Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018




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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."



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On Aug 2018




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Dr. Arundhathi. S
MBBS, MD (Pathology),
Sanjay Gandhi institute of trauma and orthopedics,
Bengaluru.
On Aug 2018




Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
It 's a multispecialty journal, publishing high quality articles. It gives a platform to the authors to publish their research work which can be available for everyone across the globe to read. The best thing about JCDR is that the full articles of all medical specialties are available as pdf/html for reading free of cost or without institutional subscription, which is not there for other journals. For those who have problem in writing manuscript or do statistical work, JCDR comes for their rescue.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
My best wishes to Dr. Hemant Jain and all the editorial staff of JCDR for their untiring efforts to bring out this journal. I strongly recommend medical fraternity to publish their valuable research work in this esteemed journal, JCDR".



Dr. Mamta Gupta
Consultant
(Ex HOD Obs &Gynae, Hindu Rao Hospital and associated NDMC Medical College, Delhi)
Aug 2018




Dr. Rajendra Kumar Ghritlaharey

"I wish to thank Dr. Hemant Jain, Editor-in-Chief Journal of Clinical and Diagnostic Research (JCDR), for asking me to write up few words.
Writing is the representation of language in a textual medium i e; into the words and sentences on paper. Quality medical manuscript writing in particular, demands not only a high-quality research, but also requires accurate and concise communication of findings and conclusions, with adherence to particular journal guidelines. In medical field whether working in teaching, private, or in corporate institution, everyone wants to excel in his / her own field and get recognised by making manuscripts publication.


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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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Indexation and online availability: Indexation transforms the journal in some sense from its local ownership to the worldwide professional community and to the public.JCDR is indexed with Embase & EMbiology, Google Scholar, Index Copernicus, Chemical Abstracts Service, Journal seek Database, Indian Science Abstracts, to name few of them. Manuscriptspublished in JCDR are available on major search engines ie; google, yahoo, msn.
In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
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Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."



Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
E-mail: drrajendrak1@rediffmail.com
On May 11,2011




Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."



Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
E-mail: ravi.dr.shankar@gmail.com
On April 2011
Anuradha

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.


Dr. Anuradha
E-mail: anuradha2nittur@gmail.com
On Jan 2020

Important Notice

Original article / research
Year : 2022 | Month : March | Volume : 16 | Issue : 3 | Page : SC06 - SC10 Full Version

Clinical Profile and Short Term Outcome of Acute Encephalitis Syndrome in Children: An Observational Study from a Tertiary Care Centre, Tripura, India


Published: March 1, 2022 | DOI: https://doi.org/10.7860/JCDR/2022/51692.16111
Sujit Kumar Chakrabarti, Sribas Das, Prasenjit Das, Sanjib Kumar Debbarma

1. Associate Professor, Department of Paediatrics, Agartala Government Medical College, Agartala, Tripura, India. 2. Assistant Professor, Department of Paediatrics, Agartala Government Medical College, Agartala, Tripura, India. 3. Resident, Department of Paediatrics, Agartala Government Medical College, Agartala, Tripura, India. 4. Professor, Department of Paediatrics, Agartala Government Medical College, Agartala, Tripura, India.

Correspondence Address :
Dr. Sribas Das,
Assistant Professor, Department of Paediatrics, Agartala Government Medical College,
PO: Kunjavan, Agartala-799006, Tripura, India.
E-mail: drsribas70@gmail.com

Abstract

Introduction: Acute Encephalitis Syndrome (AES) is a group of neurologic manifestation caused by wide range of microbes, chemicals and toxins. Japanese Encephalitis Virus (JEV) is the major cause of AES in India. Isolation of aetiological agent in AES cases presents a fundamental challenge to prevention and management. Lack of study on AES in the paediatric population of Tripura prompted the authors to take up this study.

Aim: To determine the clinical profile and short term outcome of children with AES from Tripura, India.

Materials and Methods: This hospital-based cross-sectional observational study was conducted from November 2017 to April 2019 in the Department of Paediatrics at Agartala Government Medical College (AGMC), Tripura, India. Total 100 children, from 1 month to 12 years of age, fulfilling definition of AES were enrolled in the study. All the cases were managed as per institutional treatment protocol and were followed-up at one and three months following discharge. Case record, patient profile records and reports of investigations were the study tools. Chi-square test and Fisher's-exact test were used as per applicability to test the significance of difference of proportions using Statistical Package for the Social Sciences (SPSS) version 15.0. The difference was considered significant for a p-value <0.05.

Results: Out of total, 30 patients (30%) were in 9-12 years age group, with slight male preponderance (1.1:1). Total 72 cases (72%) were from rural area. Common clinical features were fever, altered sensorium, seizures, irritability, abnormal movement, pallor, papilloedema, and lethargy. Abnormal laboratory parameters included leucocytosis (62%), anaemia (27%), hyponatremia (35%), and hypoglycaemia (16%) and elevated liver enzymes (15%). Immunoglobulin M (IgM) serology was positive for JEV (19%), scrub typhus (6%), herpes simplex virus (2%), dengue (2%), measles (1%), and enterovirus (1%). Magnetic resonance imaging brain was normal in 37% of the cases. About 54% of the cases recovered completely, 20% of the cases died and remaining 26% survived with sequelae.

Conclusion: The AES is common among older male children from the rural area. Serologically JEV is most common cause. Total 54% cases recovered completely. Proportion of death and residual sequelae were higher in the JEV category. The observations of the study indicate need of extensive studies and scaling up of JE vaccination.

Keywords

Glasgow coma scale, Herpes simplex virus, Japanese encephalitis virus, Varicella-zoster virus

The Acute Encephalitis Syndrome (AES) is defined as acute onset of fever and a change in the mental status (e.g., confusion, disorientation, coma or inability to talk) and/or new onset of seizures (excluding simple febrile seizures) in a person of any age at any time of the year (1). Viruses are the main cause of AES. Japanese Encephalitis Virus (JEV), Herpes Simplex Virus (HSV), Varicella Zoster virus (VZV), Influenza A virus, West Nile virus, Chandipura virus, Mumps, Measles, Dengue, Parvovirus B19, Enteroviruses, Epstein-Barr virus, Nipah virus, Zika virus and Rabies virus, Scrub typhus and Streptococcus pneumoniae are among the other causes of AES in India. Other causes such as bacteria, fungus, parasites (Plasmodium falciparum), spirochetes, and non infectious agents have also been reported. In a large number of AES cases aetiology remains unidentified (2). The incidence of viral encephalitis in children is 3.5-7.4/1,00,000/per year (3). Japanese Encephalitis (JE) is a mosquito borne viral encephalitis occurring in monsoon and post monsoon period in Japan, China, South-east Asia and India causing around 10,000 deaths per year (4).

Acute encephalitis syndrome due to JEV was first diagnosed in 1955 in Tamil Nadu. During 2018, 10485 AES cases and 632 deaths were reported from 17 states like Assam, Bihar, Jharkhand, Karnataka, Manipur, Meghalaya, Tripura, Tamil Nadu, Uttar Pradesh with a case fatality rate of 6% (2),(5). There is no cure for JEV, and many of the children die and rest are left with life threatening sequelae (6). Vaccination and vector control are the ways to protect against JE infection (6).

In India, JE vaccination has been initiated in endemic states and was subsequently included in the National Immunisation Schedule in 2014 (6). Identifying the aetiological agent in AES cases presents a challenge to effective prevention and management (6). There is no study on AES involving paediatrics population of Tripura. So, the present study was conducted to determine the clinical profile and short term outcome (complete recovery, recovery with sequelae, death, referral, sequelae at one month and three months) of AES in children.

Material and Methods

This hospital-based cross-sectional observational study was conducted from November 2017 to April 2019 in the Department of Paediatrics at Agartala Government Medical College (AGMC), Tripura, India. The Institutional Ethical Committee had approved the study {vide letter number F.4(6-9)/AGMC/Academic/IEC Committee/2015}.

Inclusion criteria: All admitted children aged 1 month to 12 years and fulfilling definition of AES (1) were included in the study.

Exclusion criteria: Non consenting parents, patients with non infectious Central Nervous System (CNS) disorders. Children above 12 years are not admitted in Paediatric Ward as per hospital admission policy. Patients with non infectious CNS disorders such as epilepsy, electrolyte imbalance, trauma, vascular and demyelination disorders were excluded from the study (with the help of history, examination and relevant investigations).

Procedure

Case records, patient profile records and investigation reports were the study tools. Management of AES was initiated by assessment of airway, breathing, and circulation. Supplemental oxygen and ventilator support were provided as per requirement. Seizures were treated with anticonvulsants. Patients with shock were managed by intravenous fluids and inotropes. Following stabilisation, detail history was taken and clinical examination was done.

At admission blood samples were collected for complete blood count, Erythrocyte Sedimentation Rate (ESR), blood glucose, malarial parasite, electrolytes and blood culture. Blood sample for IgM viral serology was collected after four days of onset of illness. Lumber puncture was done following stabilisation and after excluding raised Intra Cranial Tension (ICT) by fundoscopy and non contrast computerised tomography of brain. Cerebrospinal fluid was studied for total and differential cell count, protein and sugar, gram staining, culture and Cartridge Based Nucleic Acid Amplification Test (CBNAAT) for Mycobacterium Tuberculosis. Magnetic Resonance Imaging (MRI) of the brain was done in stable patients with focal neurological deficits or worsening Glasgow Coma Scale (GCS). Raised ICT was managed with intravenous mannitol/ dexamethasone/oral glycerol. Temperature was controlled by tepid water sponging and paracetamol. Nutrition was managed by intravenous glucose and/or gavage feeding. Care of eyes, bowel, bladder and skin were extended to all patients. Specific therapy included antibiotics for bacterial meningitis, acyclovir for AES with Herpes Simplex Virus/Varicella Zoster Virus (HSV/VZV) and doxycycline for rickettsial infections. Rehabilitation in the form of physiotherapy, speech therapy etc., was extended to patients with residual disability. Outcome of the patients were recorded in terms of complete recovery, recovery with sequelae and death. Patients were followed-up at one and three months following discharge.

Statistical Analysis

Data were recorded, and analysed with computer using the Statistical Package for the Social Sciences (SPSS) 15.0 software. Raw data were grouped in frequency distribution tables like demographic profile, clinical features, laboratory parameters, outcome of the patients at discharge, outcome at follow-up etc., Contingency tables comparing the demographic profile, clinical features, laboratory parameters and outcome between JE and non JE categories was made. Subsequently, Chi-square test and Fisher’s-exact test were used as per applicability to test the significance of difference of proportions using SPSS version 15. The difference was considered significant for a p-value <0.05.

Results

A total of 100 children were enrolled in the study. Most of the patients (30%) were in 9-12 years age group. Male:female ratio was 1.1:1. Total 72% of the cases were from rural area. About 60% of the cases were among the tribal population and 40% cases were from the rest of the population. However, demographic variables did not differ significantly between the JE and Non JE groups (Table/Fig 1). Number of cases was more between May and August with a peak in July for both JE and Non JE cases (Table/Fig 2).

Common clinical features observed were fever, altered sensorium, seizures, irritability, abnormal movement, pallor, papilloedema and lethargy in order of descending frequency. Proportion of irritability, papilloedema, lethargy and abnormal movements were significantly higher among the JE patients (Table/Fig 3).

Leucocytosis was observed in 62 (62%) and anaemia in 27 (27%) patients. Other laboratory parameters were hypoglycaemia (16%), hyponatremia (35%), hypokalemia (9%) and elevated liver transaminases (17%). Plasmodium falciparum was detected in 14% of the patients (Table/Fig 4).

Cerebrospinal fluid study was done in 80 patients showing increased protein (81%), low glucose (15%), lymphocytosis (11%), neutrophilia (5%) and raised pressure (5%). CSF culture, Ziehl-Neelsen staining and CBNAAT did not demonstrate any pathological agent. In four cases, CSF was suggestive of bacterial meningitis (Table/Fig 4).

The IgM Serology was positive for JE, Scrub typhus, HSV, Dengue, Measles, and Enterovirus in 19%, 6%, 2%, 2%, 1% and 1% of the cases, respectively. In 69% of the cases serology was negative (Table/Fig 4). Among all the laboratory parameters hypoglycaemia and hyponatremia were significantly higher in the JE category.

Magnetic Resonance Imaging (MRI) brain was performed in 35 patients and was found normal in 37.1% of the cases. Bilateral basal ganglia T-2 hyperintensities (25.7%), bilateral temporal lobe T-2 hyperintensities (11.4%), multifocal T-2 hyperintensities (11.4%) were the common findings (Table/Fig 5). However, bilateral basal ganglia lesions were significantly more in the JE category.

Outcome of the patients were recorded as discharged without sequelae (57.4%), discharged with sequelae (14.8%) and death in hospital (27.7%). Six patients were lost from the study (five patients left against medical advice and one patient was referred). Mean hospital stay was calculated to be 9 days. Besides proportion of death and residual sequelae were higher among JE category in comparison to Non JE category but the difference was not significant (Table/Fig 6).

Fourteen patients were discharged with single or multiple sequelae. At discharge 3 (4.4%) patients had hypotonia, 3 (4.4%) had abnormal movements, 8 (11.8%) had speech impairment, 3 (4.4%) had cranial nerve palsy and another 2 (2.9%) had paresis. At 1 month follow-up speech impairments {6 (9.5%)}, abnormal movements and cranial nerve palsy {3 (4.7%)} were the most common residual sequelae. At 3rd month follow-up too, speech impairments {4 (6.5%)}, abnormal movements and cranial nerve palsy {2 (3.2%)} continued to be the most common residual sequelae (Table/Fig 7).

Discussion

This was a prospective cross-sectional study involving 100 children aged 1 month to 12 years with AES admitted as per hospital admission policy in the Department of Paediatrics, AGMC, Tripura.

Majority of the cases were aged 9-12 years suggesting higher incidence of AES in late childhood. Kakoti G et al., (Dibrugarh, India) reported higher incidence among 5-12 years age group (7). A male:female ratio of 1.1:1 was reported by Jain P et al., (Uttar Pradesh, India) (8). It was found that most of the patients were from rural areas (72%). Similar observations were reported by Kakoti G et al., from Assam (7). In this study, number of both JE and non JE AES cases was more between May and August, with a peak in July. A study from Darjeeling, West Bengal, too reported maximum number of cases in July (9).

In this study, fever (100%), altered sensorium (100%), seizures (92%) were the leading clinical features. Kakoti G et al., also reported fever (100%), altered sensorium (83.58%) and seizures (82.08%) as most common (7). In the present study, proportion of irritability, papilloedema, lethargy and abnormal movements were significantly higher among the JE patients. Whereas, Mittal M et al., (Gorakhpur, Uttar Pradesh, India) described significantly higher proportion of headache (25.8% vs 10.74%) in the JE category, and generalised oedema (6.5% vs 24.8%) in the non JE category (10).

Common laboratory findings were leucocytosis (62%), hyponatremia (35%), low haemoglobin (27%), raised SGPT (17%) and raised SGOT (15%). Kumar R et al., (Uttar Pradesh, India) found 15.6% cases had thrombocytopenia, 47.2% had elevated transaminases, 3.3% had elevated blood urea (11). In this study, proportion of hypoglycaemia and hyponatraemia were significantly higher in non JE category. Mittal M et al., (Gorakhpur, Uttar Pradesh) also found higher proportion of hypoglycaemia (4% vs 4.5%), and hyponatraemia (4.2% vs 6%) in non JE category, but the difference was not statistically significant (10).

In this study, CSF analysis of 80 patients showed lymphocytosis in nine, and neutrophilia in four, elevated CSF protein in 65, low CSF glucose in 12, and raised CSF pressure in four patients. CSF study was not done in 20 patients (eight patients were in a critical condition and 12 patients did not give consent). All CSF sample were negative for bacterial culture. Virological studies with CSF were not possible in the study. Kakoti G et al., and Kumar R et al., observed lymphocytosis in 77% and 26% cases and elevated CSF protein in 52.5% and 36% cases, respectively (7),(11).

In the present study, 19% of the patients were seropositive for JE IgM. Jain A et al., observed 16.2% of their patients to be seropositive for JE, 10.8% for Dengue, 9.3% for HSV, 8.9% for measles, 8.7% for mumps, and 4.4% for VZV (12). In present study, 14 cases were positive for Plasmodium falciparum. Deepthi C et al., observed 9.5% of the enrolled patients to have cerebral malaria (13).

In the present study, MRI brain was done in 35 patients. Long waiting time and expense were the limiting factors. Among those who underwent MRI brain, 37% patients had normal findings. Predominantly, bilateral basal ganglia T-2 hyperintensities were found in 26% cases and bilateral temporal lobe T-2 hyperintensities in 11.4% cases, suggesting JE and HSV encephalitis respectively. Ghosh MK et al., observed that MRI brain was normal in 62.9% of the cases. Basal ganglia involvement and cortical involvement were found in 16.1% and 4.5% (14). The difference in observation is likely due to regional variations in aetiologies.

Six patients could not be followed-up, in this study. Of the remaining, 57.4% patients were discharged following complete recovery, 14.8% were discharged with residual sequelae, and remaining 27.7% died. Patients discharged with sequelae had speech impairment, cranial nerve palsies, hypotonia, abnormal movements and paresis. Kakoti G et al., reported that 21.13% JE patients had neurological sequelae at discharge, while 14.7% had died in the hospital (7). Kumar R et al., reported 66.7% children with JE had dystonia (11). Avabratha KS et al., reported 40.85% of the cases recovered completely and others had speech disturbance (47.61%), motor deficits, behavioural disturbance, involuntary movements, and seizures (15) (Table/Fig 8) (7),(9),(10),(13),(15).

All discharged patients (68) were followed-up at one and at three months. Five of them were lost to follow-up at one month. Out of 63 patients followed-up at one month, two recovered, 9.5% had speech impairment, 4.8% had abnormal movements, 4.8% had cranial nerve palsy, 3.2% had hypotonia and 3.2% had paresis. Two patients were lost to follow-up at three month. Of the remaining, only one patient improved and the rest had persistent sequelae like speech impairment (6.6%), abnormal movements and cranial nerve palsy (3.3% each). Avabratha KS et al., reported motor deficits and speech disturbances in 25.68% and 22.01% cases, respectively, at one year follow-up (15). Ooi MH et al., followed-up enrolled patients for a median duration of 52.9 months. During follow-up, 31 patients experienced improvement but 15 patients deteriorated. More than half of the patients had residual neurological sequelae and behavioural disorders (16).

In this study, proportion of death and residual sequelae were higher among the JE category. Verma A et al., reported similar observation (17). Extent and duration of sequelae varied between studies possibly due to differences in the extent of neurological damage.

Limitation(s)

This single centre small sized observational study has its inherent limitations. Besides because of technical difficulties examination of paired sera, comparison on the basis of immunisation status and MRI brain for all cases could not be done. All these add to its limitations. However, the observations in the study demands further extensive studies in this field and scaling up of JE vaccination in the state.

Conclusion

Acute encephalitis syndrome is common among 9-12 years, male children from the rural area. Serologically, JE was the most common cause found in this study. Fever, altered sensorium and seizure were present in almost all patients. Leucocytosis, hyponatremia, raised transaminases and low haemoglobin were most commonly encountered laboratory findings. One out of three patients had normal neuroimaging. Total 54% cases recovered completely. Proportion of death and residual sequelae were higher in the JE category. These observations of the study indicate need of further extensive studies and scaling up of JE vaccination.

References

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DOI and Others

DOI: 10.7860/JCDR/2022/51692.16111

Date of Submission: Aug 03, 2021
Date of Peer Review: Sep 27, 2021
Date of Acceptance: Jan 03, 2022
Date of Publishing: Mar 01, 2022

AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA

PLAGIARISM CHECKING METHODS: [Jain H et al.]
• Plagiarism X-checker: Aug 04, 2021
• Manual Googling: Dec 24, 2021
• iThenticate Software: Jan 18, 2022 (8%)

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