Vitamin D Levels in Gestational Diabetes Mellitus and its Influence on Future Type 2 Diabetes Mellitus- An Observational StudyCorrespondence Address :
Dr. Shenbaga Lalitha Sankar,
No. 14, Kalpavriksha Apartment, Second Floor, Mahadevan Street, Nehru Nagar, Chromepet, Chennai-600044 (Near Vivekananda Vidyalaya), Tamil Nadu, India.
Introduction: Gestational Diabetes Mellitus (GDM) and persistent hyperglycaemia postpartum is a rising health challenge. Multiple researches have contributed to the understanding of the magnitude of the causal factors involved. One such factor is Vitamin D deficiency though, widely studied exact role in development of Diabetes Mellitus (DM) is not investigated.
Aim: To predict the risk of pre-diabetes and DM in GDM patients with Vitamin D deficiency.
Materials and Methods: Hundred pregnant women were recruited-50 study group, 50 control group; based on WHO criteria for GDM diagnosis at 24-28 weeks of gestation. Study parameters in antepartum period were maternal age, Body Mass Index (BMI), Vitamin D, Fasting blood glucose, 2 hour Oral Glucose Tolerance Test (OGTT). Study parameters in postpartum follow-up were fasting blood glucose, postprandial blood glucose, vitamin D. Mann-Whitney U-test and Binary Logistic regression analysis were the statistical tools used to predict the risk.
Results: Antepartum Vitamin D deficiency (<20 ng/mL) showed 2.2 fold significantly increased risk for developing pre-diabetes and DM. High frequency of pre-diabetes (52% of cases) postdelivery (6 weeks) was proved. Maternal age, BMI and OGTT values had direct relationship in predicting risk of DM which was proved with postpartum follow-up.
Conclusion: Vitamin D deficiency has a significant role in development of pre-diabetes and DM in GDM patients.
Biomarker, Glucose intolerance, Pre-diabetes, Risk prediction, Vitamin D deficiency
Date of Submission: Feb 25, 2020
Date of Peer Review: Mar 25, 2020
Date of Acceptance: Apr 21, 2020
Date of Publishing: May 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
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- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)