Prothrombotic State and Cardiovascular Risk in Hyperuricaemic Individuals: Does Hyperglycaemia Play a Role? A Case-control StudyCorrespondence Address :
Dr. Shilpa Bhardwaj,
186, Ground Floor, Sharda Niketan, Pitampura, Delhi-34, India.
Introduction: The role of Hyperuricaemia (HU) in pathogenesis of cardiovascular disorders is debated. A number of hypothetical mechanisms that link HU to increased cardiovascular risk are researched.
Aim: To evaluate the hypercoagulable state and cardiovascular risk in diabetic hyperuricaemics, nondiabetic hyperuricaemics in comparison to healthy controls, and to analyse whether chronic hyperglycaemia has a causal role in HU associated cardiovascular risk.
Materials and Methods: A case-control study was conducted in which 60 known hyperuricaemic cases and 30 healthy controls were included in the study. Cases were further divided into nondiabetic hyperuricaemic and diabetic-hyperuricaemic subgroups. Routine blood biochemistry including high sensitivity C-Reactive Protein (hs-CRP), Plasminogen Activator Inhibitor-1 (PAI-1) and lipid profile was performed to assess endothelial function and hypercoagulability. Data were expressed as Mean±SEM.
Results: Levels of hs-CRP and PAI-1 were significantly higher in diabetic hyperuricaemics (p<0.001) and nondiabetic hyperuricaemics (p<0.001) compared to controls. The difference was not significant between the hyperuricaemic subgroups. Serum Uric Acid (UA) levels showed a significantly positive correlation with hs-CRP (r=0.554, p<0.001) and PAI-1 (r=0.525, p=0.003) levels among the cases. Association between UA and glucose was not significant in diabetic hyperuricaemics (r=0.270, p=0.15).
Conclusion: HU is associated with endothelial dysfunction and prothrombotic state leading to increased cardiovascular risk. Hyperglycaemia does not have a direct causal role in HU associated cardiovascular risk.
Cardiovascular morbidity, Endothelial dysfunction, Hyperglycaemics
Date of Submission: May 07, 2020
Date of Peer Review: May 15, 2020
Date of Acceptance: Jul 14, 2020
Date of Publishing: Sep 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
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- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
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- Popline (reproductive health literature)