Hereditary Gingival Fibromatosis: Report of Family Pedigree of Three GenerationsCorrespondence Address :
Dr. Jaideep Mahendra,
Faculty of Dentistry, Meenakshi Academy of Higher Education and Research, Meenakshi Ammal Dental College and Hospital, Chennai-600095, Tamil Nadu, India.
Gingival enlargement or gingival overgrowth can be defined as increase in the size of gingiva, caused due to a variety of etiological factors. One of the causes of gingival enlargement is hereditary gingival fibromatosis, which is a genetic disorder characterised by progressive enlargement of the free and attached gingiva. It may have a nodular enlargement, having stippled surfaces with no inflammation or may show inflamed surface. Clinically, gingiva may present dense or firm surface on palpation. It is commonly associated with mutation of Son of Sevenless-1 (SOS-1) gene, which is responsible for this disease. This case report focuses on a family, diagnosed with hereditary gingival fibromatosis in three consecutive generations. This report also discusses the diagnosis, treatment, histopathological features and the pattern of inheritance associated, which is emphasised through pedigree analysis.
Electrocoagulation, Gingival overgrowth, Gingivectomy, Pedigree
Jaideep Mahendra, Vijayalakshmi Rajaram, Sujeetha Muthukumar, Sathish Rajendran. HEREDITARY GINGIVAL FIBROMATOSIS: REPORT OF FAMILY PEDIGREE OF THREE GENERATIONS. Journal of Clinical and Diagnostic Research [serial online] 2019 May [cited: 2019 May 19 ]; 13:ZD13-ZD17. Available from
Date of Submission: Jan 08, 2019
Date of Peer Review: Mar 07, 2019
Date of Acceptance: Mar 25, 2019
Date of Publishing: May 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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