Correlation of Auditory Event Related Potential (P300) and Mini Mental State Examination to Measure Cognitive Function in Healthy Young Adults: A Pilot StudyCorrespondence Address :
Professor, Department of Physiology, RUHS College of Medical Sciences, Jaipur, Rajasthan, India.
Introduction: Cognition is composed of intellectual function, memory, speech and language, complex perception, orientation, attention, judgment, planning and decision-making. Behaviour is the exhibition of these cognitive functions. Cognitive function can be assessed by different methods. The most commonly used are P300 and Mini Mental State Examination (MMSE). As both measures evaluate cognitive functions but objective method P300 evaluate endogenously and give the best picture of cognitive functions.
Aim: To check the correlation between the results of MMSE with event related potential (P300).
Materials and Methods: A prospective cross-sectional study was done on 100 healthy young adult subjects of both genders, aged between 18-25 years after taking written informed consent from January 2019 to June 2019. Cognitive functions were assessed by using MMSE questionnaire through face to face interview and event related potential (P300) latency and amplitude were assessed by using octopus NCV/EMG/EP- 4 Ch. Machine (model- CMEMG 01). Pearson correlation was performed to identify correlation.
Results: The mean MMSE score was 24.28±2.89. The mean P300 (latency and amplitude) was 269.61±43.11 ms and 3.1±4.13 ÂµV. Pearson correlation were used to calculate the correlation between P300 (latency and amplitude) with MMSE. The inverse correlation (-0.086) was in between P300 latency and MMSE. There was no correlation between P300 amplitude and MMSE.
Conclusion: There was no correlation established between P300 amplitude and MMSE and inverse correlation was seen between P300 latency and MMSE. Hence, P300 cannot replace the MMSE in clinical settings.
Cognition, Event related potential, Mini mental state examination
Date of Submission: Nov 04, 2019
Date of Peer Review: Nov 27, 2019
Date of Acceptance: Jan 21, 2020
Date of Publishing: Mar 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Nov 05, 2019
• Manual Googling: Jan 21, 2020
• iThenticate Software: Feb 07, 2020 (15%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
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- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)