Correlation of Placental Growth Factor with Pre-Eclampsia during Mid Trimester of Pregnancy: A Case Control Study at Liaquat University of Medical and Health Sciences, PakistanCorrespondence Address :
Khalid Yousuf Memon,
Lecturer, Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan.
Introduction: Pre-Eclampsia (PE) is the common multisystem disorder which complicates the pregnancies 3-8% and a major cause of morbidity and mortality throughout the world.
Aim: To determine the correlation of placental growth factor with pre-eclampsia in mid trimester of pregnancy at Liaquat University of Medical and Health Sciences Jamshoro.
Materials and Methods: This Case-Control study was performed at Pathology Department with Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro/Hyderabad, during 12 months, from 06-02-2017 to 05-02-2018. Pregnant women with mid trimester were enrolled in the study. Group A included females with Pre-eclampsia, while Group B were normotensive females of same gestation. Their Blood sample were collected and stored at -80°. Level of Placental Growth factor was measured on Elecsys system. Data was analysed via SPSS version 20.
Results: Total 384 pre-eclampsia females were selected and 50 females without hypertension were studied as control. Mean age of patients was 27.46+3.91 years. No significant variance was seen between mean of gestational age of patients and normal pregnant females; p-value 0.346. Mean of placental growth factor was insignificantly decreased 35.21±31.68 pg/mL among patients in contrast to normal women as 47.23±56.13 pg/mL, p=0.081. A negative correlation was found between blood pressure and placental growth factor, r-values 0.004 and 0.001 respectively.
Conclusion: It was concluded that serum placental growth factor was the poor marker for pre-eclampsia, as it showed weak negative correlation with pre-eclampsia.
Hypertension, Marker, Normotensive, Pregnant women
Date of Submission: Apr 08, 2020
Date of Peer Review: May 27, 2020
Date of Acceptance: Oct 19, 2020
Date of Publishing: Nov 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
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- Popline (reproductive health literature)