Comparison of Incidence of Postoperative Sore Throat after Nebulisation with Ketamine, Lignocaine and Magnesium Sulphate- A Randomised Controlled TrialCorrespondence Address :
Dr. Manjit Singh,
193-B, Street 3-A, Gopal Nagar, Majitha Road, Amritsar, Punjab, India.
Introduction: Recent advances in anaesthesia ensures better postoperative outcome. Postoperative Sore Throat (POST) is prevalent in patients after tracheal intubation, leading to significant discomfort thereby increasing the length of hospital stay.
Aim: To compare the efficacy of preoperative nebulisation with ketamine, lignocaine and magnesium sulphate for attenuating risk of POST at different time intervals.
Materials and Methods: Total of 120 patients were randomly divided into four groups of 30 each, and were preoperatively nebulised with 50 mg Ketamine (group A), 40 mg of 4% Lignocaine (group B), 225 mg of Magnesium Sulphate (group C) and distilled water (group D). POST score was recorded at 0, 2, 4, 6, 8, 12 and 24 hour postoperatively using four point scale. The analysis was done by student’s t-test and chi-square test. The p<0.05 was considered statistically significant.
Results: The overall incidence of POST was 37.5% (45/120). In Group A, the incidence of POST was observed to be 13% (4/30). In Group B, the incidence was 43% (13/30), in Group C it was 36% (11/30), and in group D it was 56% (17/30). On intergroup comparison of incidence and severity, a statistically significant difference was observed at 4th and 6th hour (p<0.05).
Conclusion: Preoperative nebulisation with all the three drugs ketamine, magnesium sulphate and lignocaine is a simple and effective way to reduce the incidence of Sore Throat (ST) in patients undergoing tracheal intubations under General Anaesthesia (GA). The maximum reduction in POST was seen with ketamine followed by magnesium sulphate and then lignocaine.
Endotracheal intubation, Genral anaesthesia, Nebulise
Date of Submission: Feb 27, 2020
Date of Peer Review: Apr 06, 2020
Date of Acceptance: Apr 23, 2020
Date of Publishing: Jun 01, 2020
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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