Evaluation of Salivary C-Reactive Protein and Psychological Factors in Patients with Oral Lichen Planus: A Case-control StudyCorrespondence Address :
Shruti Anand Patil,
Department of Oral Medicine and Radiology, Sinhgad Dental College and Hospital,
S. No. 44/1, Vadgaon (Bk) Off Sinhgad Road, Pune, Maharashtra, India.
Introduction: Aetiology and pathogenesis of Oral Lichen Planus (OLP) has been the focus of research since a long time and various aetiological factors like autoimmunity, heredity, drugs, dental materials, psychological factors, especially stress and anxiety have been reported to be associated with this disease. Few studies in the past have found significant elevations in C-Reactive Protein (CRP) levels in individuals who reported to be having chronic stress. Both altered salivary CRP levels and psychological stress have been reported in OLP patients. To the best of our knowledge no such studies have been conducted in the past, so a need was felt to conduct a study to evaluate and also correlate salivary CRP and psychological factors in OLP patients.
Aim: To evaluate salivary CRP and psychological factors and assess the possible correlation between them in patients with OLP.
Materials and Methods: This case-control study included two groups: group A- consisted of 33 individuals clinically diagnosed with OLP and group B- consisting of 33, age and gender matched healthy individuals. Hospital Anxiety and Depression Scale (HADS) was used for all the participants to evaluate the psychological factors. Salivary CRP levels were evaluated using Mispa i2 Nephelometry. Statistical analysis was done using SPSS software version 21.
Results: Mean salivary CRP value among cases was 3.42±2.786 and among controls was 2.84±0.848. Mean HADS score among cases was 6.60±2.796 and among controls was 2.70±0.948. Mean Salivary CRP and HADS values were higher in OLP patients compared to controls. However, no statistical significant association could be established between CRP and HADS in patients with OLP (p=0.200).
Conclusion: No correlation between psychological status and CRP levels could be established in patients with OLP. CRP could be used as a diagnostic marker in oral premalignant lesions.
Anxiety, Depression, Hospital anxiety and depression scale, Saliva
Date of Submission: Oct 30, 2020
Date of Peer Review: Dec 21, 2020
Date of Acceptance: Mar 31, 2021
Date of Publishing: May 01, 2021
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
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• Plagiarism X-checker: Nov 03, 2020
• Manual Googling: Dec 19, 2020
• iThenticate Software: Apr 29, 2021 (9%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
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- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)