Molecular Subtypes in Locally Advanced Breast Cancer-Do They Have a Preferential Destination?Correspondence Address :
Dr. Prarthana Roselil Christopher,
Department of Radiotherapy, International Cancer Centre, Neyoor-629802, Tamil Nadu, India.
Introduction: The patterns of relapse in breast cancer are very much driven by the intrinsic molecular subtypes, which have been studied mainly in early stage breast cancer and have prognostic implications.
Aim: To explore the relationship between the different molecular subtypes and their predilection to a distinct distant metastatic site in locally advanced breast cancer.
Materials and Methods: This was a retrospective review of the records of 70 women with a histopathological diagnosis of locally advanced breast cancer who received radiation therapy between January 2011 and September 2012.
Results: In all the molecular subtypes, the most common site of metastasis is the most common first site of distant relapse as well. In luminal A it is the bone, in luminal B the liver and in triple negative and Human epidermal growth factor receptor 2 (HER2/neu) enriched it is the lung. But, the odds ratio was significant only among luminal A patients. There is no significant difference in disease free survival and overall survival between the molecular subtypes. But, luminal subtypes have a longer median survival (25 months) after the development of metastasis compared to non-luminal subtypes (7 months) with a p-value of 0.056.
Conclusion: Different molecular subtypes of locally advanced breast cancer have a preferential distant destination and difference in survival post detection of metastasis. A well-structured prospective study protocol with a longer follow up with a larger number of patients is required before tailor made surveillance protocols can be developed for the various molecular subtypes of locally advanced breast cancer.
Breast neoplasms, Immunohistochemistry, Oestrogen, Progesterone, Receptors
Prarthana Roselil Christopher, Pamela Alice Kingsley, Preety Negi, Sudeep Marcus, Jaineet Sachdeva, Clarence Samuel. MOLECULAR SUBTYPES IN LOCALLY ADVANCED BREAST CANCER-DO THEY HAVE A PREFERENTIAL DESTINATION?. Journal of Clinical and Diagnostic Research [serial online] 2018 December [cited: 2018 Dec 14 ]; 12:XC01-XC04. Available from
Date of Submission: Jun 06, 2018
Date of Peer Review: Jul 27, 2018
Date of Acceptance: Aug 20, 2018
Date of Publishing: Dec 01, 2018
Financial OR OTHER COMPETING INTERESTS: None.
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