Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
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Consultant
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Aug 2018




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Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
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Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Original article / research
Year : 2022 | Month : December | Volume : 16 | Issue : 12 | Page : DC01 - DC04 Full Version

Analysis of Factors Hindering the Measles Elimination among Children at a Tertiary Care Hospital in South India


Published: December 1, 2022 | DOI: https://doi.org/10.7860/JCDR/2022/59855.17199
Nirmala Cherukuri, Srividya Yeruva, Usha Rani Thota, Karunya Karnabathula

1. Professor, Department of Paediatrics, Niloufer Hospital, Hyderabad, Telangana, India. 2. Assistant Professor, Department of Microbiology, Niloufer Hospital, Hyderabad, Telangana, India. 3. Professor and Head, Department of Paediatrics, Niloufer Hospital, Hyderabad, Telangana, India. 4. Postgraduate Student, Department of Paediatrics, Niloufer Hospital, Hyderabad, Telangana, India.

Correspondence Address :
Srividya Yeruva,
Flat No. 106, Jaganatha Residency, Besides Apollo Hospital, Hyderguda, Hyderabad, Telangana, India.
E-mail: drsrividya84@gmail.com

Abstract

Introduction: Measles is a highly infectious acute viral disease that can lead to serious complications and death. Effective immunisation coverage for measles will play a pivotal role in its elimination strategy. So, the global commitment, strengthening of health infrastructure and effective vaccine coverage are essential to achieve a world that will be free of measles.

Aim: To assess the factors associated with the occurrence of measles and to determine the factors responsible for non compliance to measles vaccination.

Materials and Methods: A cross-sectional study was conducted in the Department of Paediatrics at Niloufer Hospital, Hyderabad, India, during the period from October 2019 to March 2020 among the children clinical diagnosed with measles. The patients were evaluated for fever, rash, respiratory and other clinical symptoms associated with measles. History of measles vaccination and vitamin A administration were taken. Blood samples of patients were collected and measles specific IgM antibody detection test was done by Enzyme-linked Immunosorbent Assay (ELISA). Data was statistically analysed and presented as numbers and percentages were calculated.

Results: Among 129 children, clinically diagnosed with measles, the predominant age group of children affected was 1-6 years 68 (52.71%). Overall, 38 (29.5%) were vaccinated and 85 (65.9%) were unvaccinated during routine immunisation schedule. Measles-Containing Vaccine (MCV) coverage during Supplementary Immunisation Activities (SIAs) was also very limited (19.3%). Out of 129 cases, 121 (93.7%) were confirmed positive by measles IgM ELISA, 5 (3.8%) samples gave equivocal results and 3 (2.3%) were negative for the test.

Conclusion: Inspite of the availability of effective and inexpensive measles vaccine for decades, vaccination coverage remains inadequate across the globe. So, effective implementation of vaccine services and monitoring of its surveillance system are needed for eradication of measles.

Keywords

Enzyme-linked immunosorbent assay, Rash, Supplementary immunisation activities, Vaccination, Vitamin A

Measles, a febrile illness can cause serious complications and death. It is one of the world’s most contagious viral diseases (1). In 2018, worldwide, more than 140000 people died from measles despite of the safe and cost-effective vaccine, mostly among children under the age of five. World Health Organisation (WHO) accelerated immunisation activities to decrease measles-related morbidity and mortality since 2000 (2). Though, measles burden is not completely reduced due to gaps in immunisation, they saved millions of lives by preventing life-threatening complications such as bronchopneumonia and subacute sclerosing panencephalitis by giving momentum to the measles elimination programme. The world has taken the oath to eliminate measles in almost all the WHO regions by 2020 (3),(4), which still remained unaccomplished may be due to inadequate vaccine delivery system to provide measles vaccine properly to persons in need and measles immunisation with single-dose has been unsuccessful in eliminating measles.

Vaccine failures due to interference of maternal antibody may be primary cause of continued circulation of the virus. Improved protection afforded by two doses of measles vaccine is well-documented in many countries where two-dose schedules have been implemented strictly for years (5). So, missing second dose may be one of the reasons for vaccine failure. Eradication of measles is feasible because of the presence of several key elements, including humans as the only reservoir for the virus, wide access to diagnostic facilities that can rapidly detect measles-infectious persons and availability of highly safe and effective Measles-Containing Vaccines (MCVs). One of the major complications of measles is pneumonia. Measles is particularly dangerous in children with vitamin A deficiency. Various studies found that vitamin A megadoses (200,000 international units) on each day for two days lowered the number of deaths from measles in hospitalised children with pneumonia under the age of two years. Two doses of vitamin A are not too expensive, and are not likely to produce adverse effects (6).

Global commitment to establishment of good public health infrastructure and implementing policies that can overcome access barriers and enhance vaccine coverage is very much essential to achieve a world free of measles (1). To assess the factors associated with the occurrence of measles and to determine the factors responsible for non compliance to measles vaccination.

Material and Methods

A cross-sectional prospective study was conducted in the Department of Paediatrics, Niloufer Hospital, Hyderabad, India. Consecutive child aged one month to 12 years with clinical history suspected of measles admitted to the Department of Paediatrics for a period of six months from October 2019 to March 2020 were enrolled in the study. This study was approved by Institutional Ethical Committee (IEC/OMC/M.NO.50 (ACAD)/77). Written informed consent was taken from each case included in the study.

Inclusion criteria: All the children aged one month to 12 years with history of fever, rash and respiratory symptoms suggestive of clinical measles of both sexes admitted to the Department of Paediatrics, during the study period was included in the present study.

Exclusion criteria: Children with dengue, Epstein-Barr virus infection, children with rash and jaundice and other exanthematous illnesses not suggestive of measles and those who did not give consent were excluded from the study.

Study Procedure

All 129 children were physically examined and detailed history was collected from patients and also from their medical records regarding their clinical symptoms, past clinical history, measles vaccination status-whether the vaccine was taken or not, the number of measles vaccine doses received, the reasons for not taking the vaccine, the status of mass Measles-Rubella (MR) vaccination campaigns conducted in their vicinity, history of vitamin A supplementation. The investigations and treatment were carried out as per the Institution’s protocol. Blood samples were collected from all the children clinically suspected of measles and serum was separated and tested for measles-specific IgM antibody detection by Enzyme-linked Immunosorbent Assay (ELISA) according to the manufacturer’s instructions. These tests used Enzygnost, Anti-measles Indirect ELISA kit (Siemens), with the amount of blood needed for each test being 3-5 mL, and the interpretation of the results were as follows:

>0.3=positive,
<0.2=negative, and
0.2 to <0.3=equivocal.

IgM ELISA detection is most sensitive 4-28 days after the rash onset (7). Laboratory results and outcomes of all those children were obtained and the results were analysed.

Statistical Analysis

Descriptive statistical analysis was done and data was presented as numbers and percentages were calculated.

Results

Demographic details like age, gender distribution and detailed history of rural, urban background, religion and vitamin A supplementation among 129 study participants is shown in (Table/Fig 1). Among 129 measles cases in the present study, majority affected were males 76 (58.91%) and 1-6 years age group children 68 (52.71%). Measles cases were predominantly seen among children from urban areas 115 (89.14%) than that of rural.

District wise distribution of measles cases in the present study is shown in (Table/Fig 2). Maximum number of measles cases in Telangana are from Hyderabad (86 cases) and Ranga Reddy district (20 cases). Clinical presentations of 129 measles cases in the present study is shown in (Table/Fig 3). Fever 129 (100%) and maculopapular rash 128 (99.2%) were seen in almost all the cases. Among 129 study participants, 85 (65.9%) were unvaccinated with MCV1 and 89 (68.9%) remained unvaccinated with MCV2. Overall 85 (65.9%) children did not receive, even single dose of measles vaccine (Table/Fig 4).

Measles IgM ELISA was performed on blood samples of 129 clinically suspected measles cases. Test gave 5 (3.8%) equivocal and 3 (2.3%) negative results. This may be due to early sample collection before production of IgM antibodies in patients body (Table/Fig 5).

Discussion

Measles can affect the children under the age of five years most commonly. It is a highly infectious viral illness associated with fever and rash which may lead to serious complications like pneumonia and encephalitis, that may lead to death (8). The transmission of Measles Virus (MeV) infection is mainly by aerosolised secretions found on upper respiratory tract mucosal surfaces. Although large proportions of the Measle disease cases are self-limiting still mortality rates are high (9). Measles is persistently endemic in advanced, developing and underdeveloped countries in spite of the availability of vaccine for over many years (8). In the year 2015, India accounted for over one-third of measles deaths and was included in the global campaign for elimination by the year 2020. Immunisation campaigns for all children aged nine months to 15 years and case-based surveillance are part of the elimination strategy (10). Implementation of key strategies like sensitisation of front-line workers, increasing search for active cases, reporting network expansion, rapid response to outbreaks and establishing harmonious linkages between measles elimination and other public health issues, such as health systems strengthening and emergency preparedness and response. Collaborations between the Governments, partners and the community at every level to clear immunity gaps is important. WHO-National Polio Surveillance Project teams have supported the Government of India in strengthening MR surveillance system and immunisation across states and union territories to attain and maintain high population immunity. This is pivotal for elimination. India has done it before. India will do it again (2).

In the present study, 68 children in the age group of 1-6 years were significantly affected by measles (52.71%) followed by infants 55 (42.63%) compared to older children. The findings were comparable with the studies by Husada D et al., and Kumari PL and Kutty AM (7),(11) with 60% and 38.3% of measles-affected children highest between 1-6 years. In contrast, older children i.e, 6-12 years (44.8%) and infants (41.4%) were more commonly affected in Sindhu TG et al., study (10). In this study, majority of cases were boys 76 (58.91%) which was in accordance with various other studies (8),(9),(10). About 89% of measles cases in current study were urban population, it may be because in recent times people living in urban slum areas have increased rapidly and immunisation coverage and living conditions in poor urban communities are low compared to people living in rural areas. But, today even the occurrence of measles can be easily found in rural areas and with lower socio-economic class (11). It is hypothesised that vitamin A deficiency is a risk factor for severe measles infection in children, so the administration of vitamin A reduces the risk of complications from measles (12). In present study, 52.71% of children received vitamin A along with the measles vaccine. In comparison more children, around 84% received vitamin A in Husada D et al., study (7), implicating the need for improving the coverage of vitamin A in authors’ area. Fever (100%), maculopapular rash (99.2%) are the most common clinical presentations of measles cases in the present study which is in accordance with the study by Husada D et al., (7). In contrast, in Hirfanoglu T et al., cough (97.5%) and conjunctivitis (72.2%) were the most common clinical presentations in measles cases (13). In a study, by Bhowmik E et al., the fever (38%) was found to be most common symptom followed by rashes (14).

Measles is endemic in many countries in spite of the availability of vaccine for over 60 years. Immunisation with two-dose of vaccine was introduced in India in 2010. The protection level varies from person to person and also the antibody levels decrease over time so immunisation with two doses will help in combating this problem. The important obstacle to the elimination of measles is suboptimal immunisation in both developing and developed countries, parental resistance to vaccination, doubts about the protective efficacy of the vaccine, problems with the cold chain or vaccine administration and movement of the people between endemic and non endemic places (8).

In present study, 38 (29.5%) measles cases received atleast a single dose of measles vaccine, 85 (65.9%) were unvaccinated and the vaccination history of 6 (4.7%) remains unknown. It is in accordance with Sowe A et al., study (15) in which more than half (53.6%) of the confirmed cases have unknown vaccination status, 24% of cases were vaccinated and in Husada D et al., study (7) majority of measles cases were unvaccinated 64 (85.3%). The second dose of measles vaccine (MCV2) coverage in the current study was very low (15.5%). The MCV2 increases immunity in children who have not received MCV1 and protect those who did not seroconvert after the first dose. In studies of revaccination among preschool children, who did not develop immunity after the first dose, nearly 95% of them were found to develop protective immunity after the second dose. Two-dose vaccination coverage is most important to prevent measles transmission (16). MCV coverage during SIAs in the present study, was only 19.3% approximately. Though, measles vaccine coverage by SIA can attain higher coverage than routine immunisation, countries with weaker health systems have rarely approached the levels that would be needed to eliminate it. So, vaccination programs should be more frequently and effectively conducted to improve vaccine coverage (17).

In the present study IgM ELISA was performed on blood samples of 129 suspected measles cases, 121 (93.7%) cases were positive for IgM, 5 (3.8%) gave equivocal results and 3 (2.3%) were negative for IgM. According to WHO, 30% of measles cases may show anti-measles IgM test results negative if the blood tests were performed, as early as the third day since the first symptom appeared because IgM antibodies may have not been established by that time. If the blood tests were performed later that is, when the samples were taken on the seventh day of illness, all cases (100%) showed positive results (7).

Limitation(s)

The day of blood sample collection for IgM antibody testing is very important for an accurate laboratory diagnosis of measles. Samples collected as early as third day, may give equivocal or false negative results, even in clinically evident measles cases.

Conclusion

The study concluded that, low and ineffective vaccination coverage was the key factor that is hindering measles elimination. Proper implementations of immunisation programme and measles preventive strategies are essential to achieve the goal of measles elimination, at the earliest. Long-term follow-up studies are needed for getting insight into obstacles in the path of measles prevention and eradication.

Acknowledgement

Authors are thankful to Head of the Department of Paediatrics, Niloufer Hospital, and all the faculty, residents and laboratory personnel for their contribution in providing care to the patients involved in the study and for their help and inputs given for the present study.

References

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Gastanaduy PA, Goodson JL, Panagiotakopoulos L, Rota PA, Orenstein WA, Patel M. Measles in the 21st century: Progress toward achieving and sustaining elimination. J infect Dis. 2021;224(S4):S420-28. [crossref] [PubMed]
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Measles. Accessed on 05 Dec 2019. Available online: https://www.who.int/news-room/fact-sheets/detail/measles.
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World Health Organization. Framework for verifying elimination of measles and rubella. Wkly Epidemiol Rec. 2013;88:89-100.
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Bavdekar SB, Karande S. Elimination of measles from India: Challenges ahead and the way forward. J Postgrad Med. 2017;63(2):75-78. [crossref] [PubMed]
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DOI and Others

DOI: 10.7860/JCDR/2022/59855.17199

Date of Submission: Aug 25, 2022
Date of Peer Review: Oct 06, 2022
Date of Acceptance: Nov 16, 2022
Date of Publishing: Dec 01, 2022

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA

PLAGIARISM CHECKING METHODS:
• Plagiarism X-checker: Sep12, 2022
• Manual Googling: Sep 23, 2022
• iThenticate Software: Nov 14, 2022 (22%)

ETYMOLOGY: Author Origin

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