C-Reactive Protein as a Predictor for Early Intervention in Patients with Ureteric Calculus- A Prospective StudyCorrespondence Address :
Dr. Suraj Hegde,
Associate Professor, Department of Urology, K S Hegde Medical Academy, Nityananda
Nagar, Mangalore-575018, Karnataka, India.
Introduction: Inflammation of ureteric wall may impede the passage of calculus which reduces the chances of spontaneous expulsion. C-Reactive Protein (CRP) being an acute phase reactant elevates in almost all inflammatory conditions.
Aim: To determine whether CRP levels can predict the need for early intervention in symptomatic ureteric calculus.
Materials and Methods: The sample was estimated to be 140 patients over the age of 18 years during the study duration of six months. Ureteric calculus measuring 5-10 mm were subjected to Medical Expulsion Therapy (MET) (Silodosin 8 mg at night). CRP levels were estimated on day 1 and day 7 from the presentation. CRP less than 6 mg/L was considered normal, represented as â€˜negativeâ€™ in the present study; more than or equal to 6 mg/L was taken as â€˜positiveâ€™. Patients who demonstrated rising/ elevated CRP were considered for early endoscopic/surgical intervention. Data was analysed by Statistical Package for the Social Sciences (SPSS) v19.00.
Results: Out of the 140 patients, 56 patients had positive CRP on day 7, of which only nine patients had expelled the stone at the end of two weeks (16.07%). Out of 84 negative CRP group patients, 56 showed evidence of spontaneous calculus expulsion within one week and 18 patients at the end of two weeks and 10 patients did not demonstrate spontaneous expulsion at the end of two weeks and required intervention. The present study showed a statistically significant correlation between the positive CRP levels and the rates of spontaneous expulsion of ureteric calculus (p=0.0001).
Conclusion: CRP can be used as a predictor for an early intervention of symptomatic ureteric calculus.
Inflamation, Ureteric coli, Urolithiasis
Date of Submission: Jun 10, 2020
Date of Peer Review: Jul 14, 2020
Date of Acceptance: Aug 13, 2020
Date of Publishing: Oct 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jun 11, 2020
• Manual Googling: Aug 06, 2020
• iThenticate Software: Sep 29, 2020 (8%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)