Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based ApproachCorrespondence Address :
Dr. Mallineni Sreekanth Kumar,
Associate Professor, Department of Paedodontics and Preventive Dentistry, Narayana Dental College and Hospital, Nellore-524003, Andhra Pradesh, India.
Introduction: Metronidazole belongs to the nitroimidazole group of drugs, specifically anti-anaerobic in the nature and has a broad spectrum of activity against protozoa and anaerobic bacteria.
Aim: The purpose of this systematic review was to assess the requisite for metronidazole prescription among children with pulpal infection either during treatment or postoperatively.
Materials and Methods: An electronic literature search was done using databases PubMed, Cochrane Database of Systematic Reviews, OVID and EBSCO Host from January 1991 to December 2015. Hand search were carried outbased on cross-references, to find additional citations. Articles that met criteria such as randomised clinical trials, cross-sectional studies, in-vivo human studies were included. Search was confined to English language. The primary outcome was to evaluate the necessity of metronidazole prescription in children with pulpal pathology. Two independent evaluators were involved in the search and kappa statistics were used to evaluate intra & inter-examiner reliability.
Results: A total of 335 articles were available, among these, only two studies fulfilled established inclusion criteria. These available two studies were cross-sectional studies (Level III). Kappa statistics showed excellent inter and inter-examiner reliability.
Conclusion: Although, metronidazole has antibacterial properties against anaerobic microorganisms, there is no clear evidence regarding its prescription among children with pulpal pathology. Further research is required to support or contradict the use of metronidazole prescription in children during or after pulp therapies.
Antibiotics, Drug prescription, Nitromidazole group, Pulpitis
Nuvvula Sivakumar, Saha Anupam, Mallineni Sreekanth Kumar. PRESCRIPTION OF METRONIDAZOLE IN PAEDIATRIC DENTISTRY-AN EVIDENCE BASED APPROACH. Journal of Clinical and Diagnostic Research [serial online] 2018 December [cited: 2018 Dec 14 ]; 12:ZE08-ZE11. Available from
Date of Submission: Jun 14, 2018
Date of Peer Review: Jul 13, 2018
Date of Acceptance: Aug 31, 2018
Date of Publishing: Dec 01, 2018
Financial OR OTHER COMPETING INTERESTS: None.
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