Clear Cell Atypical Fibroxantoma: A Rare Variant of Atypical Fibroxanthoma and Review of the Literature
Correspondence Address :
Dr. Recep Bedir,
Recep Tayyip Erdogan University of Medical Faculty, Department of Pathology, Rize-53000, Turkey.
Phone: +90 464.2130491; Fax : + 90 464 2170364
E-mail: bedirrecep@gmail.com
Atypical fibroxanthoma (AFX) is a superficial variant of pleomorphic malignant fibrous histiocytoma. Clear cell atypical fibroxanthoma (CCAFXA) is a rare variant of atypical fibroxanthoma. A 74-year-old male patient presented with a rapidly growing nodule on the shoulder, which had appeared over a 5-months period. Lesion was excised by the plastic surgeon. Microscopic examination showed an ulcerated nodule composed of pleomorphic spindled and polygonal cells with clear or vacuolated cytoplasm. The neoplastic cells were stained positively with CD68 and CD10 and were stained negative with S-100, Melan A, muscle-specific actin, or pan-cytokeratin. Final diagnosis was clear cell atypical fibroxanthoma. CCAFXA should be differentiated from other clear-cell neoplasms of the skin. Best of our knowledge only 11 cases CCAFXA of have been reported in published studies till date. Herein, we reported 12th case in literature of CCAFXA and review of the literature.
Skin, Clear cell atypical fibroxanthoma, Immunohistochemistry, Differential diagnosis
DOI: 10.7860/JCDR/2014/8798.4466
Financial OR OTHER COMPETING INTERESTS: None.
Date of Submission: Feb 04, 2014
Date of Peer Review: Mar 24, 2014
Date of Acceptance: Apr 28, 2014
Date of Publishing: Jun 20, 2014
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