Primary Squamous Cell Carcinoma of the Excretory Duct of the Submandibular Gland: A Rare CaseCorrespondence Address :
Dr. Vera Cavalcanti de Araújo,
Professor, Department of Pathology and Cell Biology, São Leopoldo Mandic Research Institute, Rua José Rocha Junqueira, 13, Campinas, SP, Brazil.
Primary Squamous Cell Carcinoma (SCC) of the salivary glands is a very rare disease and establishing the true origin of an SCC manifesting in a salivary gland is always a daunting task, due to the natural proximity of salivary glands to surface epithelia. The aim of this report is to describe and discuss an SCC originating from the excretory duct of the submandibular gland with an unusual histological papillary appearance. A 39-year-old male presented with a slow growing mass in the floor of the mouth, which was clinically nodular, exophytic and ulcerated. Histological examination revealed a predominantly papillary architecture surrounding an intact salivary duct, which showed mucicarmine-positive material and no cell atypia. The duct was in a continuum with the neoplastic tissue, disposed as sheets of basaloid cells with foci of dysplastic squamous epithelium with minimal keratinization. The lesion was positive to CK14 throughout the parenchyma, CK7 in the luminal cells of ductal structures, CK13 in rare epidermoid areas and generally to AE1/AE3, highlighting foci of keratinization. The case reported herein is a very rare neoplasm in an unprecedented intraoral site, which emphasises the importance of histochemistry and immunohistochemistry in the diagnosis of rare lesions.
Immunohistochemistry, Malignancy, Salivary gland tumours, Wharton’s duct
Victor Angelo M Montalli, Marcelo Sperandio, Andresa Borges Soares, Antonio D Albuquerque Neto, Vera Cavalcanti DE Araújo. PRIMARY SQUAMOUS CELL CARCINOMA OF THE EXCRETORY DUCT OF THE SUBMANDIBULAR GLAND: A RARE CASE. Journal of Clinical and Diagnostic Research [serial online] 2019 January [cited: 2019 Jan 22 ]; 13:ED14-ED16. Available from
Date of Submission: Aug 15, 2018
Date of Peer Review: Aug 30, 2018
Date of Acceptance: Oct 23, 2018
Date of Publishing: Jan 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: As mentioned above.
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2016: 132.37
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)