Prescribing Pattern of Proton Pump Inhibitors (PPI) and Histamine Blockers in a Tertiary Care HospitalCorrespondence Address :
Alpa Pragnesh Gor,
Professor, Department of Pharmacology, Pramukhswami Medical College, Karamsad, Gujarat, India.
Introduction: Gastric Problems are the most common diseases seen in many countries for which majority of the population prefer Proton Pump Inhibitors (PPI) and Histamine (H2) Blockers. They are prescribed most commonly for Gastroesophageal Reflux Disease (GERD), Dyspepsia, Peptic Ulcer Disease, along-with medications like Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and other drugs. Concerns have been raised about the increasing costs associated with prescription of these drugs as they are often prescribed for minor symptoms and without clear indications. Prescribing pattern should be evaluated periodically to promote rational use of medicines.
Aim: To assess the prescribing pattern of PPIs and H2 Blockers in Surgery and Medicine Department of a Tertiary Care Hospital.
Materials and Methods: An observational study was conducted in a Tertiary Care Hospital, Karamsad over a period of one year from November, 2018 to October, 2019, among patients visiting to Out Patient Department (OPD) and in Patient Department (IPD) of Medicine and Surgery Department that were prescribed PPI and H2 Blockers. Total 1100 prescriptions and 1265 PPI, H2 Blockers were analysed. The data were analysed for socio-demographic variables along with details of PPI and H2 Blockers. Co-prescribing drugs, Fixed Dose Combinations (FDCS) and drug interactions of each prescription was analysed.
Results: In the study, PPI and H2 Blockers were prescribed more in males (54.36%). The predominant age group was 18-40 years (42%). Among studied drugs, most commonly prescribed single drug was Pantoprazole and FDC was Ranitidine + Domperidone. The drugs were most commonly prescribed through oral route (90.9%). They were most commonly prescribed along with an NSAID for gastro-protection (28.9%). Pharmacokinetic drug interactions were observed more in the study.
Conclusion: This study showed that physicians prescribe PPI and H2 Blockers as a comedication for gastroprotection. There is a need to increase documentation for prescribing PPI and H2 Blockers.
Acid peptic disease, Appropriateness, Fixed-dose combinations
Date of Submission: May 20, 2020
Date of Peer Review: Jun 23, 2020
Date of Acceptance: Sep 07, 2020
Date of Publishing: Oct 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? No
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: May 21, 2020
• Manual Googling: Aug 17, 2020
• iThenticate Software: Sep 28, 2020 (1%)
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