis and aggressive treatment of NF has reduced morbidity and mortality (9), (10).

In these conditions adherence to the following plan may be advocated: (2), (3), and (10)

1. Early surgical referral of patients with atypical cellulites and pain disproportionate to the area of involvement. 2. Prompt resuscitation with intravenous fluids, broad spectrum antibiotics and analgesia. Early involvement of intensive care unit .

3. Diagnostic incision of the affected site to inspect the underlying fascia should be performed at the earliest opportunity, with pus sent for urgent Gram stain and culture. 4. Radical ‘pseudotumour’ excision of all the involved tissues should be performed immediately. 5. Wound should be inspected under anaesthesia at 48 hours to confirm the adequacy of the excision. 6. Once clearance of devitalised tissue has been achieved, reconstructive measures aimed at skin closure can be commenced.

In this case early diagnosis and treatment would have saved the breast. In such cases lack of awareness and delay in seeking medical care due to socio-economic factors contribute to increased morbidity.The treating physician should be aware of the spectrum of breast infections in the postpartum period.


1] McAdoo GL, Monif GR. Expanding disease spectrum associated with puerperal mastitis. Infect Dis Obstet Gynecol. 1997;5(6):376-9.

Shah J, Sharma AK, Johri A, Mearns B, O’Donoghue JM, Thomas VA et al. British Journal of Plastic SurgeryNecrotizing fasciitis of the breast. 2001 ; 54( 1): 67-68.
Korhan Taviloglu* and Hakan Yanar .Necrotizing fasciitis: strategies for diagnosis and management. World Journal of Emergency Surgery 2007, 2:19. doi:10.1186/1749-7922-2-19.
Giuliano A, Lewis F Jr, Hadley K, Blaisdell FW. Bacteriology of necrotizing fasciitis. Am J Surg 1977; 134: 52-7
Derek B. Objective criteria may assist in distinguishing necrotiz-ing fascutis from non necrotizing soft tissue infection. Am J Surg 2000; 179:17-20.
Wong CH, Khin LW. The LRINEC (Laboratory risk indicator for necrotizing fasciitis)score : A tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med 2004; 32(7): 1535-41
Su YC, Chen HW, Hong YC, Chen CT, Hasiao CT. Laboratory risk indicator for necrotizing fascitis score and the outcomes. ANZ J Surg 2008;78:968-72.
Elliot DC, Kufera JA, Myer RA. Necrotizing soft tissue infection : risk factors for mortality and strategies for management. Annals of Surgery 1996; 224: 672-83.
Mc Henry CR, Piotrowski JJ, Petrinic D, Malangoni MA. Determinant of mortality in necrotizing soft tissue infections. AnnSurg1995;221: 558-56.
Gurpreet Singh, Sunil K Sinha, Shailesh Adhikary, K Srinivas Babu, Pallab Ray, Satish K Khanna et al. Necrotising infections of soft tissues – a clinical profile, European Journal of Surgery 2002;168(60):366-71.

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