A Study of Correlation of Disease Severity with Antibody Titers in Rheumatoid ArthritisCorrespondence Address :
Dr. Amarnath Dinakar Savur,
Department of Orthopaedics, Kasturba Medical College, Light House Hill Road, Mangalore-575001, Karnataka, India.
Introduction: Rheumatoid Arthritis (RA) is one of the most frequent autoimmune diseases in the world which affects about 1% of people. Anti-Cyclic Citrullinated Peptides (Anti-CCP) is shown to be more specific than rheumatoid factor in the diagnosis of RA. This test becomes positive in early stage of disease and it has a high predictive value.
Aim: To correlate the relationship between anti-CCP antibody and rheumatoid factor titers and disease activity scores.
Materials and Methods: A cross-sectional study was performed in 50 patients with RA for evaluating the relation between anti-CCP antibody titer and Disease Activity Score 28 (DAS28), Simplified Disease Activity Index (SDAI) and Clinical Disease Activity Index (CDAI). A detailed examination of each patient including their demographic characteristics, duration of disease, number of tender and swollen joints, ESR and C-reactive protein, patient’s and physician’s global assessment by VAS (0-10) and titers of rheumatoid factor and anti-CCP antibody. Patients who fulfilled the ACR-EULAR 2010 criteria were included. The statistical analysis was done using Pearson’s correlation coefficient. A p-value of less than 0.05 was considered significant.
Results: Of the 50 patients which were included (mean age, 44.82 range, 18-70), 38 were females and 12 were males. Mean ESR was 54±27 mm/hr and Mean CRP was 17.277±23.41 mg/dL. Mean DAS 28 was 5.955±0.962; mean SDAI was 46.9±27.1 and CDAI 28.9±10.8. There was positive correlation (p<0.001) between DAS28 and SDAI (r=0.550) and CDAI (r=0.808). Anti-CCP level was associated with SDAI (r=0.317) and CDAI (r=0.282) (p<0.05).
Conclusion: There was significant correlation in the titers of anti-CCP and disease activity indices-SDAI and CDAI. Patients with higher levels of anti-CCP antibody had greater activity.
Anti-cyclic citrullinated peptides, Autoimmune disease, Disease activity indices, Rheumatoid factor
Praveen Singh Madan, Amarnath Dinakar Savur, Surendra Umesh Kamath, Shrikala Baliga, Sharan Mallya. A STUDY OF CORRELATION OF DISEASE SEVERITY WITH ANTIBODY TITERS IN RHEUMATOID ARTHRITIS. Journal of Clinical and Diagnostic Research [serial online] 2019 February [cited: 2019 Mar 26 ]; 13:RC08-RC11. Available from
Date of Submission: Oct 25, 2017
Date of Peer Review: Jan 24, 2018
Date of Acceptance: Nov 29, 2018
Date of Publishing: Feb 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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