Study on Association of Serum Uric Acid and Calcium with Insulin and its Resistance in Newly Diagnosed Type 2 Diabetes Mellitus PatientsCorrespondence Address :
Dr. Debjyoti Mohapatra,
Plot No. 94/1350, Sub-plot-140, Sainik Nagarkesura,
Postbankuala-751002, Bhubaneswar, Odisha, India.
Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial pathological condition associated with insulin resistance and insulin deficiency. Uric acid and calcium have shown inconsistent association with occurrence of diabetes.
Aim: To evaluate the role of uric acid and calcium in development of T2DM.
Materials and Methods: This was a cross-sectional study comprising of 180 subjects undertaken with the objective of finding any association of serum uric acid and calcium with insulin and its resistance in newly diagnosed T2DM cases. Newly diagnosed T2DM patients were taken as cases. Age and sex matched healthy individuals were taken as controls. Fasting Plasma Glucose (FPG), serum insulin, serum uric acid and ionised calcium were measured in autoanalyser and insulin resistance was calculated using Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Other confounding risk factors for T2DM like Body Mass Index (BMI), family history was taken into account.
Results: A significant positive correlation of serum uric acid with serum insulin (p=0.029) and its resistance (p=0.032) in cases. Serum calcium was negatively associated with insulin and its resistance in both cases and controls. Regression models showed serum uric acid as a strong independent risk factor for levels of insulin and its resistance.
Conclusion: The findings of the study showed that regular evaluation of serum uric acid and calcium should be done in those who are at risk of developing T2DM. Larger prospective studies will be required for definite assessment.
Homeostasis model assessment for insulin resistance, Insulin deficiency, Obesity
Date of Submission: Mar 19, 2021
Date of Peer Review: May 24, 2021
Date of Acceptance: Jul 22, 2021
Date of Publishing: Oct 01, 2021
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
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