Effect of Convolvulus pluricaulis and Omega-3 Fatty Acid alone and in Combination on Learning and MemoryCorrespondence Address :
Dr. Rajendra Nath,
Department of Pharmacology, King George’s Medical University, Lucknow, Uttar Pradesh, India.
Introduction: Mental disorders contribute to a significant load of morbidity and disability. In neurological disorders alternative medicine use is common due to their fewer side-effects. There are scant evidences regarding the role of Convolvulus pluricaulis (C. pluricaulis) and Omega (?)-3 fatty acids in learning and memory, and none for their combined effect.
Aim: To evaluate the effect of C. pluricaulis alone and in combination with ?-3 fatty acids.
Materials and Methods: The present study was an animal study done on Wistar rats. C. pluricaulis whole plant powder in doses of 100 mg/kg b.w. and 400 mg/kg body weight (b.w.) was used. ?-3 fatty acid (500 mg/kg b.w.) was administered orally alone and along with a higher dose of C. pluricaulis. Scopolamine induced model for amnesia in rats was used in the study and Donepezil was taken as standard. Apart from the behavioural analysis, Acetylcholinesterase (AchE) estimation in rat’s whole brain tissue was done using spectrophotometry.
Results: C. pluricaulis showed significant memory enhancement in a dose dependent manner (100 mg/kg b.w. and 400 mg/kg b.w.) alone and in combination (C. pluricaulis 400 mg/kg b.w.) with ?-3 fatty acid in dose of 500 mg/kg b.w.
Conclusion: The combination of C. pluricaulis and ?-3 fatty acid showed greater significant effect as compared to alone which was comparable to standard drug.The encouraging results reveal the importance of herbal drugs and nutrients in cognition improvement.
Alzheimer’s disease, Cognition, Complementary and alternative medicine, Cook’s pole climbing test, Morris water maze test
Date of Submission: Jun 09, 2021
Date of Peer Review: Sep 01, 2021
Date of Acceptance: Nov 20, 2021
Date of Publishing: Jan 01, 2022
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. NA
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ETYMOLOGY: Author Origin
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