Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Dr Bhanu K Bhakhri

"The Journal of Clinical and Diagnostic Research (JCDR) has been in operation since almost a decade. It has contributed a huge number of peer reviewed articles, across a spectrum of medical disciplines, to the medical literature.
Its wide based indexing and open access publications attracts many authors as well as readers
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Faculty, Pediatric Medicine
Super Speciality Paediatric Hospital and Post Graduate Teaching Institute, Noida
On Sep 2018

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On Sep 2018

Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."

Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
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Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018

Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."

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Professor and Head
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Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018

Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
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I wish JCDR a great success and I hope that journal will soar higher with the passing time."

Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
On Sep 2018

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Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata

Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
On Aug 2018

Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".

Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
On Aug 2018

Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".

Dr. Mamta Gupta
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018

Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.

Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."

Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Case report
Year : 2012 | Month : April | Volume : 6 | Issue : 2 | Page : 299 - 300

Endophthalmitis Due to Corynebacterium Jeikeium: A Case Report

Asima Banu, Nagraj E.R., Vidyadevi M.

1. Associate Professor Dept of Microbiology Bangalore Medical College and Research Institute Bangalore, India. 2. Professor Department of Microbiology Siddhartha Medical College Tumkur, India. 3. Assistant professor Department of Ophthalmology Bowring and Lady Curzon Hospital Bangalore, India.

Correspondence Address :
Dr Asima Banu
Department of Microbiology
Bowring and Lady Curzon Hospital
Shivajinagar, Bangalore - 560001
Phone: 9845720258


Endophthalmitis is a grave complication of ocular trauma. We report here a case of acute post-traumatic endophthalmitis following a penetrating injury caused by an opportunistic organism, Corynebacterium jeikeium. The patient was treated with intra-vitreal antibiotics like ceftazidime and vancomycin to control the infection.


Endophthalmitis, Corynebacterium, Ocular trauma

We report here a case of endophthalmitis caused by Corynebacterium jeikeium after accidental trauma. This is the first of such a case to the best of our knowledge and adds this species to the list of unusual pathogens complicating ocular infections. Ophthalmologists treating patients with endophthalmitis should be aware of this bacterial genus as a potential cause of invasive ocular infections.

Case Report

A 7-year-old female sustained a penetrating injury to the right eye with a iron rod,while playing outdoors. Patient reported to a regional institute of Ophthalmology within 12 hours after trauma with redness and watering of the right eye and had been treated with topical eye drops by a local doctor. On examination, the patient had lid oedema, conjunctival as well as ciliary congestion and central full thickness corneal tear, as shown in [Table/Fig-2] with iris prolapse with shallow anterior chamber. The view of lens and posterior segment was hazy, vision was counting finger 1 metre.

Immediately, patients conjuctival swab was sent for culture and sensitivity which yielded no growth of micro-organisms. Patient was admitted and repair of corneal tear with iris abscission was done under local anaesthesia. Intravenous (I.V) antibiotic amoxycillin + clavulanic acid (50-100 mg/Kg/day) three times a day with I.V Metrogyl (10mg/Kg/dose) three times a day was started. Next day patient was followed up, there was diffuse corneal haziness with circumciliary congestion, four corneal sutures were visible. Other details of anterior chamber could not be made out. The vision had dropped to no perception of light. Patient was started on topical fortified cefazolin 5% with fortified tobramycin 1.4% along with homatropine 2% eye drops three times a day, hypersol 6% (hypertonic sodium chloride 6% w/w) eye ointment, flurbiprofen (0.3%) eye drops four times a day and tablet serratiopeptidase 10mg twice a day. B-scan was performed which revealed multiple dot like opacities in the vitreous which disappeared at low gain.

So the presumptive diagnosis of endophthalmitis was made and 0.3ml vitreous tapped for Gram’s stain, potassium hydroxide (KOH) mount and bacterial and fungal culture & sensitivity was sent toSectionthe Microbiology laboratory. Concurrent intravitreal injection of ceftazidime 2.25mg/0.1ml of saline and vancomycin 1 mg/0.1 ml of saline was given.

Patient was followed up daily, systemic antibiotics were continued for 5 days and the same topical antibiotics were continued. Her vision had improved to perception of light by the 5th day. Patient was asked to follow up on Day 3, 7, 14, 21 and then monthly. After 2 months, patient’s vision had not improved and patient had developed complicated cataract with other posterior fundus details not made out. Patient was sent for B scan again but was lost to follow up.

The Vitreous tap was received at the Department of Microbiology. The Gram stain of the specimen showed plenty of pus cells with short Gram positive rods. The KOH mount was negative for fungal elements. The sample was processed by inoculating onto 5% sheep blood agar, brain heart infusion broth and Robertson’s cooked meat media and incubated at 370 C. For fungal culture the sample was inoculated onto Sabouraud’s dextrose agar. After overnight incubation, blood agar revealed growth of pearly white colonies that were non-haemolytic on blood agar. Gram’s stain of the colonies revealed short, Gram positive bacilli. Albert’s stain revealed bacilli in palisade arrangement without metachromatic granules. Conventional tests revealed the strain that was positive for catalase, negative for oxidase, non motile, fermented glucose and produced black colonies on potassium tellurite agar. Anaerobic culture yielded no growth after 10 days. Fungal culture yielded no growth after 4 weeks. Presumptive identification of Corynebacterium spp was made and the isolate was further identified by commercially available API Coryne system (version 2.0; bioMe´rieux, Marcy-l’Etoile, France) which identified the strain as Corynebacterium jeikeium. The isolate was tested for antibiotic sensitivity on Muller Hinton agar by Kirby Bauer disc diffusion technique using standard methods. The antibiotic discs used were Amikacin (30mcg), Cephalexin (30mcg), Ciprofloxacin(01mcg), Tobramycin (10mcg), Ampicillin (10mcg), Vancomycin (30mcg). The strain was resistant to ampicillin, ciprofloxacin and cephalexin.


Infectious endophthalmitis is a potentially devastating complication of penetrating ocular injuries. Traumatic endophthalmitis due to unusual organismsis not uncommon and usually causes a poor final visual outcome, especially with virulent organisms (1). C. jeikeium is considered part of the normal flora of the skin, particularly of inpatients and can also be recovered from the inanimate hospital environment. C. jeikeium, formerly characterized as diphtheroids belonging to CDC group JK, currently belongs to lipophilic Corynebacterium. They were known to be associated although not exclusively, with immunocompromised hosts with malignancies, in-place medical devices, prolonged hospital stays, breaks in integument, and therapy with broad spectrum antibiotics (2).

Clinical manifestations of C. jeikeium infections include nosocomial septicemia, bacteremia, pulmonary infiltrates in patients with bone marrow disorders, cavitating pneumonia in a patient with chronic obstructive pulmonary disease, skin rashes, septic cutaneous emboli, meningitis, and soft tissue infections, particularly among granulocytopenic patients (3), (4). C. jeikeium isolates are pleomorphic, occasionally club shaped, gram-positive rods, arranged in V forms or palisades. After 24 h of growth on Sheep Blood Agar at 37oC, colonies are nonhemolytic, small (0.5 to 1 mm), entire, low convex, and pearly-white. Theorganism is a strict aerobe, with no growth occurring anaerobically. The CDC identification scheme identifies catalase-positive, oxidasenegative, penicillin-resistant (usually), lipid-requiring coryneforms that are nitrate and urea negative but able to ferment glucose, usually galactose, and sometimes maltose, as group JK. These strains are otherwise biochemically inert (5).

C. jeikeium strains are often multi-resistant to antibiotics but are susceptible to glycopeptides and pristinamycin, with variable susceptibility to erythromycin, tetracycline, rifampin, and quinolones. Resistance to antibiotics is thought to be chromosomal rather than plasmid associated. In fact, multiple resistance has been used as a screening test for this species (6). To conclude, multidrug resistant strains of commensal organisms can also lead to fulminant endophthalmitis with dire consequences as seen in our case. With meticulous microbiological evaluation including drug sensitivity and timely intervention with appropriate medication results appear encouraging.


Lieb, DF, Scott, IU, Flynn, HW, Jr, Miller, D & Feuer, WJ. Open globe injuries with positive intraocular cultures: factors influencing final visual acuity outcomes. Ophthalmology. 2003; 110:1560–66.
Funke G, von Graevenitz A, Clarridge JE, Bernard KA. Clinical Microbiology of Coryneform Bacteria. Clinical Microbiology Reviews. 1997; 10(1): 125–59.
Coyle MB, Lipsky BA. Coryneform Bacteria in Infectious Diseases: Clinical and Laboratory Aspects. Clinical Microbiology Reviews. 1990; 3(3): 227-46.
Connell PP, O’Neill EC, Fabinyi D, Islam FMA, Buttery R, McCombe M et al. Endogenous endophthalmitis:10-year experience at a tertiary referral centre. Eye. 2011;25:66–72.
Riegel P, de Briel D,Prevost G,Jehl F,Monteil H. Genomic Diversity among Corynebacterium jeikeium Strains and Comparison with Biochemical Characteristics and Antimicrobial Susceptibilities. Journal of Clinical Microbiology. 1994; 32(8): 1860-65.
Weiss K, Laverdie`re M, Rivest R. Comparison of Antimicrobial Susceptibilities of Corynebacterium Species by Broth Microdilution and Disk Diffusion Methods. Antimicrobial agents and Chemotherapy. 1996; 40(4):930–33.

DOI and Others

DOI: JCDR/3121:1893


Date Of Submission: Aug 15, 2011
Date Of Peer Review: Dec 26, 2011
Date Of Acceptance: Jan 17, 2012
Date Of Publishing: Apr 15, 2012

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