Bronze Diabetes
Correspondence Address :
Dr. Rukmini. M.S.,
Associate Professor, Department of Biochemistry, Centre for Basic Sciences,
Kasturba Medical College, Bejai, Mangalore-575004, India.
E-mail: rukmini.shetty@manipal.edu
Thalassemia is a group of disorders characterized by deficient production of the ß-globin sub unit of hemoglobin. The mandatory blood transfusions in patients with thalassemia to maintain adequate erythrocyte levels, leads to iron overload. The prevalence of diabetes in patients with thalassemia varies from 6 to 14%. We here by present a known case of thalassemia major in an 18 year old boy. He was diagnosed with thalassemia before the age of one year and is on regular blood transfusion every two weeks since then. The repeated blood transfusion is one of the common causes for haemochromatosis. Iron overload initially leads to glucose abnormalities such as insulin resistance and hyperinsulinemia, which is followed by impaired secretion of insulin. Diagnosed as a case of bronze diabetes, this patient is on insulin therapy for the last two years. Currently the patient is on iron chelation therapy at Kasturba Medical College Hospital, Mangalore, Karnataka, India.
Serum ferritin, Thalassemia, Type I diabetes
DOI: 10.7860/JCDR/2015/11515.5799
Date of Submission: Oct 08, 2014
Date of Peer Review: Feb 19, 2015
Date of Acceptance: Feb 20, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: None.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com