Pyridoxine: The ‘Ba.Six’ of use in Nausea and Vomiting of PregnancyCorrespondence Address :
Dr. Malpe Surekha Bhat,
St Helenastraat, Oranjestad, Aruba.
Over the centuries, the dietary and biochemical essentiality of pyridoxine in the humans has been well established. Apart from various physiological functions, pyridoxine is therapeutically important in Nausea and Vomiting of Pregnancy (NVP). Pyridoxine on its own or a combination of pyridoxine (vitamin B6) (pregnancy category A) and doxylamine (category B), previously available as Bendectin, is the only medication that is specifically labeled for the treatment of NVP by the Food and Drug Administration. Although various reports claims the efficacy of pyridoxine in NVP, there are a very few studies on its mechanism of action in relieving the symptoms. Therefore, the present review was aimed at revisiting relevant previous data and providing the necessary background to discuss the chemistry, pharmacochemistry, status in pregnancy and mechanism/s of action in NVP of this B-complex vitamin in detail.
Deficiency, Fetal uptake, Hyperemesis gravidarum, Supplementation, Vitamin B6
Abbas Hassan, Arun Kumar Dubey, Malpe Surekha Bhat. PYRIDOXINE: THE ‘BA.SIX’ OF USE IN NAUSEA AND VOMITING OF PREGNANCY. Journal of Clinical and Diagnostic Research [serial online] 2019 May [cited: 2019 May 22 ]; 13:BE01-BE06. Available from
Date of Submission: Jan 07, 2019
Date of Peer Review: Feb 02, 2019
Date of Acceptance: Mar 26, 2019
Date of Publishing: May 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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