Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 59069

AbstractCase ReportDiscussionConclusionReferencesDOI and Others
Article in PDF How to Cite Citation Manager Readers' Comments (0) Audio Visual Article Statistics Link to PUBMED Print this Article Send to a Friend
Advertisers Access Statistics Resources

Dr Mohan Z Mani

"Thank you very much for having published my article in record time.I would like to compliment you and your entire staff for your promptness, courtesy, and willingness to be customer friendly, which is quite unusual.I was given your reference by a colleague in pathology,and was able to directly phone your editorial office for clarifications.I would particularly like to thank the publication managers and the Assistant Editor who were following up my article. I would also like to thank you for adjusting the money I paid initially into payment for my modified article,and refunding the balance.
I wish all success to your journal and look forward to sending you any suitable similar article in future"

Dr Mohan Z Mani,
Professor & Head,
Department of Dermatolgy,
Believers Church Medical College,
Thiruvalla, Kerala
On Sep 2018

Prof. Somashekhar Nimbalkar

"Over the last few years, we have published our research regularly in Journal of Clinical and Diagnostic Research. Having published in more than 20 high impact journals over the last five years including several high impact ones and reviewing articles for even more journals across my fields of interest, we value our published work in JCDR for their high standards in publishing scientific articles. The ease of submission, the rapid reviews in under a month, the high quality of their reviewers and keen attention to the final process of proofs and publication, ensure that there are no mistakes in the final article. We have been asked clarifications on several occasions and have been happy to provide them and it exemplifies the commitment to quality of the team at JCDR."

Prof. Somashekhar Nimbalkar
Head, Department of Pediatrics, Pramukhswami Medical College, Karamsad
Chairman, Research Group, Charutar Arogya Mandal, Karamsad
National Joint Coordinator - Advanced IAP NNF NRP Program
Ex-Member, Governing Body, National Neonatology Forum, New Delhi
Ex-President - National Neonatology Forum Gujarat State Chapter
Department of Pediatrics, Pramukhswami Medical College, Karamsad, Anand, Gujarat.
On Sep 2018

Dr. Kalyani R

"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."

Dr Kalyani R
Professor and Head
Department of Pathology
Sri Devaraj Urs Medical College
Sri Devaraj Urs Academy of Higher Education and Research , Kolar, Karnataka
On Sep 2018

Dr. Saumya Navit

"As a peer-reviewed journal, the Journal of Clinical and Diagnostic Research provides an opportunity to researchers, scientists and budding professionals to explore the developments in the field of medicine and dentistry and their varied specialities, thus extending our view on biological diversities of living species in relation to medicine.
‘Knowledge is treasure of a wise man.’ The free access of this journal provides an immense scope of learning for the both the old and the young in field of medicine and dentistry as well. The multidisciplinary nature of the journal makes it a better platform to absorb all that is being researched and developed. The publication process is systematic and professional. Online submission, publication and peer reviewing makes it a user-friendly journal.
As an experienced dentist and an academician, I proudly recommend this journal to the dental fraternity as a good quality open access platform for rapid communication of their cutting-edge research progress and discovery.
I wish JCDR a great success and I hope that journal will soar higher with the passing time."

Dr Saumya Navit
Professor and Head
Department of Pediatric Dentistry
Saraswati Dental College
On Sep 2018

Dr. Arunava Biswas

"My sincere attachment with JCDR as an author as well as reviewer is a learning experience . Their systematic approach in publication of article in various categories is really praiseworthy.
Their prompt and timely response to review's query and the manner in which they have set the reviewing process helps in extracting the best possible scientific writings for publication.
It's a honour and pride to be a part of the JCDR team. My very best wishes to JCDR and hope it will sparkle up above the sky as a high indexed journal in near future."

Dr. Arunava Biswas
MD, DM (Clinical Pharmacology)
Assistant Professor
Department of Pharmacology
Calcutta National Medical College & Hospital , Kolkata

Dr. C.S. Ramesh Babu
" Journal of Clinical and Diagnostic Research (JCDR) is a multi-specialty medical and dental journal publishing high quality research articles in almost all branches of medicine. The quality of printing of figures and tables is excellent and comparable to any International journal. An added advantage is nominal publication charges and monthly issue of the journal and more chances of an article being accepted for publication. Moreover being a multi-specialty journal an article concerning a particular specialty has a wider reach of readers of other related specialties also. As an author and reviewer for several years I find this Journal most suitable and highly recommend this Journal."
Best regards,
C.S. Ramesh Babu,
Associate Professor of Anatomy,
Muzaffarnagar Medical College,
On Aug 2018

Dr. Arundhathi. S
"Journal of Clinical and Diagnostic Research (JCDR) is a reputed peer reviewed journal and is constantly involved in publishing high quality research articles related to medicine. Its been a great pleasure to be associated with this esteemed journal as a reviewer and as an author for a couple of years. The editorial board consists of many dedicated and reputed experts as its members and they are doing an appreciable work in guiding budding researchers. JCDR is doing a commendable job in scientific research by promoting excellent quality research & review articles and case reports & series. The reviewers provide appropriate suggestions that improve the quality of articles. I strongly recommend my fraternity to encourage JCDR by contributing their valuable research work in this widely accepted, user friendly journal. I hope my collaboration with JCDR will continue for a long time".

Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
On Aug 2018

Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
The journal has a monthly publication and the articles are published quite fast. In time compared to other journals. The on-line first publication is also a great advantage and facility to review one's own articles before going to print. The response to any query and permission if required, is quite fast; this is quite commendable. I have a very good experience about seeking quick permission for quoting a photograph (Fig.) from a JCDR article for my chapter authored in an E book. I never thought it would be so easy. No hassles.
Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".

Dr. Mamta Gupta
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018

Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.

Authors are the souls of any journal, and deserve much respect. To publish a journal manuscripts are needed from authors. Authors have a great responsibility for producing facts of their work in terms of number and results truthfully and an individual honesty is expected from authors in this regards. Both ways its true "No authors-No manuscripts-No journals" and "No journals–No manuscripts–No authors". Reviewing a manuscript is also a very responsible and important task of any peer-reviewed journal and to be taken seriously. It needs knowledge on the subject, sincerity, honesty and determination. Although the process of reviewing a manuscript is a time consuming task butit is expected to give one's best remarks within the time frame of the journal.
Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
Timely publication of journal: Publication of manuscripts and bringing out the issue in time is one of the positive aspects of JCDR and is possible with strong support team in terms of peer reviewers, proof reading, language check, computer operators, etc. This is one of the great reasons for authors to submit their work with JCDR. Another best part of JCDR is "Online first Publications" facilities available for the authors. This facility not only provides the prompt publications of the manuscripts but at the same time also early availability of the manuscripts for the readers.
Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
It is well said that "happy beginning is half done" and it fits perfectly with JCDR. It has grown considerably and I feel it has already grown up from its infancy to adolescence, achieving the status of standard online e-journal form Indian continent since its inception in Feb 2007. This had been made possible due to the efforts and the hard work put in it. The way the JCDR is improving with every new volume, with good quality original manuscripts, makes it a quality journal for readers. I must thank and congratulate Dr Hemant Jain, Editor-in-Chief JCDR and his team for their sincere efforts, dedication, and determination for making JCDR a fast growing journal.
Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."

Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Case Series
Year : 2022 | Month : March | Volume : 16 | Issue : 3 | Page : OR01 - OR03 Full Version

Clinical Evaluation of Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease- A Case Series

Published: March 1, 2022 | DOI:
Rahul Gupta, Ramji Sharma, Deepali Sharma

1. Assistant Professor, Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India. 2. Assistant Professor, Department of Internal Medicine, SMS Medical College, Jaipur, Rajasthan, India. 3. Senior Resident, Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.

Correspondence Address :
Dr. Rahul Gupta,
House No.-79/06 Shipra Path, Mansarovar, Jaipur, Rajasthan, India.


In recent years, there has been lot of research on Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) associated disease. It’s clinical phenotype overlaps with Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMOSD), however many questions related to clinical characteristics and pathogenetic role of MOG antibody is still unanswered. Hereby, authors report a case series of nine patients (five females and four males), describing their seropositivity for MOG antibody and clinical characteristics of MOG antibody associated disease. The clinical presentation, radiology, acute treatment and long term management were analysed. The most common presentation was optic neuritis followed by Longitudinally Extensive Transverse Myelitis (LETM). Tab. Azathioprine was most commonly used medicine for disease modifying therapy (long term immunosuppression). The attacks are more severe than MS but recovery is better than antibodies to Aquaporin-4 (AQP4-IgG) seropositive NMOSD.


Demyelinating, Multiple sclerosis, Neuromyelitis optica spectrum disorder

In recent years, there has been lot of research on Myelin Oligodendrocyte Glycoprotein Antibody (MOG-IgG) associated disease. Before the cell-based assay transfected with MOG in its conformational form, MOG-IgG were a biomarker of Multiple Sclerosis (MS) (1). MOG-antibody disease is a separate spectrum of Central Nervous System (CNS) inflammatory demyelinating disease distinct from MS and antibodies to Aquaporin-4 (AQP4-IgG)-seropositive Neuromyelitis optica spectrum disorder (NMOSD) (1).

Myelin oligodendrocyte glycoprotein is a protein expressed over mammalian oligodendrocytes and can elicit demyelinating immune response (2). The clinical manifestations occur similar to other CNS inflammatory demyelinating diseases. The slight female predominance was reported in the largest clinical series (3). Preceding prodormal symptoms suggesting infection can occur. The major clinical manifestations are optic neuritis, Longitudinally Extensive Transverse Myelitis (LETM), Acute Disseminated Encephalomyelitis (ADEM) and brainstem demyelinating episode (1). In paediatric population, ADEM is more common (4). The episodes are more severe than MS but better recovery than AQP4-IgG-seropositive NMOSD (1).

When classical phenotype of MOG-IgG disease is suspected, antibody testing should be advised. Testing with cell-based assay should be advised and other methodology like Enzyme Linked Immunosorbent Assay (ELISA), western blot or assay using non conformational MOG epitope should be avoided (5).

Case Report

In the present case series, nine cases presented with CNS demyelinating disease and found positive for MOG antibody and seronegative for AQP4-IgG were included in the study. The patients included were from admitted patients of Department of Neurology or referred patients from Department of Medicine of Sawai Man Singh hospital, Jaipur, Rajasthan, India. In all patients, cell-based assay for both MOG-IgG and AQP4-IgG was advised. Four patients were male and five were females. The patients were adolescents or adults age group with range from 12 to 40 years and mean age of patients was 27.8 years. The most common presentation was optic neuritis followed by LETM. The clinical characteristics of patients, Magnetic Resonance Imaging (MRI) brain and spine, Visual Evoked Potential (VEP), Cerebrospinal Fluid (CSF) findings, acute treatment given, disease modifying treatment, follow-up and recurrences were given in (Table/Fig 1), (Table/Fig 2).


According to previous literature, MOG antibody associated disease accounts for 1.2 to 6.5% cases among all demyelinating syndromes in adults (6). In previous studies, optic neuritis was the most common presentation (6),(7),(8). Acute disseminated encephalomyelitis is the most common manifestation of Myelin oligodendrocyte glycoprotein antibody-associated disease among <18 years age group (9). Brain MRI can be abnormal among 50% of cases, regardless of clinical presentation (7). In optic nerve, anterior part in intraorbital region is described to be most commonly involved while in MRI spine, LETM is the most common presentation but short segment myelitis can be seen in 40% of cases (7).

Out of nine cases, five were females and four were males. Mean age of patients was 27.8 years. This observation is similar to previous literature in which slight female predominance was reported. Similarly, children and young adults are the age groups, commonly affected (3). The most common presentation was optic neuritis (n=6) in our series as reported in other studies. It was unilateral in five and bilateral in one case (case 8). Though bilateral optic neuritis was seen in one case (case 8), VEP was prolonged or absent in both eyes in five patients, one of these patient (case 7) did not have ocular symptoms. In previous studies, optic neuritis is present in upto 80% patients either on presentation or during course while forty percentages of patients have simultaneous involvement of both eyes (7). In another study, Lee YJ et al., described optic neuritis was the major phenotype (41-63%) (9). Brayo P et al., in their series reported optic neuritis in 81% (nine out of 11 cases), it was bilateral in six while unilateral in three cases (8). The other clinical manifestations in the present study were LETM and cranial nerve palsies other than optic nerve. LETM was observed in four cases and cranial nerve involvement was seen in one case (case 7). Simultaneous optic neuritis with LETM was observed in one case (case 1). In LETM most common involved part was thoracic cord followed by cervical cord. In previous study, spinal cord involvement is seen in 30% cases during presentation and 50% during course (7). In another case series, it was seen in 18% of cases (8). The recurrence of symptoms was seen in one case (case 4). This patient was having two episodes of optic neuritis and that was before presenting to us. This case didn’t have recurrence after starting immunosuppressive medication. The proportion of patients with a single attack is likely reduced with long-term follow-up (9),(10). In case series by Brayo P et al., it was seen in 64% of cases (8). The lower recurrence in present case may be due to lower duration (6-12 months) of follow-up. None of the patient developed ADEM like presentation, which was more commonly observed in paediatric age group (4),(9).

Visual evoked potential was abnormal in seven patients. It was abnormal bilaterally in five patients. Four of these patients were having symptoms only in one eye. In present case, one of the patients (case 7) didn’t have ocular symptoms but abnormal VEP in both eyes. In MRI of brain with orbit the most common pattern was involvement of anterior part (intraorbital part) of optic nerve. This was in accordance to previous literature in which MOG antibody disease have predilection to involvement of anterior part while NMOSD tends to involve posterior part of optic nerve or optic chiasma (4). Only two patients (case 6, 7) had involvement of white matter in MRI brain in subcortical location and brainstem in the present series. The lesions were large in size as opposed to smaller lesions in MS (Table/Fig 2)a and (Table/Fig 2)b. In MRI spine involvement of gray matter was common forming axial H sign. In the literature involvement of central gray matter is shown more than white matter in MOG differing it from NMOSD where both gray and white matter typically involve (11).

In 2018 consensus, it has been outlined that MOG antibody should be advised in those patients who presented with one of the classical phenotypes of MOG disease and lack the characteristic of MS. In low probability situation, false positive cases may occur (12). The testing should be done with one of the cell based assay from blood (12). In literature, few cases are described having co-existent AQP4-IgG and MOG antibody (6). Hence, in current case series those patients were selected in which both MOG-IgG and AQP4-IgG were advised and only MOG was positive.

No randomised clinical trials are available to guide treatment for MOG antibody disease; hence, it is largely adopted from management of seropositive NMOSD cases. In acute situation, it has been suggested to use 500-2000 mg i.v. MPs (Intravenous methylprednisolones) for 3-7 days and plasma exchange is reserved for non responders (13),(14). MOG antibody associated disease is a steroid-responsive condition, and a proportion of patients have early relapses during rapid steroid tapers or shortly after cessation (15). In our setting, all nine cases received i.v. MPs for 5 days. Six patients showed improvement with i.v. MPs. Three case were not responsive to steroid were offered five cycle plasma exchange on alternative day. At the end of six months, two patients were having residual paresis of limbs while one patient was having incomplete vision recovery.

Disease modifying treatment used in previous studies was monthly injection of i.v. IG, rituximab, mycophenolate mofetil, methotrexate and azathioprine (7),(8),(13). There is no consensus about what to use and the duration till when to use. Authors started tab. azathioprine as long term immunosuppressive in six of the presented patients. Three patients with milder presentation or very rapid improvement on methylprednisolone were closely watched. Till now, there are no recurrences at end of 6-12 months of follow-up.


In recent years, a number of immune targets for central nervous system inflammatory demyelinating disease have been identified. MOG antibody disease has become a clear disease entity separated itself from MS and seropositive NMOSD not only from clinico-radiological pattern but also from long term outcome. In the study centre, the authors tested all patients of CNS demyelinating disease with MOG in whom radiology differs from MS. More prospective study and randomised trial are required to better guide for management of MOG antibody disease.


Reindl M, Jarius S, Rostasy K, Berger T. Myelin oligodendrocyte glycoprotein antibodies: How clinically useful are they? Curr Opin Neurol. 2017;30(3):295-301. Doi: 10.1097/WCO.0000000000000446. PMID: 28248700. [crossref] [PubMed]
Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol. 2019;15(2):89-102. Doi: 10.1038/s41582-018-0112-x. PMID: 30559466. [crossref] [PubMed]
Jurynczyk M, Messina S, Woodhall MR, Raza N, Everett R, Roca-Fernandez A, et al. Clinical presentation and prognosis in MOG-antibody disease: A UK study. Brain. 2017;140(12):3128-38. Doi: 10.1093/brain/awx276. Erratum in: Brain. 2018 Apr 1;141(4):e31. PMID: 29136091. [crossref] [PubMed]
Juryn´??czyk M, Jacob A, Fujihara K, Palace J. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: Practical considerations. Pract Neurol. 2019;19(3):187-95. Doi: 10.1136/practneurol-2017-001787. Epub 2018 Dec 8. PMID: 30530724. [crossref] [PubMed]
Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili KI, et al. MOG-IgG in NMO and related disorders: A multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. J Neuroinflammation. 2016;13(1):279. [crossref] [PubMed]
Kunchok A, Chen JJ, McKeon A, Mills JR, Flanagan EP, Pittock SJ. Co-existence of myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies in adult and paediatric patients. JAMA Neurol. 2020;77(2):257-59. [crossref] [PubMed]
Marignier R, Hacohen Y, Cobo-Calvo A, Pröbstel AK, Aktas O, Alexopoulos H, et al. Myelin-oligodendrocyte glycoprotein antibody-associated disease. Lancet Neurol. 2021;20(9):762-72. [crossref]
Brayo P, Hartsell FL, Skeen M, Morgenlander J, Eckstein C, Shah S. The clinical presentation and treatment of MOG antibody disease at a single academic center: A case series. J Neuroimmunol. 2019;337:577078. Doi: 10.1016/j.jneuroim.2019.577078. Epub 2019 Oct 15. PMID: 31671362. [crossref] [PubMed]
Lee YJ, Nam SO, Ko A, Kong J, Byun SY. Myelin oligodendrocyte glycoprotein antibody-associated disorders: Clinical spectrum, diagnostic evaluation, and treatment options. Clin Exp Paediatr. 2021;64(3):103-10. Doi: 10.3345/cep.2019.01305. Epub 2020 May 14. PMID: 32403899; PMCID: PMC7940088. [crossref] [PubMed]
Sepúlveda M, Armangue T, Martinez-Hernandez E, Arrambide G, Sola-Valls N, Sabater L, et al. Clinical spectrum associated with MOG autoimmunity in adults: Significance of sharing rodent MOG epitopes. J Neurol. 2016;263(7):1349-60. [crossref] [PubMed]
Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, et al. Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody. JAMA Neurol. 2019;76(3):301-09. Doi: 10.1001/jamaneurol.2018.4053. PMID: 30575890; PMCID: PMC6440233. [crossref] [PubMed]
Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J, et al. MOG encephalomyelitis: International recommendations on diagnosis and antibody testing. J Neuroinflammation. 2018;15(1):134. Doi: 10.1186/s12974-018-1144-2. PMID: 29724224; PMCID: PMC5932838. [crossref] [PubMed]
Wynford-Thomas R, Jacob A, Tomassini V. Neurological update: MOG antibody disease. J Neurol. 2019;266(5):1280-86. [crossref] [PubMed]
National Institute for Health and Care Excellence Multiple Sclerosis: Management of Multiple Sclerosis in Primary and Secondary Care. [(accessed on 3 December 2019)]; Available online:
Dale RC, Ramanathan S. Clinical decision making in MOG antibody-associated disease. The Lancet Neurology. 2021;20(9):695-97. Doi: 10.1016/s1474-4422(21)00247-7. [crossref]

DOI and Others

DOI: 10.7860/JCDR/2022/54943.16178

Date of Submission: Jan 13, 2022
Date of Peer Review: Jan 21, 2022
Date of Acceptance: Feb 08, 2022
Date of Publishing: Mar 01, 2022

• Financial or Other Competing Interests: None
• Was informed consent obtained from the subjects involved in the study? NA
• For any images presented appropriate consent has been obtained from the subjects. Yes

• Plagiarism X-checker: Jan 15, 2021
• Manual Googling: Feb 05, 2022
• iThenticate Software: Feb 24, 2022 (5%)

Etymology: Author Origin

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2017: 134.54
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • Embase
  • EBSCOhost
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)