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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
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Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Case report
Year : 2011 | Month : December | Volume : 5 | Issue : 8 | Page : 1648 - 1650 Full Version

Tubercular osteomyelitis– rare presentation of MDR–TB in a child –a case report

Published: December 1, 2011 | DOI:
Hemavathi, Leela Rani, Sandhya Belwadi

1. Corresponding Author 2. MD, Department of Microbiology, Vydehi Institute of Medical sciences, White field, Bangalore- 560600 3. MD, Department of Microbiology, Vydehi Institute of Medical sciences, White field, Bangalore- 560600

Correspondence Address :
No. 12 Mount Veiw Enclave, Bettahalasur cross
Bangalore North – 562157 Karnataka
Ph.: 9886218454


Abstract: Tuberculosis is a major public health problem in the world. As such, the scenario is quite alarming and it has further been complicated by the spread of the Human Immunodeficiency virus (HIV), as well as by the increased drug resistance. We report here about a child who was previously treated for pulmonary tuberculosis and later on developed skeletal tuberculosis, who did not respond to the first line anti tubercular drugs. Later on, genotyping was done and the diagnosis was found to be Multi Drug Resistant Tuberculosis (MDR-TB). She was started on the 2nd line of anti tubercular drugs since 6 months and is doing well.


Tubercular osteomyelitis/ Child/ MDR- TB

The WHO (2008) – estimate reveals 9.4 million incident cases of tuberculosis globally with 11.1 million prevalent cases, 0.5 million cases of MDR-TB and 0.15 million deaths which are associated with MDR-TB. There are about 50,000 cases of extensively drug resistant TB (XDR-TB) and 30,000 deaths are associated with XDR-TB. The emergence of drug resistance has become a serious problem worldwide; more efforts are needed to tackle this deadly disease which may become a global emergency (1). Drug susceptibility tests are a must for all the re- infection/treatment failure cases, as MDR-TB and XDR-TB are more likely to occur in patients who have been previously treated for tuberculosis.

Case Report

An apparently healthy looking, active child of the age of 1yr 6mths from West Bengal came to a medical college hospital in White Field, Bangalore, with a history which was given by her mother as a swelling in the right posterior aspect of the elbow, measuring about 4x4cms in size and it was non-tender and non-mobile. The child complained of pain since 2 days. Next day, redness was seen over the swelling, with no restriction of her movements.

Past history-when the child was 3.5 months old, she had fever on and off, with rashes all over her body. All the routine investigations were normal except the Mantoux test which was strongly positive at 25mm, her ESR was 90mm/hr and her chest X-ray was normal. The patient was started on anti tubercular treatment for 9 months (INH, Rifampicin, Ethambutol and Pyrizinamid). The child was fine for 6 months. Later on (4/6/ 2009), she had continuous fever and pain in the right leg and after a few days, she was unable to stand properly on the right leg, following which she was taken to theChild Health Hospital in Kolkata. MRI and bone biopsy of the right tibia was done.

MRI report of the right leg gave the following differential diagnosis1. Chronic recurrent multifocal osteomyelitis, 2. Multifocal pyogenic/ tubercular osteomyelitis, 3. Infiltrative disease like leukaemia/ histiocytosis.

Bone marrow biopsy showed interlacing trabacule of the lamellar bone with osteoblasts and osteoid material which were embedded in the fibrous stroma. The marrow spaces showed fibrous and scattered haemopoitic cells. No granuloma was seen. There was no morphological evidence of malignancy or infiltrative disorder.

The child was on a course of antibiotics for 2 weeks. Later on, she developed a swelling on the right elbow, for which she and her parents came to Bangalore.

Family history- both the parents were educated and healthy. None of the family members were suffering from tuberculosis. Her siblings were healthy. Natal history- healthy female child weighing 4.2 kg, delivered by caesarean section. Immunization –BCG scar was seen, DPT and OPV was received. The child had normal milestones.

Her head to toe examination was normal, except for a POP cast over her right leg and a swelling over her right elbow. There was no organomegaly. Her systemic examination was normal.

Investigations which were done-FNAC from the right elbow swelling yielded 1.5 ml of purulent material which showed cellular deposits, large number of neutrophils, degenerated cells, few lymphocytes and histiocytes.There was minimum necrotic debris in the background. No granuloma or epitheloid cells were seen.

The material was AFB positive- it was reported as -tubercular abscess.

The sputum AFB was negative, the liver function tests were normal,

the serum electrolytes were normal and the routine urine analysis was not significant.

All the haematological parameters were within the normal range except, haemoglobin which was 6.8gm/dl and ESR which was 96mm/hr.

The tests for HIV were negative, C-reactive protein – was .92mg/dl (normal-<0.75mg/dl), the abdomino- pelvic scan was normal, the CD4 count was 1065, the CD8 count was 587 and the ratio was 2.7:3.

Chest X-ray (Table/Fig 1) showed –right mid zone perihilar patchy consolidation - ? Pneumonia/ pulmonary Koch’s, X-ray (Table/Fig 2) of the right elbow showed-Soft tissue swelling in the posterior aspect of the upper forearm. Upper end of the ulna showed mixed lytic and sclerotic lesions with periosteal multiple layers of new bone formation -? osteomyelitis, ?neoplastic (Ewing’s). X-rays (Table/Fig 3) of the right leg and knee-1. Lytic lesion with surrounding sclerosis at the metadiaphysis junction of the lower end of the femur. 2. Large lytic lesion in the upper shaft of the tibia with minimal periosteal new bone formation.

Microbiology-Aspiration pus was sent for culture and sensitivityit yielded no aerobic bacterial growth. Acid fast bacilli were present. On L J medium, culture growth was seen after 3 weeks and the niacin test was positive. The aspirate was sent for genotyping to a diagnostic laboratory in Bangalore. The genotyping test was done for the rpo gene, the kat gene, the inh gene, the gyr gene, the rrs gene and the emb gene- the report indicated that the organism which was isolated was Mycobacterium tuberculosis which was resistant to isoniazid (INH), rifampicin and aminoglycosides/ cyclopeptide and sensitive to fluoroquinolones and Ethambutol.

On the basis of these reports, the child was again started on the first line anti tubercular drugs.

The child was taken back to its native place- CMRI, Kolkata. There, she was started on a cocktail of the second line of antitubercular drugs - ethambutol, ciprofloxacin, ofloxacin, ethionamide and pyrazinamide. The lesion healed by one month. The child is on medication and is doing well. The father gave this information.


Though pulmonary TB is the common mode of presentation, MDRTB is usually seen in the already treated cases. Here, we are presenting a case with involvement of the skeletal system, extensively than any other system, with involvement of the long bones of both the upper and the lower limbs on the right side. Tuberculosis of the skeleton comprises 10%-15% of all the extra pulmonary tuberculosis cases (2),(3),(4). Goldblatt and Cremin (5) studied a series of 271 patients with skeletal tuberculosis, who were within 10 years of age and found that six (2.2%) patients had involvement of the long bones without involvement of the joint space. Rasool (6), in his study on 42 children with tubercular osteomyelitis, found an incidence of 20% with associated chest involvement.

In this case with a past history of tuberculosis, TB should havebeen the first in the list of the differential diagnosis. After the anti TB treatment, the child developed a swelling in the elbow, which meant dissemination in a patient who was failing on the treatment. In this case, drug resistance should have been suspected and MDR-TB should have been the diagnosis (7). After susceptibility testing, the second line of the anti TB drugs should have been the choice of therapy. According to the WHO (18th march 2010), it had been estimated that 440000 people had MDR-TB and that one third of them died, out of which 50% of the cases occurred in India and China (8). The failure rates, even after complete treatment with cat1 and cat 2, are 2% and 6% respectively (9).

Sushil Jain from Hinduja hospital examined 3904 lab samples and found that 1274 were positive for MTB. Of these, 32% were MDRTB, out of which 8% were XDR-TB. TB can affect many sites in the body, but the common location is the lungs (10).

The treatment of a patient with MDRTB is a daunting challenge. INH and rifampicin are the most potent anti tubercular drugs, but by definition, they are ineffective in MDRTB and the second line of drugs are less efficacious, more toxic and more costly (11). In a patient who is failing on the treatment, drug resistance must be considered. The drug susceptibility tests should include all the available second line drugs to guide the therapy. Though high mortality and morbidity are associated with MDRTB and XDRTB, they remain as treatable diseases, as has been recently reported in the literature (12),(13).

Genotyping detects the resistance to the antiTB drugs. It was found to have high specificity and a positive predictive value (14). This case highlights the potential problem of MDRTB to XDRTB. The rapid identification of drug susceptibility is virtually important inendemic countries where MDRTB and XDRTB can exist.

Key Message

Tuberculosis in a child of three months indicates the burden of endemicity in our country. Tubercular osteomyelitis comprises only 10-15% of the extrapulmonary tuberculosis cases. MDR-TB is no longer a rarity and always has to be looked for and to be diagnosed early to prevent its transmission.


Weekly Epidemiological Record (WER)...19 March 2010; 85 (12): 109– 116, from www.
Martin M, ed. Tuberculosis of the Bones and Joints. New York, NY: Springer-Verlag; 1988.
Vohra R, Kang HS, Dogra S, Saggar RR, Sharma R. Tuberculous osteomyelitis. J Bone Joint Surg Br. 1997; 79: 562-66.
Wang MN, Chen WM, Lee KS, Chin LS, Lo WH. Tuberculous osteomyelitis in young children. J Pediatr Orthop. 1999;19: 151-55.
Goldblatt M, Cremin BJ. Osteoarticular tuberculosis: its presentation in coloured races. Clin Radiol. 1978;29:669-77.
Rasool MN. Osseous manifestations of tuberculosis in children. J Pediatr Orthop. 2001;21:749-55.
World health organization. Guidelines for the programmatic management of drug resistant tuberculosis. Emergency update 2008, Geneva. World health organization, 2008.Available from WWW.Who. Inf/tb/ publication/2008/ programmatic_guidline for Mdrtd/en/india.html.
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American Thoracic Society 2007, May 22nd. Extremely drug resistant TB, A growing problem in India, Science daily. Sushil Jain Retrieved July 25, 2011 from http://WWW. Science daily .com/ release/2007/05/070521162221.htm.
Kenedy B, Lyons O. McLoughlin AM, etal. Rapid communication. Extensively drug resistant tuberculosis. First report of a case in Ireland. Eurosurveillance July 2008; 13(30): 24..
Mitnick CD, Shin SS, Senng KT, et al. Comprehensive treatment of extensively drug resistant tuberculosis. N.Engl J Med 2008;
Keshavjee S, Gelmanova I, Farmer PE, et al. Treatment of extensively drug resistant tuberculosis in Tomsk, Russia- a retrospective cohort study. Lancet.2008; 372: 1403-09.
Hugen MNT, Tiemersma EW, Lan NTN, et al. Validation of the genotype, MTBDR plus the assay for the diagnosis of multidrug

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