Comparison of Propofol Alone and Propofol-Ketamine Mixture for Sedation during Endoscopic Retrograde Cholangiopancreatography (ERCP): A Randomised StudyCorrespondence Address :
Dr. Mukesh Kumar Prasad,
Associate Professor, Department of Anaesthesia, Teerthankar Mahaveer Medical College and Research Centre, Teerthanker Mahaveer University, Moradabad-244001, Uttar Pradesh, India.
Introduction: Propofol is frequently used for deep sedation for Endoscopic Retrograde Cholangiopancreatography (ERCP). Sedation-Related Adverse Events (SRAEs), associated with propofol administration, include hypotension, arrhythmia, oxygen desaturation, unplanned intubation and procedure termination whereas, ketamine propofol combination has favourable haemodynamic effects.
Aim: To evaluate the efficacy of the synergistic effect of small dose of ketamine (25 mg) and propofol in comparison with propofol alone on propofol consumption for deep sedation in patients undergoing ERCP.
Materials and Methods: A total of 60 patients undergoing ERCP were randomly assigned to one of the two medication regimens through chit and box method. Patients in Group 1 (n=30) received only intravenous propofol, while patients in Group 2 (n=30) received 25 mg of i.v. ketamine along with intravenous propofol and both groups of patients were titrated to achieve deep sedation. Total propofol consumption was recorded in both groups.
Results: Patients in both groups were comparable in terms of BMI, ASA status and duration of ERCP. Group 1 patients required significantly higher doses of propofol (370±123.4 mg) as compared with Group 2 (342.65±116.4 mg). The mean percentage decline in oxygen saturation during the procedure was greater in Group 1 than it was in Group 2.
Conclusion: Authors concluded that during ERCP addition of ketamine to propofol resulted in decrease in propofol consumption without disturbing intra and post-procedure haemodynamic stability.
Consumption, Endoscopic retrograde, Ramsay sedation
Aditya Garg, Mukesh Kumar Prasad, Gurdeep Singh Jheetay, Rohit Kumar Varshney, Amit Kumar Choudhary, Himani Saroha Garg. COMPARISON OF PROPOFOL ALONE AND PROPOFOL-KETAMINE MIXTURE FOR SEDATION DURING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP): A RANDOMISED STUDY. Journal of Clinical and Diagnostic Research [serial online] 2019 April [cited: 2019 Apr 25 ]; 13:UC01-UC03. Available from
Date of Submission: Dec 22, 2018
Date of Peer Review: Jan 11, 2019
Date of Acceptance: Feb 21, 2019
Date of Publishing: Apr 01, 2019
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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