Osteoclasts: Multifaceted Molecule in Vesicular TraffickingCorrespondence Address :
Dr. Jaideep Mahendra,
Department of Periodontics, Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, No. 1,
Alapakkam Main Road, Maduravoyal, Chennai-600095, Tamil Nadu, India.
It has been widely accepted that periodontitis is a result of the host immune inflammatory response caused by various periodontal microorganisms leading to tissue degradation and bone resorption. One important mechanism of the inflammatory mediators present in periodontal tissue is the stimulation and formation of osteoclasts that are believed to be the major cell type responsible for bone resorption. This review article comprehensively explains the various molecular activities of osteoclasts and their role in periodontitis.
Bone resorption, Inflammation, Periodontitis, Podosomes
Anil Kumar Kanakamedala, Jaideep Mahendra, Nashra Kareem, Little Mahendra. OSTEOCLASTS: MULTIFACETED MOLECULE IN VESICULAR TRAFFICKING. Journal of Clinical and Diagnostic Research [serial online] 2019 August [cited: 2019 Aug 20 ]; 13:ZE01-ZE05. Available from
Date of Submission: Nov 21, 2018
Date of Peer Review: Jan 07, 2019
Date of Acceptance: Jun 10, 2019
Date of Publishing: Aug 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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