A Rare Presentation of Gall Bladder (GB) Mass in the Form of Mixed Adenoneuroendocrine Carcinoma (MANEC): A Case ReportCorrespondence Address :
Flat Number 201, Basudev Bihar Apartment, Nageshwar Coloney, Parmanand Path, Patna, Bihar, India.
Primary Neuroendocrine Carcinoma (NEC) of gall bladder is extremely rare. The diagnosis is incidental in most cases. Here, we present a case of Mixed Adenoneuroendocrine tumour (MANEC) in a 48-year-old female who presented with pain in abdomen, nausea and loss of appetite and diffuse non-tender lump in right hypochondrium. CECT abdomen showed distended Gall Bladder (GB) with intraluminal polypoidal mass, with multiple liver and retroperitoneal metastasis. Histopathological and immunohistochemistry study revealed MANEC in GB with NEC metastasis in liver. This case highlights the rarity of the disorder and role of immunohistochemical studies and therefore MANEC should be considered as a differential to GB carcinoma.
Gall bladder, Immunohistochemistry, Malignant
Rishikant Sinha, Pranav Kumar Santhalia, Prem Kumar, Punam Prasad Bhadani. A RARE PRESENTATION OF GALL BLADDER (GB) MASS IN THE FORM OF MIXED ADENONEUROENDOCRINE CARCINOMA (MANEC): A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2019 April [cited: 2019 Apr 25 ]; 13:TD01-TD02. Available from
Date of Submission: Nov 19, 2018
Date of Peer Review: Dec 11, 2018
Date of Acceptance: Feb 25, 2019
Date of Publishing: Apr 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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