Diffuse Nodular Pseudoangiomatous Stromal Hyperplasia causing Bilateral Gigantomastia with Follow-up of 2 Year Post Reduction MammoplastyCorrespondence Address :
Dr. Teena Sleeba,
1401, Oceanus Maple, Edapally, Kochi-682024, Kerala, India.
Pseudoangiomatous Stromal Hyperplasia (PASH) is an uncommon benign mesenchymal tumour of the breast with no known potential for malignancy. PASH is often detected incidentally or in a background of other breast pathologies. Being hormonally driven, these are most commonly seen in women in the reproductive age group. The size of the PASH varies with small microscopic PASH being much more common than the tumourous or infiltrative varieties. It is uncommon to see PASH presenting as diffuse nodular masses replacing the entire glandular parenchyma symmetrically on both sides. We report a case of a 31-year-old non lactating lady, in whom PASH caused bilateral symmetrical gigantomastia. As PASH has been shown to have a high chance of recurrence, review of literature revealed that most women with PASH-associated gigantomastia undergo mastectomy rather than reduction mammoplasty. We followed up our patient for two years post-reduction mammoplasty with no increase in dimensions of existing lesions or development of new lesions both clinically and on imaging.
Benign mesenchymal tumour, Diffuse nodular mass, Malignancy
Teena Sleeba, Jojoe John, Gigy Raj Kulangara, Madhu Sudheendran, Sunita Thomas. DIFFUSE NODULAR PSEUDOANGIOMATOUS STROMAL HYPERPLASIA CAUSING BILATERAL GIGANTOMASTIA WITH FOLLOW-UP OF 2 YEAR POST REDUCTION MAMMOPLASTY. Journal of Clinical and Diagnostic Research [serial online] 2019 March [cited: 2019 Mar 24 ]; 13:TD06-TD08. Available from
Date of Submission: Dec 03, 2018
Date of Peer Review: Jan 09, 2019
Date of Acceptance: Jan 18, 2019
Date of Publishing: Mar 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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