Effect of Silymarin in the Prevention of Cisplatin Nephrotoxicity, a Clinical Trial StudyCorrespondence Address :
Division of Hematology, Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Background: Reno-protective effect of Silymarin was studied in some studies mainly on rats. In some of these studies, Silymarin was shown to have positive effects on preventing or decreasing severity of Cisplatin nephrotoxicity.
Objective: The aim of this study was to evaluate the protective effect of Silymarin on Cisplatin nephrotoxicity in adult patients with malignancy.
Materials and Methods: In this clinical trial study, 60 patients with malignancy, candidate of Cisplatin treatment were randomly enrolled in two equal groups. In patients of case group, Silymarin tablet 140 mg/bid was administrated seven days before Cisplatin administration together with Cisplatin, and in control group, Cisplatin was prescribed. Blood Urea Nitrogen (BUN) and serum Creatinine (Cr) were checked at the same day and 3 and 7 days after administration of Cisplatin.
Results: Mean age of the patients in case and control groups were 51.1±14.3 y and 51.1±13.7 y respectively (p=0.99). There was no significant difference based on BUN and serum Cr in the beginning of study and three days after administration of Cisplatin in two groups of patients, however, after two weeks, BUN and serum Cr were significantly lower in the case group compared to the control group. Also, in the case group, BUN and serum Cr decreased and in the control group, they increased after two weeks after Cisplatin administration.
Conclusion: This study showed that Silymarin can decrease Cisplatin nephrotoxicity, so because of safety profile and minor adverse effect of Silymarin, we can use it as prophylaxis against Cisplatin nephrotoxicity in various Cisplatin-contained chemotherapy regimens.
Malignancy, Prophylaxis, Renal failure
Ali Momeni, Ali Hajigholami, Shohreh Geshnizjani, Soleiman Kheiri. EFFECT OF SILYMARIN IN THE PREVENTION OF CISPLATIN NEPHROTOXICITY, A CLINICAL TRIAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2015 April [cited: 2019 Mar 18 ]; 9:OC11-OC13. Available from
Date of Submission: Dec 31, 2014
Date of Peer Review: Jan 29, 2015
Date of Acceptance: Feb 26, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: As declared above.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)