Pemphigus Vulgaris: Case Report and Review of LiteratureCorrespondence Address :
Dr. Gokul Sridharan,
Institutional Area, Sector 4, Kharghar, Navi Mumbai, Maharashtra, India.
Autoimmune mucocutaneous disorders of oral cavity constitute an important group of lesions that pose diagnostic, therapeutic and prognostic difficulties to the dental clinician. Pemphigus vulgaris is an autoimmune blistering condition that usually affects the oral mucosa and is characterised by autoantibodies directed against the desmoglein component of the keratinocytes. It manifests clinically as vesicles, bullae or desquamative gingivitis and histopathologically shows the presence of acantholysis. Immunofluorescent demonstration of IgG antibodies against desmoglein usually confirms the diagnosis. The resemblance in clinical appearance to other oral diseases mandates the inclusion of pemphigus vulgaris in the differential diagnosis of oral vesiculo-bullous lesions. Adequate knowledge of diagnostic and therapeutic modalities helps the clinician in appropriate management. This paper presents a case report of pemphigus vulgaris affecting both oral cavity and skin along with a brief review of literature.
Autoimmune disorders, Oral mucosa, Pemphigus vulgaris
Preeti Ahankare, Divyesh Wankhedkar, Sangeeta Patankar, Gokul Sridharan. PEMPHIGUS VULGARIS: CASE REPORT AND REVIEW OF LITERATURE. Journal of Clinical and Diagnostic Research [serial online] 2019 May [cited: 2019 May 19 ]; 13:ZD04-ZD06. Available from
Date of Submission: Jan 05, 2019
Date of Peer Review: Feb 14, 2019
Date of Acceptance: Mar 16, 2019
Date of Publishing: May 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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