Celiac Disease in Children with Chronic Diarrhoea: A Cross-sectional StudyCorrespondence Address :
Dr. YM Bhavika,
Devagiri, House No 234, Shankaripuram Main Road, Hassan-573201, Karnataka, India.
Introduction: Celiac disease is a chronic gastrointestinal disorder, very often underdiagnosed due to lack of awareness among the general practitioners.
Aim: To study the prevalence of celiac disease among children with chronic diarrhoea.
Materials and Methods: A cross-sectional study was conducted in which, 890 children between the age group of 1-18 years with history of chronic diarrhoea (loose stools or increased frequency for more than two weeks) were enrolled, between November 2015 and January 2018 in a tertiary care centre in India. The children were screened with serological tests for celiac disease and among those who were tested positive; the diagnosis was confirmed by intestinal biopsy.
Results: Of the 890 patients with chronic diarrhoea, 252 (28.3%) were tested positive for anti-tissue Transglutaminase (tTG) antibodies with levels more than 10 times the upper normal limit. Among the 252 patients with positive serology, 144 patients had intestinal biopsy findings suggestive of celiac disease (Marsh stage 3b and 3c) while the rest had normal or mild (marsh grade 1, 2 and 3a) histological changes.
Conclusion: Celiac disease is one of the most important causes of chronic diarrhoea and hence should be actively looked for in children presenting with chronic diarrhoea.
Chronic gastrointestinal disorder, Duodenal biopsy, Serology
Date of Submission: Sep 22, 2020
Date of Peer Review: Oct 12, 2020
Date of Acceptance: Dec 08, 2020
Date of Publishing: Jan 01, 2021
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. No
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• iThenticate Software: Dec 17, 2020 (11%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
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- Directory of Open Access Journals (DOAJ)
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- Popline (reproductive health literature)