Role of Microbiota in Aetiopathogenesis of Colorectal CancerCorrespondence Address :
Dr. Arpita Suri,
B-607/A, Sushant Lok, Phase 1, Gurugram, Haryana, India.
Colorectal Cancer (CRC) accounts for sizeable disease burden globally. The symbiotic association between gut inhabitants and the digestive tract contributes to gut homeostasis. Studies suggest that altered microbiota composition or dysbiosis can contribute to colorectal carcinogenesis. This review outlines the complex interplay between the microbiome, diet and CRC with a special emphasis on microbial metabolites, gut barrier function, specific bacterial species which influence the micro environment by various mechanisms like oxidative stress, DNA damage, immune modulation and inflammation. This would help in establishing novel diagnostic, prognostic markers and newer therapeutics for CRC.
Butyrate, Dysbiosis, Gut microbiota, Microbiome
Arpita Suri, Sanjiv Kumar Bansal, Prajwal Ammalli, Busi Karunanand. ROLE OF MICROBIOTA IN AETIOPATHOGENESIS OF COLORECTAL CANCER. Journal of Clinical and Diagnostic Research [serial online] 2019 September [cited: 2019 Sep 18 ]; 13:BE01-BE05. Available from
Date of Submission: Jul 15, 2019
Date of Peer Review: Jul 27, 2019
Date of Acceptance: Aug 17, 2019
Date of Publishing: Sep 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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