Type 2 Diabetes Mellitus- Better Associated with BMI, Abdominal Obesity or Insulin Resistance?
Correspondence Address :
Sreelakshmi Mohanan,
Department of Physiology, KMCT Medical College, Calicut, Kerala, India.
E-mail: sreelakshmiarun2018@gmail.com
Introduction: Type 2 Diabetes Mellitus (T2DM) has emerged as a major public health concern globally and it is associated with a multitude of complications leading to mortality and morbidity. A close association has been observed with T2DM and obesity in various studies, which has been closely associated with intraabdominal or central obesity rather than to overall adiposity.
Aim: To evaluate the association of T2DM with anthropometric parameters, abdominal obesity parameters and Insulin Resistance (IR).
Material and Methods: A case-control study was conducted amongst 64 normal healthy individuals and 64 diabetic patients attending the diabetic clinic of a tertiary care centre over a period of one year. Participants aged between 30 to 75 years were recruited. The abdominal obesity anthropometric parameters which included Body Mass Index (BMI), Waist Circumference (WC), Waist Hip Ratio (WHR), Waist Height Ratio (WHtR) were recorded. IR was estimated using Homeostasis Model Assessment (HOMA)-IR method. Data was entered in Microsoft Excel software and data was analysed using Statistical Package for the Social Sciences (SPSS) software version 16.0.
Results: A 64 T2DM patients and 64 normal healthy controls were included in the study. The mean BMI was 23.1±2.3 and 21.3±1.2 for cases and controls, respectively (p-value <0.001). The mean WC was 84.0±4.8 and 80.5±2.8 (p-value=0.003), and mean WHR was 0.9±0.3 and 0.8±0.02 (p-value <0.001) for cases and controls, respectively. The mean WHtR was 0.5±0.1 and 0.5±0.03 (p-value=0.330), and mean IR was 3.8±1.1 and 1.3±0.2 (p-value <0.001) for cases and controls, respectively. A statistically significant positive correlation was observed between IR and WC of T2DM patients (p-value=0.025). A statistically insignificant positive correlation was observed between IR and BMI (p-value=0.105).
Conclusion: Body Mass Index (BMI), abdominal obesity parameters and IR values were elevated in T2DM. Among the anthropometric parameters studied, WHtR was observed to be a better parameter and it can be used routinely in a clinical setting as it has a constant parameter (height).
Body mass index, Insulin resistance, Waist circumference, Waist height ratio, Waist hip ratio
DOI: 10.7860/JCDR/2021/51487.15749
Date of Submission: Jul 21, 2021
Date of Peer Review: Sep 02, 2021
Date of Acceptance: Nov 20, 2021
Date of Publishing: Dec 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. No
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Jul 21, 2021
• Manual Googling: Oct 13, 2021
• iThenticate Software: Nov 18, 2021 (20%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Embase
- EBSCOhost
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)
- www.omnimedicalsearch.com