A Cross-sectional Study of Antipsychotic Drugs Induced Sexual Dysfunction among Married Males with Remitted Schizophrenia Attending Tertiary Health Care Centre from Central IndiaCorrespondence Address :
Dr. Ajinkya Sureshrao Ghogare,
Assistant Professor, Department of Psychiatry, Jawaharlal Nehru Medical College,
Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi,
Wardha-442001, Maharashtra, India.
Introduction: Schizophrenia is a chronic debilitating disease having a major impact on the sufferers’ lives. Antipsychotic drugs are the mainstay of the treatment of schizophrenia. But, antipsychotics can lead to a variety of sexual dysfunctions among the males with schizophrenia, which may affect their treatment compliance.
Aim: To assess the prevalence and the types of sexual dysfunctions among married males with remitted schizophrenia who were on a single oral antipsychotic drug from either class (i.e., typical or atypical type).
Materials and Methods: The present cross-sectional study was conducted in a tertiary health-care centre from Central India, with a sample size of 100 married males with schizophrenia who were in the remission phase on a single oral antipsychotic drug. Data were collected by using a convenient sampling method. Socio-demographic profile and clinical variables were recorded in a specific case report form prepared for the study using the Arizona Sexual Experiences (ASEX) scale and the Udvalg for Kliniske Undersogelser (UKU) side-effect rating scale to assess the prevalence and the types of oral antipsychotic drugs induced sexual dysfunctions among study participants.
Results: The prevalence of antipsychotic drug induced sexual dysfunction was 54%. The most common type of sexual sideeffect of oral antipsychotic treatment was Decreased Sexual Desire/Drive (DSD) as assessed by both ASEX (94.4%) and UKU (63.0%) scales. Sexual dysfunctions like DSD and Ejaculatory Dysfunction (EJD) were associated with the treatment of schizophrenia with typical antipsychotic drugs.
Conclusion: The present study shows that the treatment with typical antipsychotics was significantly associated with sexual side-effects. So, routine inquiry during the follow-ups should be done regarding the evaluation of sexual side-effects of antipsychotic agents in order to improve treatment compliance and disease prognosis.
Ejaculatory dysfunction, Sexuality, Sexual desire, Treatment compliance, Treatment emergent sexual dysfunctions
Date of Submission: Sep 05, 2020
Date of Peer Review: Oct 29, 2020
Date of Acceptance: Dec 16, 2020
Date of Publishing: Mar 01, 2021
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA
PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Sep 09, 2020
• Manual Googling: Dec 08, 2020
• iThenticate Software: Jan 07, 2021 (14%)
ETYMOLOGY: Author Origin
- Emerging Sources Citation Index (Web of Science, thomsonreuters)
- Index Copernicus ICV 2017: 134.54
- Academic Search Complete Database
- Directory of Open Access Journals (DOAJ)
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Popline (reproductive health literature)