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Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals�No manuscripts�No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."
Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011
Dr. Shankar P.R.
"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."
Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011 Anuradha
Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.
Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020
Experimental Research
Full Version
Analgesic Effects of Dashamula, an Ayurvedic Preparation, versus Diclofenac Sodium in Animal Models
Correspondence Address :
Dr. Mushtaq Ahmad
Mahatma Gandhi Medical College
Sitapura, Jaipur-302022.
Phone: +91-9460983755
E-mail: marumush@gmail.com
Background and Objectives:
Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs which are most commonly used to control pain. But the adverse effects that they produce are the limitations in their use. Many medicinal preparations are commonly used for the treatment of pain in alternative medicine. One such commonly used Ayurvedic preparation is Dashamula, a combination of the roots of ten plants, a standard Ayurvedic remedy for the treatment of pain. However, studies which have evaluated its role as an analgesic in comparison with NSAIDs are not available.
Materials and Methods:
Healthy albino mice of either sex, which weighed 30–50 g, were used for the anti-nociceptive test: the writhing test. The animals (n=24) were allocated to four groups (GI, GII, GIII and GIV) of six mice each, which received either saline as a control or a low dose of Dashamula or a high dose of Dashamula or Diclofenac sodium. The statistical analysis was done by using the Student’s ‘t’-test. A probability value of less than 0.05 (P< 0.05) was considered to be statistically significant.
Results:
A highly significant (p<0.001) reduction in the number of writhes was noted in the groups which were treated with high dose Dashamula and Diclofenac sodium and there was a significant (p<0.01) difference in the number of writhes in the group which was treated with low dose Dashamula as compared to that in the controls. Although the degree of analgesia was greater in the group which was treated with high dose Dashamula as compared to the group which was treated with Diclofenac sodium, the difference was not statistically significant (p>0.05). The analgesic action of high dose Dashamula and Diclofenac sodium started within 30 min, with a complete abolition of the writhes from 90 min onwards. The time course of action in the group which was treated with high dose Dashamula was quicker and faster than in the Diclofenac sodium group, however, this difference was statistically insignificant (p>0.05).
Conclusions:
The analgesic activity of Dashamula, both in terms of the degree of analgesia and the time course of action was comparable to that of Diclofenac sodium, a standard NSAID. Hence, Dashamula could be a possible alternative to NSAIDs. Further studies, experimental and clinical, are needed to explore this possibility.
Analgesic effect, Dashamula, Diclofenac sodium, Writhing test, NSAIDs
INTRODUCTION
Non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay of treatment for a variety of painful conditions (1). Various NSAIDs and their fixed dose combinations are routinely employed in the clinical practice to control pain. Though these drugs are effective in controlling pain, their wide range of adverse effects are the biggest limitations in their use. Because of the side effect profile of NSAIDs, the patients are inclined to choose an alternative system of treatment. Many studies have compared the alternative medicinal preparations and the classical nonsteroidal anti-inflammatory agents for their analgesic effect in clinical and experimental settings (2),(3),(4). A number of alternative medicinal preparations are commonly employed in Ayurveda to control pain. Dashamula, a combination of the roots of ten plants, is a standard Ayurvedic remedy for the treatment of pain (5),(6). It is an age old herbal preparation which is commonly used by the Vaidyas (Ayurvedic practitioners) in their practice, to reduce pain. However, studies which have evaluated its role in controlling pain both in experimental and clinical settings, are not available. Original Article Pharmacology Section Hence, the present study was planned to evaluate the analgesic efficacy of Dashamula, and to compare it with a standard NSAID, Diclofenac sodium, in animal models.
Animals
Healthy albino mice of either sex (6 to 7 weeks old), which weighed 30–50 g, were used for the anti-nociceptive test: the writhing test. The animals were housed within the departmental animal house and the room temperature was maintained at 27 degree Celsius. The animals were fed with the standard pellet diet (Lipton India laboratories, Bangalore) and water ad libitum and they were starved overnight before the day of the experiment. The study protocol was approved by the Institutional Animal Ethics Committee.
Investigational Drugs and Dosage Preparation
A tablet formulation of Diclofenac sodium, 50 mg, (Torrent Labs Pvt. Ltd- “Torrent House” Near Dinesh Hall, off Asram Road, Ahmedabad) was purchased from the hospital pharmacy counter and Dashamula was purchased from a standard Ayurvedic shop (Mankarika Aushadhalaya, 1015, Sadasivepeth, Pune-30). Dashamula is a collection of ten ingredients viz. Aegle marmelos (Bilva), Premnain tegrifolia (Agnimantha), Oroxylum indicum (Shyonaka), Stereospermum suaveolens (Patla), Gmelina arborea (Kashmiri), Desmodium indicum (Shaliparni), Urari alagopoides (Prishniparni), Solanum indicum (Brahati), Solanum xanthocarpum (Kantkari) and Tribulus terrestris (Gokshura). Each ingredient was procured separately in coarse powder form. The identification of the first three ingredients of Dashamula viz. Aegle marmelos (Bilva), Premnain tegrifolia (Agnimantha) and Oroxylum indicum (Shyonaka) was done at Poona College of Pharmacy, Pune, and the rest of the ingredients were identified at Bharti Vidyapeeth Ayurvedic College, Pune. The appropriate body weight adjusted doses of the test drugs were extrapolated from the doses to be 0.28 ml and 0.41 ml/20 gm mice as low and high doses for Dashamula and 0.39 mg/20 gm mice for Diclofenac sodium were used (7). The formulation for Diclofenac sodium was made as a 2% w/v uniformly mixed suspension which was prepared in gum acacia. The formulations were fed to the animals through a 2–3 cm polythene tubing which was sleeved on an 18–20 gauge blunted hypodermic needle. Saline 0.28ml/ 20gm mice was used concomitantly as a control in all the groups.
Method of the extraction of Dashamula (8) One gram of each ingredient of Dashamula was taken and mixed properly in a grinder by adding 160 ml of water to make 10 gm/160 ml of the Dashamula mixture. The mixture which was so prepared was boiled till it was reduced to 1/8th of its initial volume i.e. 20ml and it was filtered. The decoction which was hence produced was tested for its antinociceptive activity in mice. A fresh decoction of Dashamula was made every time for use in the experimental animal groups.
Experimental Protocol
The animals (n=24) were allocated to four groups (GI, GII, GIII and GIV) of six mice each. Depending upon the treatment design, each group received saline as a control (GIc) and Dashamula low dose (GIIdld), Dashamula high dose (GIIIdhd) and Diclofenac Sodium (GIVds) as the test drugs respectively.
Assessment of the Analgesic Activity by Acetic Acid-Induced Writhing in Mice
(9),(10) Calculated, weight adjusted, doses of the test drugs, i.e. Dashamula low dose 0.28 ml/20 gm, Dashamula high dose 0.41 ml/20 gm, Diclofenac 0.39 mg/20 gm and saline 0.28 ml/20 gm mice as the control were given p.o. to the mice 2 hours prior to their anti-nociceptive tests. The anti-nociceptive effect was tested by counting the number of writhes, by calculating the average number of writhes which were recorded every 30 min up to 240 min for each test group after the injection of 1% (1 ml/100 g) acetic acid i.p (11). The anti-nociceptive activity was calculated as the percent maximum possible effect (% MPE)
MEAN ERITHES GLC- MEAN ERITHES TEST
% MPE =________________________________________× 100
Mean writhes GI
Test groups = GIIdld, GIIIdhd, GIVds
Statistical Analysis
The results were expressed as mean ± SEM. The statistical analysis was done by using the Student’s ‘t’-test. A probability value of less than 0.05 (P< 0.05) was considered to be statistically significant.
Degree of Analgesia which was Produced by Dashamula and Diclofenac Sodium
The groups which were treated with Dashamula high dose and Diclofenac sodium showed a highly significant (p<0.001) reduction in the number of writhes and the group which was treated with Dashamula low dose showed a significant difference (p<0.01) as compared to the control (Table/Fig 1). By comparing the degree of analgesia, as indicated by a reduction in the number of writhes, no significant difference was observed between the treatment groups i.e Dld Vs. Dhd and Dld Vs. Ds (p> 0.05). Though the degree of analgesia was greater in a group which was treated with Dashamula high dose as compared to a group treated with Diclofenac sodium, this difference was statistically insignificant (p>0.05).
Time Course of the Analgesic Action of Dashamula and Diclofenac Sodium
The drug treated groups showed a significant difference (p<0.001) in the time course of the analgesic action, as was indicated by the percentage of reduction in the number of writhes after different time intervals as compared to the controls (Table/Fig 2). On studying the time course of action of the test drugs, the analgesic action of Dashamula high dose was found to have started within 30 min (less than 60% reduction in the number of writhes), with the complete abolition of the writhes from 90 min onwards. As against this, Diclofenac sodium showed less than 40% reduction in the number of writhes within 60 min, though the complete abolition of the writhes from 90 min onwards was the same as it was for Dashamula high dose. However, this difference in the time course of action of the drug treatment was statistically insignificant (p<0.05). The time course of analgesic action was also within 30 min in the group which was treated with Dashamula low dose, though the complete abolition of the writhes was observed 120 min onwards.
Many treatment strategies are utilized to alleviate pain in clinical as well as post surgical conditions. Non-steroidal anti-inflammatory drugs (NSAIDs), either alone or in fixed dose combinations, are the drugs which are commonly used for analgesia in modern medicine. As their side effect profile has always been a focus of concern and limitation to their use, many alternative agents have been tried in the clinical practice to alleviate pain as well. One such commonly used Ayurvedic preparation in Ayurveda is Dashamula, a combination of the roots of ten plants, for the treatment of pain and inflammation (5),(6). Apart from its use with other Ayurvedic preparations for the treatment of different conditions, it is commonly used with milk to relieve pain in the Ayurvedic practice (6). Studies which have evaluated its role as an analgesic and have compared it with standard NSAIDs in modern medicine are not available. Hence, this study was undertaken to evaluate the analgesic efficacy of Dashamula and to compare it with Dilofenac sodium in animal models. The comparison was done in terms of the degree of analgesia and the time course of action of the drugs. As far as the degree of analgesia was concerned, all the test groups showed a significant difference in the reduction in the number of writhes after 1% acetic acid injection as compared to the controls (Table/Fig 1). A comparatively greater degree of analgesia was observed in a group which was treated with Dashamula high dose as compared to a group which was treated with Diclofenac sodium; however, this difference was statistically insignificant (p>0.05). This indicated that the degree of analgesia which was achieved in both the groups which were treated with Dashamula high dose and Diclofenac sodium was comparable. Though studies which have compared the Dashamula preparation with NSAIDs for the evaluation of analgesia are lacking, studies which have evaluated the analgesic effect of either of the active ingredients of Dashamula are available. Studies on Aegle marmelos (Bilva), an active ingredient of Dashamula, have shown significant analgesic properties (12),(13),(14). Oroxylum indicum (Shyonaka) and Stereospermum Suaveolens (Patla), the other active ingredients of Dashamula, have also shown significant analgesia (15),(16),(17). Hence, the results of our study are not only in accordance to the findings of these studies in stating the analgesic effect of Dashamula, but they also support the Ayurvedic texts and other studies which claim Dashamula as a remedy for pain (6),(18),(19). On assessing the time course of action of the test drugs, all the treatment groups were found to show a significant difference as compared to the controls as well (Table/Fig 2). The reduction in the number of writhes, though it started within 30 min with complete abolition in 90 minutes in the treatment groups which were treated with Dashamula high dose and Diclofenac sodium, the percentage in the reduction in the number of writhes was quicker and greater in the group which was treated with Dashamula high dose. However, this difference was not statistically significant (Table/Fig 2). This also indicated that the onset and the duration of the analgesic action of Dashamula high dose and Diclofenac sodium in both the groups were the same. Therefore, on assessing the overall results in terms of the degree of analgesia and the time of the course of action, both the Dashamula high dose and Diclofenac were found to be superimposed on each other. Hence, this study revealed Dashamula’s activity both in terms of the degree of analgesia and the time course of action to be comparable to Diclofenac sodium. Thus, Dashamula can be a possible alternative to the non-steroidal anti-inflammatory agents (NSAIDs).
DOI: JCDR/20123768:1944
Financial OR OTHER COMPETING INTERESTS:
None.
Date of Submission: Sep 15, 2011
Date of Peer Review: Nov 29, 2011
Date of Acceptance: Dec 22, 2011
Date of Publishing: May 01, 2012
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