Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018




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Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
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On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
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Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




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Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




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Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




Dr. Arundhathi. S
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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help ones reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journalsNo manuscriptsNo authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Case report
Year : 2012 | Month : May | Volume : 6 | Issue : 3 | Page : 478 - 479

Extensive Idiopathic Scrotal Calcinosis: A Case Report

Vijay D. Dombale, S. I. Basarkod, H.B. Kotabagi, Unaiza Farheen

1. Department of Pathology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India. 2. Department of Surgery, S. Nijalingappa Medical College, Bagalkot, Karnataka, India. 3. Department of Pathology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India. 4. Department of Pathology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

Correspondence Address :
Vijay.D.Dombale
Professor and HOD, Department of Pathology,
S.N.Medical college, Bagalkot-587101, Karnataka, India.
Ph: 09480598017
Mail: drvijay@gmail.com, unaiza85f@rediffmail.com

Abstract

A 54-year-old male diabetic presented with multiple swellings in the scrotal region with a duration of 15 years, which was initially peanut sized and painless and which gradually progressed to 1-1.5 cm in diameter and more than 100 in number. His haematological and biochemical parameters were within normal limits. Fine needle aspiration of the nodule revealed hypocellular smears with a pale pink to bluish coloured granular material in the background. On microscopy, the sections showed calcified nodules and masses with a peripheral giant cell reaction within the dermis and the subcutaneous tissue, which were positive for the Von Kossa stain. It was reported as Idiopathic calcinosis Cutis – Scrotum. Herewith, we are presenting a rare case of extensive idiopathic scrotal calcinosis.

Keywords

Scrotal calcinosis, Idiopathic calcinosis cutis, Calcinosis, Cutaneous calcinosis

Introduction
Idiopathic scrotal calcinosis ( also known as “Idiopathic calcified nodules of the scrotum”) is a cutaneous condition which is characterized by calcification of the skin, resulting from the deposition of calcium and phosphorus, which occurs on the scrotum (1). The main dispute in the pathogenesis of this condition is whether it is a dystrophic calcification of the pre-existing structures like epidermal cyst, etc. or whether it is truly idiopathic (2),(3).

Case Report

A 54-year-old male diabetic patient presented with a history of multiple swellings in the scrotal region with a duration of 15 years. The patient was on oral hypoglycaemic agents. The nodules were initially peanut-sized and painless, but they gradually progressed to 1-1.5 cm in diameter. There were approximately 220 nodules. They were tender, without any discharging sinuses. The skin which overlay the nodules was fixed.

Investi gatiations
1. Complete blood picture - within normal limits
2. Serum and urinary calcium and phosphorus – normal
3. Blood sugar (Fasting and Post-prandial) – within normal limits
4. Fine needle aspiration- It was difficult to penetrate the nodule. The needle entered with a gritty sensation and the granular material was aspirated. The resultant smear was hypocellular with refractile irregular crystals in groups and they were dispersed singly in a haemorrhagic background. “En Bloc excision of the lesion was done and it was sent for a histopathological examination.” The patient’s sugar levels were well controlled with insulin at the time of the surgery. There were no local or post-operative complications. Grossly, the lesion was a grey-brown cauliflower-like skin covered mass which measured 10×8×5 cm. The external surface showed multiple (a total of 220) nodules which varied in size from 5–20 mm. Microscopy showed nodules in the dermis with an amorphous basophilic material which was surrounded by a foreign body type of giant cell reaction. The rest of the tissue showed focal round cell infiltration. Special staining (Von Kossa’s ) showed a dark black granular material within the nodules.

Diagnosis
A diagnosis of idiopathic Calcinosis Cutis- Scrotum was made. No recurrence was observed in a follow-up period of 6-8 months.

Discussion

Idiopathic Scrotal Calcinosis ( ISC ) was first described by Lewinsky in 1883 as a subtype of calcinosis cutis (2). It is a rare and benign condition, the exact incidence of which is not known. The deposition of calcium in the skin, sub-cutaneous tissue, muscles and the visceral organs is known as calcinosis. This condition commonly occurs in the skin, where it is known as calcinosis cutis or cutaneous calcification. Calcinosis cutis has been divided into 4 major types on the basis of the original causes of the symptoms, as dystrophic, metastatic, idiopathic and iatrogenic (4). Idiopathic calcinosis cutis occurs in the absence of a tissue injury or a systemic metabolic effect. No causative factor has been identifiable and the calcification is most commonly localized to one general area. Idiopathic calcification of the normal skin has been described in the scrotum, penis, vulva and the breast (5).

Many authors have proposed that scrotal calcinosis represents dystrophic calcification of the pre-existing structures including the epidermal cysts, eccrine duct milia, eccrine epithelial cysts and the degenerated dartoic muscle. In the dystrophic form, the calcium and the phosphorus levels are normal, and there is a local favouring condition that predisposes the calcinosis. It may be observed in connective tissue diseases like scleroderma, dermatomyositis, SLE and secondary to trauma and inflammation (2). In our case, there was no history of connective tissue disease and trauma and the patient’s serum values of calcium and phosphorus were within normal limits. No existing inflammation or epithelial lining was found around the calcified nodules microscopically. Hence, the diagnosis of idiopathic scrotal calcinosis was made.

The result of the surgical excision was satisfactory and there was no recurrence in a follow-up period of 6 months. The uniqueness of this case lies in the extensive involvement of the scrotum with 220 nodules, the latest case which has been reported having 51 nodules as was reported by Song et al. (6).

References

1.
http:// en.wikipedia.org/wiki/idiopathic_Scrotal_calcinosis
2.
Kelten EC, Akbulut M, Colakoglu N, Bayramoglu H, Duzcan SE. Scrotal Calcinosis: is it idiopathic or dystrophic? Aegean Pathology Journal. 2005; 2:4-7.
3.
Hicheri J, Badri T, Fazaa B, Zermani R, Kourda N, Jilani SB, et al. Scrotal Calcinosis: Pathogenesis and case report. Acta Dermatoven APA. 2005; 4(2):53-56.
4.
http://www.dermnetnz.org/systemic/calcinosis.html
5.
Kanishwar VS, Waghmare RS, Puranik GV. Calcinosis Cutis in the CREST Syndrome. Bombay Hospital Journal. 2010; 52(1):108-110.
6.
Song DH, Lee KH, Kang WH. Idiopathic calcinosis of the scrotum: histopathologic observations of fifty-one nodules. Journal of the American Academy of Dermatology. 1990 Jul;23(1):150-51.

DOI and Others

DOI: JCDR/2012/3945:2071

Financial OR OTHER COMPETING INTERESTS:
None.


Date of Submission: Aug 25, 2011
Date of Peer Review: Nov 03, 2012
Date of Acceptance: Jan 12, 2012
Date of Publishing: May 01, 2012

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