
Rare Dysplastic Gangliocytoma of Cerebellum: A Case Report
Correspondence Address :Dr. Nidhish Kumar,
C/O Dr. Mohan Singh, Jagat Narayan Road, Kadam Kuan, Opposite Indralok Appartment, Patna, Bihar, India.
E-mail: drnidhishkumar@gmail.com
Lhermitte and Duclos first described Dysplastic Gangliocytoma in 1920. Lhermitte Duclos Disease (LDD) is an extremely rare disorder of uncertain prognosis and pathogenesis. LDD is recognised as a part of Cowden Disease, which being an autosomal-dominant phacomatosis and cancer syndrome. Till date only about 225 cases of LDD have currently been reported in medical literature. It is most commonly seen in young adults with a peak incidence in third or fourth decade with signs and symptoms of cerebellar dysfunction or increased intracranial pressure leading to obstructive hydrocephalus. A 36-year-old female came to Neuromedicine Outpatient Department (OPD) in a Tertiary Care Superspecialty Hospital with chief complaints of headache and vomiting, difficulty in swallowing liquid food since two months with no significant family history. The patient’s general condition was not good with significant weakness on presentation. The patient was conscious, oriented with pulse rate of 78/bpm, blood pressure of 118/80 mm of Hg with bilateral clear chest with normal S1 S2 sound. The Glasgow Coma Scale (GCS) was found to be Eye response-4, Verbal response-5, Motor response-6. Magnetic Resonance Imaging (MRI) of patient showed large heterogeneous non-enhancing lesion involving left cerebellar hemisphere, vermis and cerebellar peduncle with widened cerebellar folia with a "Tigroid appearance". A diagnosis of Cerebellar Gangliocytoma was made and was treated successfully with surgery and diagnostically proven with biopsy and immunohistochemistry. The background history of Cowden syndrome was not present in index case.
Cerebellar gangliocytoma, Cowden syndrome, Obstructive hydrocephalus, Tigroid appearance
DOI: 10.7860/JCDR/2020/45479.14087
Date of Submission: Jun 14, 2020
Date of Peer Review: Jul 14, 2020
Date of Acceptance: Aug 22, 2020
Date of Publishing: Oct 01, 2020
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jun 15, 2020
• Manual Googling: Aug 21, 2020
• iThenticate Software: Sep 17, 2020 (7%)
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