Assessment of Non-surgical Periodontal Therapy on IL-22 and S100A12 Concentration in Gingival Crevicular FluidCorrespondence Address :
Dr. Ferial Taleghani,
Assistant Professor, Department of Periodontics, Faculty of Dentistry, Shahed University, Tehran, Iran.
Vesal Str. Italia Str. NO:39 PC : 14177.
Introduction: Periodontitis is a disease of the periodontal tissues that results in attachment loss and destruction of alveolar bone. Several risk factors such as bacteria, the host immune responses and genetics are considered.
Aim: The present study was undertaken to evaluate the effect of phase I periodontal treatment on the concentrations of IL-22 and S100A12 in patients with chronic periodontitis. Correlation between PD and CAL with the concentrations of IL-22 and S100A12 was also evaluated.
Materials and Methods: In this study, 22 patients (14 female and 8 male), with a mean age of 39.55±10.25 years, and moderate to severe periodontitis were included. GCF samples were obtained and then Phase I periodontal treatment was rendered. The subjects were recalled after four weeks for collecting samples. Wilcoxon’s signed-rank test was used to analyse concentration of S100 and IL-22 before and after the treatment with CAL and PD.
Results: There was an inverse correlation between the mean PD and S100 before treatment (p<0.05). In relation to CAL, although an inverse correlation was expected between CAL and S100 concentration, no significant correlation was found between them (p˜0.079).
Conclusion: The periodontal tissues are weak cellular sources for the secretion of IL-22 and S100. Given the inverse correlation between the concentration of S100 and the mean PD before treatment and also the inverse and significant correlation between the concentration of S100 and the decrease in CAL and PD after treatment, a possible protective role might be considered for S100 for the incidence of periodontitis and success of phase I treatment.
Chronic periodontitis, Dental scaling, ELISA, Interleukin 22, S100A12
Razieh Nejadi, Mandana Sattari, Ferial Taleghani. ASSESSMENT OF NON-SURGICAL PERIODONTAL THERAPY ON IL-22 AND S100A12 CONCENTRATION IN GINGIVAL CREVICULAR FLUID. Journal of Clinical and Diagnostic Research [serial online] 2018 December [cited: 2018 Dec 14 ]; 12:ZC19-ZC23. Available from
Date of Submission: Feb 07, 2018
Date of Peer Review: Apr 11, 2018
Date of Acceptance: Sep 18, 2018
Date of Publishing: Dec 01, 2018
Financial OR OTHER COMPETING INTERESTS: None.
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