Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018




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Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
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Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018




Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
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Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
Lucknow
On Sep 2018




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Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata




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Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
Muzaffarnagar.
On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Case report
Year : 2012 | Month : May | Volume : 6 | Issue : 3 | Page : 483 - 484

Venous Hemangioma of the Breast: Report of an Unusual Case

Leena, Suma

1. Corresponding Author, 2. Assistant Professor, Department of Pathology NAME OF DEPARTMENT(S)/INSTITUTION(S) TO WHICH THE WORK IS ATTRIBUTED: Department of Pathology, M V J Medical College and Research Hospital, Hoskote, Bangalore, Karnataka, India.

Correspondence Address :
Dr. Leena
Assistant Professor,
No 56/74, 4th Main, Nehru Street,
Behind Tin Factory, Udaynagar, Bangalore- 560016
Phone: 9902766378
E-mail: drleenapriye@yahoo.co.in

Abstract

Vascular tumours of the breast are uncommon and they include angiosarcomas and hemangiomas. Hemangiomas are rare and angiosarcomas are more common than hemangiomas of the breast. Here, we are reporting a case of a 19-year old girl who presented with a non tender palpable lump in the left breast since 15 days. Mammography and FNAC were inconclusive and the diagnosis was established on the basis of histopathology. This case was reported to highlight that a single diagnostic modality may not be sufficient to diagnose a case of hemangioma. Though it is a benign lesion, a histopathological evaluation is necessary for its accurate diagnosis and to rule out underlying malignancy, if any.

Keywords

Hemangioma , Breast , Benign tumour, Histopathology

Introduction
Vascular tumours of the breast are rare and most of them can be classified as angiosarcomas or hemangiomas (1). Hemangiomas are benign tumours that are rarely seen in the breast, although they have been found incidentally on the microscopy of biopsy material which had been sent for other indications. Breast hemangiomas are reported to be found in ~1.2% of all the mastectomy specimens and 11% of all the post-mortem specimens. The hemangiomas that occur within the breast are most commonly of the cavernous type. While the lesions are most often superficial within the breast tissue, there is no recognised predilection towards any particular location within the breast. On mammography, the findings are non-specific and they include a normal mammogram or a sonographic finding of a well circumscribed hypo echoic or hyper echoic mass with or without calcification (2). Complete excision and examination is required for the diagnosis of any benign vascular lesion in the breast.

Case Report

A 19-year old girl visited the surgery OPD with complaints of a non tender palpable lump in the left breast since 15 days. She was nulliparous and gave no other history of trauma, nipple discharge, fever or any prior breast disease. On examination, a single, well defined, mobile, firm mass, which was 3 cm in diameter, was found in the upper outer quadrant of the left breast. A clinical diagnosis of lipoma was offered. Mammography showed a well circumscribed isodense mass in the left breast. Repeated FNAC yielded only blood. The possibility of a vascular lesion was suggested and a complete excision of the lump was done. We received a globular mass cut section, which showed red brown areas. Haematoxylin and eosin sections showed large cavernous vascular channels of smooth muscles which were filled with blood and focal areas of adipocytes, which were suggestive of a subcutaneous hemangioma (Table/Fig 1). There was no recurrence after 6 months of follow up.

Discussion

Hemangiomas are benign vascular tumours that are usually identified incidently during the histological examination of specimens of lumpectomy or mastectomy (3). They occur in patients of the age group of 18-82 years (4). The mammographic appearance of hemangiomas is as macrolobulated lesions and they may contain calcification. Our case did not show any calcification and the findings were nonspecific. Most often, they are located superficially, either subdermally or in the subcutaneous tissue. Rarely may hemangioma be intraparenchymal (5). Oval lobulated lesions with poorly defined borders have been reported (6). However, because of their typical pattern of enhancement, magnetic resonance imaging may be useful in the diagnosis of breast hemangiomas (7). The imaging features appear to be inconclusive for the diagnosis of most of the hemangiomas (6). Fine needle aspiration cytology too is inconclusive and a complete excision is required for the diagnosis. They are grossly described as well circumscribed masses which are red brown and spongy. Most of the hemangiomas are well circumscribed grossly, but microscopically, they blend well with the breast parenchyma (8). Microscopically, there are two common types of hemangiomas: capillary and cavernous. Most of these have vascular channels which are separated by fibrous septa, with extensive fibrosis and sometimes with phleboliths (3). Capillary hemangiomas are composed of capillary sized blood vessels and cavernous hemangiomas have large vascular channels. Cavernous hemangiomas are more common than the capillary hemangiomas (4). Hemangiomas are sub-divided into four types: perilobular, parenchymal, non parenchymal or subcutaneous and venous. Perilobular hemangiomas occur in the extralobular stroma in the form of microscopic lesions. In parenchymal hemangiomas, the individual vessel varies in size from capillary to cavernous. Venous hemangiomas form large cavernous vascular channels, with disorderly vascular proliferation. Sub-cutaneous hemangiomas are located superficial to the anterior pectoral fascia in the sub-cutaneous fat (9). Histologically, hemangiomas should be differentiated from pseudoangiomatous stromal hyperplasia (PASH) which do not have a true endothelial lining and do not show luminal RBCs (4). Furthermore, venous hemangiomas of the breast are rarer, with only few cases being reported (9). Hemangiomas, although they are not known to be precursors of angiosarcomas, follow up imaging techniques are recommended for their diagnosis and wide local excision is necessary to rule out the possibility of underlying angiosarcoma (10). In conclusion, venous hemangioma of the breast is uncommon and we should be aware of this entity. Imaging findings and fine needle aspiration cytology are inconclusive in most of the cases and this may lead to a diagnostic dilemma. Histopathology is essential for a definitive diagnosis.

References

1.
Dener C, Sengul N, Tez S, Caydere M. Hemangiomas of the breast. Eur J Surg 2000;166:977-79.
2.
Hoda SA, Cranor ML, Rosen PP. Hemangiomas of the breast with atypical histologic features: further analysis of the histological subtypes confirm their benign character. Am J Surg Pathol 1992; 16:553-60.
3.
Kim SM, Kim HH, et al . Cavernous hemangioma of the breast. British Journal of Radiology. 2006; 79: e177-e280.
4.
Kavatra V, Lakshmikantha A, Dingra KK, Gupta P, Kurana N . A rare coexistence of concurrent breast hemangioma with fibrodenoma- a case report. Cases Journal 2009, 2:7005
5.
Siewert B, Jacobs T, Baum JK. Sonographic evaluation of subcutaneous hemangioma of the breast. AJR 2002; 178:1025-27
6.
Sung HK, Jae HL, Kim DC, Song BJ. Sub-cutaneous venous hemangioma of the breast. J Ultrasound Med 2007; 26:1097-100
7.
Flis M, Michelle M, Akbar N . An unusual case of an enlarging mass on a screening mammogram. A case report and review of radiology and current literature. The Breast 2003; 220-22.
8.
Rosen PP, Rosen’s Breast Pathology, 2nd edn. Lippincott Williams and Wilkins 2001; 789-97.
9.
Rosen PP, Jozefczyk MA, Boram LH. Vascular tumors of the breast IV: the venous hemangiomas. Am J Surg Pathol 1985;9:659-65.
10.
Rosen PP, Jozefczyk MA, Boram LH. Vascular tumors of the breast V : non parenchymal hemangiomas of the mammary subcutaneous tissue. Am J Surg Pathol 1985; 9:659-65.

Tables and Figures
[Table / Fig - 1]
DOI and Others

DOI: JCDR/2012/3613:1984

Financial OR OTHER COMPETING INTERESTS:
None.

Date of Submission: Sep 29, 2011
Date of Peer Review: Nov 03, 2011
Date of Acceptance: Dec 23, 2011
Date of Publishing: May 01, 2012

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