Salivary Visfatin Concentration in Response to Non-surgical Periodontal TherapyCorrespondence Address :
Dr. Fatemeh Baharak Ghaedi
Assistant Professor, Department of Periodontics, Dental School, Qazvin University of Medical Sciences, Qazvin, Iran.
Introduction: Visfatin is a pro-inflammatory cytokine that has been associated with several immunomodulating processes. The relationship between visfatin and periodontitis has been the subject of a few studies that have described visfatin as an inflammatory marker for periodontitis. However, studies on visfatin as a potential therapeutic target in periodontal diseases are scarce. In the present study, we evaluated the alterations in salivary visfatin levels in response to non-surgical periodontal treatment.
Materials and Methods: Twenty individuals with moderate to severe chronic periodontitis and twenty periodontally healthy individuals were selected for this study according to clinical parameters. Patients with chronic periodontitis were treated by non-surgical periodontal therapy. Clinical parameters were recorded and saliva samples were obtained from the control group and test group before (T1 group) and one month after periodontal treatment (T2 group). Salivary visfatin concentrations were measured by standard enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed with the statistical software SPSS, version 18.
Results: Visfatin was detectable in all samples. T1 and control groups were significantly different in terms of clinical parameters and visfatin levels. Visfatin concentrations were reduced significantly after non-surgical periodontal therapy. Periodontal treatment also resulted in significant reductions of all clinical parameters with the exception of clinical attachment level.
Conclusion: The results demonstrated that salivary levels of visfatin are reduced after non-surgical periodontal therapy to the levels comparable with those found in healthy individuals. Therefore, the salivary visfatin level may have the potential to be a target marker for assessment of responses to non-surgical periodontal therapy. However, more studies with larger sample sizes are necessary to validate these findings.
Adipokines, Chronic periodontitis, Nicotinamide phosphoribosyl transferase, Saliva, Therapy
Zahra Alizadeh Tabari, Fatemeh Baharak Ghaedi, Abbas Azadmehr, Ali Nohekhan,
Mohammad Amir Alizadeh Tabrizi, Mohammad Reza Talebi Ardakani, et al.. SALIVARY VISFATIN CONCENTRATION IN RESPONSE TO NON-SURGICAL PERIODONTAL THERAPY. Journal of Clinical and Diagnostic Research [serial online] 2015 April [cited: 2019 Oct 15 ]; 9:ZC05-ZC08. Available from
Date of Submission: Oct 09, 2014
Date of Peer Review: Feb 16, 2015
Date of Acceptance: Feb 25, 2015
Date of Publishing: Apr 01, 2015
Financial OR OTHER COMPETING INTERESTS: As declared in Acknolegements.
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