Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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On Sep 2018

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"Journal of Clinical and Diagnostic Research is at present a well-known Indian originated scientific journal which started with a humble beginning. I have been associated with this journal since many years. I appreciate the Editor, Dr. Hemant Jain, for his constant effort in bringing up this journal to the present status right from the scratch. The journal is multidisciplinary. It encourages in publishing the scientific articles from postgraduates and also the beginners who start their career. At the same time the journal also caters for the high quality articles from specialty and super-specialty researchers. Hence it provides a platform for the scientist and researchers to publish. The other aspect of it is, the readers get the information regarding the most recent developments in science which can be used for teaching, research, treating patients and to some extent take preventive measures against certain diseases. The journal is contributing immensely to the society at national and international level."

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Dr. Mamta Gupta,
"It gives me great pleasure to be associated with JCDR, since last 2-3 years. Since then I have authored, co-authored and reviewed about 25 articles in JCDR. I thank JCDR for giving me an opportunity to improve my own skills as an author and a reviewer.
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Reviewing articles is no less a pain staking process and requires in depth perception, knowledge about the topic for review. It requires time and concentration, yet I enjoy doing it. The JCDR website especially for the reviewers is quite user friendly. My suggestions for improving the journal is, more strict review process, so that only high quality articles are published. I find a a good number of articles in Obst. Gynae, hence, a new journal for this specialty titled JCDR-OG can be started. May be a bimonthly or quarterly publication to begin with. Only selected articles should find a place in it.
An yearly reward for the best article authored can also incentivize the authors. Though the process of finding the best article will be not be very easy. I do not know how reviewing process can be improved. If an article is being reviewed by two reviewers, then opinion of one can be communicated to the other or the final opinion of the editor can be communicated to the reviewer if requested for. This will help one’s reviewing skills.
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Aug 2018

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Salient features of the JCDR: It is a biomedical, multidisciplinary (including all medical and dental specialities), e-journal, with wide scope and extensive author support. At the same time, a free text of manuscript is available in HTML and PDF format. There is fast growing authorship and readership with JCDR as this can be judged by the number of articles published in it i e; in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. This e-journal is fulfilling the commitments and objectives sincerely, (as stated by Editor-in-chief in his preface to first edition) i e; to encourage physicians through the internet, especially from the developing countries who witness a spectrum of disease and acquire a wealth of knowledge to publish their experiences to benefit the medical community in patients care. I also feel that many of us have work of substance, newer ideas, adequate clinical materials but poor in medical writing and hesitation to submit the work and need help. JCDR provides authors help in this regards.
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In the era of fast growing newer technologies, and in computer and internet friendly environment the manuscripts preparation, submission, review, revision, etc and all can be done and checked with a click from all corer of the world, at any time. Of course there is always a scope for improvement in every field and none is perfect. To progress, one needs to identify the areas of one's weakness and to strengthen them.
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Every one of us: authors, reviewers, editors, and publisher are responsible for enhancing the stature of the journal. I wish for a great success for JCDR."

Thanking you
With sincere regards
Dr. Rajendra Kumar Ghritlaharey, M.S., M. Ch., FAIS
Associate Professor,
Department of Paediatric Surgery, Gandhi Medical College & Associated
Kamla Nehru & Hamidia Hospitals Bhopal, Madhya Pradesh 462 001 (India)
On May 11,2011

Dr. Shankar P.R.

"On looking back through my Gmail archives after being requested by the journal to write a short editorial about my experiences of publishing with the Journal of Clinical and Diagnostic Research (JCDR), I came across an e-mail from Dr. Hemant Jain, Editor, in March 2007, which introduced the new electronic journal. The main features of the journal which were outlined in the e-mail were extensive author support, cash rewards, the peer review process, and other salient features of the journal.
Over a span of over four years, we (I and my colleagues) have published around 25 articles in the journal. In this editorial, I plan to briefly discuss my experiences of publishing with JCDR and the strengths of the journal and to finally address the areas for improvement.
My experiences of publishing with JCDR: Overall, my experiences of publishing withJCDR have been positive. The best point about the journal is that it responds to queries from the author. This may seem to be simple and not too much to ask for, but unfortunately, many journals in the subcontinent and from many developing countries do not respond or they respond with a long delay to the queries from the authors 1. The reasons could be many, including lack of optimal secretarial and other support. Another problem with many journals is the slowness of the review process. Editorial processing and peer review can take anywhere between a year to two years with some journals. Also, some journals do not keep the contributors informed about the progress of the review process. Due to the long review process, the articles can lose their relevance and topicality. A major benefit with JCDR is the timeliness and promptness of its response. In Dr Jain's e-mail which was sent to me in 2007, before the introduction of the Pre-publishing system, he had stated that he had received my submission and that he would get back to me within seven days and he did!
Most of the manuscripts are published within 3 to 4 months of their submission if they are found to be suitable after the review process. JCDR is published bimonthly and the accepted articles were usually published in the next issue. Recently, due to the increased volume of the submissions, the review process has become slower and it ?? Section can take from 4 to 6 months for the articles to be reviewed. The journal has an extensive author support system and it has recently introduced a paid expedited review process. The journal also mentions the average time for processing the manuscript under different submission systems - regular submission and expedited review.
Strengths of the journal: The journal has an online first facility in which the accepted manuscripts may be published on the website before being included in a regular issue of the journal. This cuts down the time between their acceptance and the publication. The journal is indexed in many databases, though not in PubMed. The editorial board should now take steps to index the journal in PubMed. The journal has a system of notifying readers through e-mail when a new issue is released. Also, the articles are available in both the HTML and the PDF formats. I especially like the new and colorful page format of the journal. Also, the access statistics of the articles are available. The prepublication and the manuscript tracking system are also helpful for the authors.
Areas for improvement: In certain cases, I felt that the peer review process of the manuscripts was not up to international standards and that it should be strengthened. Also, the number of manuscripts in an issue is high and it may be difficult for readers to go through all of them. The journal can consider tightening of the peer review process and increasing the quality standards for the acceptance of the manuscripts. I faced occasional problems with the online manuscript submission (Pre-publishing) system, which have to be addressed.
Overall, the publishing process with JCDR has been smooth, quick and relatively hassle free and I can recommend other authors to consider the journal as an outlet for their work."

Dr. P. Ravi Shankar
KIST Medical College, P.O. Box 14142, Kathmandu, Nepal.
On April 2011

Dear team JCDR, I would like to thank you for the very professional and polite service provided by everyone at JCDR. While i have been in the field of writing and editing for sometime, this has been my first attempt in publishing a scientific paper.Thank you for hand-holding me through the process.

Dr. Anuradha
On Jan 2020

Important Notice

Original article / research
Year : 2022 | Month : March | Volume : 16 | Issue : 3 | Page : YC12 - YC15 Full Version

Effects of Progressive Gaze Stability Exercises on Balance and Gait in Vestibular Neuritis Patients: A Quasi-experimental Study

Published: March 1, 2022 | DOI:
Priya Chauhan, SD Shahanawaz, Gaurav Kapoor

1. Assistant Professor, Department of Physiotherapy, Chandigarh University, Mohali, Punjab, India. 2. Assistant Professor, Department of Physiotherapy, College of Applied Medical Sciences, University of Hail, Saudi Arabia. 3. PhD Scholar, Department of Physiotherapy, Jayoti Vidyapeeth Women’s University, Jaipur, Rajasthan, India.

Correspondence Address :
Dr. Priya Chauhan,
Assistant Professor, Department of Physiotherapy, Chandigarh University, Gharuah, Mohali, Punjab, India.


Introduction: Gaze stability exercises are the exercises that are used effectively to improve gaze stability during head movement in various vestibular disorders patients, and to improve balance in static and dynamic movements of the same.

Aim: To compare the effectiveness of progressive gaze stability exercises to improve balance and gait in patients with vestibular neuritis.

Materials and Methods: This quasi-experimental study was conducted at Outpatient Department of SGT hospital, Gurugram, Haryana, India, from November 2018 to March 2019. A total of 26 subjects were randomly assigned into two groups, group A received progressive gaze stability exercises with conventional therapy (n=13) and group B received conventional therapy (n=13). Group A received Vestibular Rehabilitation Therapy (VRT) for 25 minutes a day five times a week for four weeks. group B conventional training which consisted of balance exercises. Participants were assessed with Mini Balance Evaluation Systems Test (Mini-BESTest) and dizziness handicap inventory to access the performance of balance and functional limitation, respectively. Data was analysed by using the Statistical Package for the Social Sciences (SPSS) version 20.0 for statistical analysis. A level of significance was set at p-value <0.05.

Results: The finding of the study showed no significant change for baseline parameters between the experimental and conventional groups with respect to age (p-value=0.097), gender (p-value=0.573), height (p-value=0.682), weight (p-value=0.945), duration of illness (p-value=0.579). Both the groups showed significant improvement with in group, when measured using dependent t-test for Mini-BESTest and Wisconsin Gait Scale. The comparison of postintervention scores of Mini-BESTest and WGS between group A and group B showed significant difference (p-value=0.001) and (p-value=0.002) respectively.

Conclusion: The present study has provided preliminary evidence that progressive gaze stability exercises when coupled with conventional balance exercises may improve gait and balance in patients with vestibular neuritis.


Adaptation exercises, Postural training, Substitution exercises, Vestibular rehabilitation

Vestibular neuritis is a disorder resulting most commonly from a viral infection that inflames the inner ear or the nerves connecting the inner ear to the brain (1). This inflammation results in disruption of the transmission of sensory information from the ear to the brain which leads to sudden, severe vertigo (a spinning sensation) caused by altered processing of information from both the ears. Other symptoms include dizziness, nausea, vomiting, imbalance, leading to significant difficulty in walking (2). The average annual incidence of vertigo varied from 11.7 per 1,00,000 in the year 2012 to 16.1 in the year 2017, with the mean age at the onset of the disease as 52.3 years and male to female ratio as 1.1:1 (3).

Balance is the ability to maintain equilibrium, the input from different receptors, including labyrinthine, somatosensory, and visual are fed to the feedback circuits which are responsible for body balance. To correct internal and external balance perturbations, these inputs have to be adequately integrated within the central nervous system in order to produce appropriate changes in motor output and if any input gets impaired, the balance gets hampered. Vestibular neuritis affects the vestibular organs which includes the three loop-shaped semicircular canals affecting the sac-shaped utricle and saccule. They provide signal to the brain via the vestibulocochlear nerve (eighth cranial nerve). This nerve has two branches. First branch which is known as the cochlear nerve transmits messages from the hearing organ, while the second known as the vestibular nerve transmits messages from the balance organs (4). Vestibular neuritis occurs due to sudden decrease in the function of one set of vestibular organs mainly from one inner ear. It is believed that our two ears constantly send information to the brain about the status of our balance. The brain which integrates those signals sent from the right and the left ear so when one ear stops sending the signals, the brain receives signals from the healthy side and interprets rotating movement of the body. As a compensation for this false sense of rotation, the brain generates eye and body movements in the opposite direction, which causes a strong sensation of spinning, nausea and a tendency to fall to one side (5).

Numerous interventions such as optokinetic training and sensitisation have been used to treat various vestibular disorders there is insufficient research on interventions for vestibular neuritis, which causes patients to lose their balance (6). There are various rehabilitation techniques that have been adopted to improve gait and balance parameters in vestibular neuritis patients. Progressive gaze stability exercises are the exercises that focus on the plasticity of the balance system by promoting vestibular adaptation and substitutions to improve compensations (7). No study documented the effectiveness of progression of gaze stability exercises on postural stability and dizziness occurring due to viral infections leading to acute neuritis. Hence, the aim of this study was to investigate the effect of progressive gaze stability exercises compared with conventional balance training on balance and gait in patients with vestibular neuritis.

Material and Methods

This quasi-experimental study was conducted at Outpatient Department of SGT hospital, Gurugram, Haryana, India, from November 2018 to March 2019. This study was approved by the Institute Ethics Committee (SGTU/ FMHS/D/108), and the review board of SGT University, Gurugram, Haryana, India.

Inclusion criteria: The inclusion was typically based on clinical history and physical examination in accordance to the four established criteria for vestibular neuritis: 1) acute or sub-acute onset of vertigo; 2) horizontal spontaneous nystagmus with a fast-phase component toward the unaffected ear; 3) hyporesponsive biothermal caloric test results in the affected ear (with greater than 25% asymmetry between the sides, as measured with Jongkees’s formula (8); and 4) displacement of verticality as perceived with eyes when rotated toward the affected ear without any vertical divergence of an eye above other (9),(10).

Exclusion criteria: Patients having labyrinthitis, retrocochlear lesion, Meniere’s disease, migraine associated vertigo, transient ischemic attack, and infarction or haemorrhages of either the inner ear or the brain stem, or with other neurological or psychiatric illness were excluded from the study.

A total of 26 patients were included who were diagnosed with vestibular neuritis by physicians, computed tomography, and/or an Magnetic Resonance Imaging (MRI) scan of the brain with contrast can show enhancement of the vestibular nerve fibres within the internal auditory canal with the labyrinth of the inner ear often intact.

Study Procedure

Each participant provided their written informed consent. A total of 26 subjects were randomly assigned into two groups,

• Group A vestibular rehabilitation with conventional therapy (n=13);
• Group B placebo along with conventional therapy (n=13) only.

Each group received Vestibular Rehabilitation Therapy (VRT) or placebo training 25 minutes in a day five times in a week for four weeks. Patients were assigned randomly to the experimental and control groups using computer-generated random number system.

Experimental procedure (group A): The vestibular rehabilitation program consisted of 25 minutes of vestibular adaptation exercises which consist of gaze stability exercises. It comprised of various exercises that are performed rapidly with active head rotations. The visual target was fixed or moving depending on the type of exercises to be performed. The individual was asked to perform the head movements. The patients were asked to do head motions with a fixed visual target, which were referred to as X1 viewing exercises. The X2 viewing exercises were defined as those in which the visual target moved in the opposite direction of the head (11).

Placebo procedure (Group B): The placebo program consisted of exercises that were performed to be vestibular neutral exercises. It comprised of exercises in which the participants performed saccadic eye movements, with the head stationary without holding on visual targets against a plain white wall. The time taken to perform these placebo eye exercises was equated with the time spent by Group A in performing gaze stability exercises. All the participants were instructed to perform the exercises over a period of four weeks 25 minutes in a day for five days over a four week period. After fourth week, postintervention data was collected again to analyse the statistical differences (12).

Wisconsin Gait Scale (WGS) is an observational tool for the evaluation of gait. It is divided into four subscales. which assess a total of fourteen spatiotemporal and kinematic parameters of gait observed during the consecutive gait phases (13).

Participants were assessed with Mini Balance Evaluation Systems Test (Mini-BESTest) and dizziness handicap inventory to access the performance of balance and functional limitation, respectively. The Mini-BESTest was used to assess balance in several neurological conditions. It was widely used in both clinical practice and research. It includes 14 items and maximum score of 28 points. Each score from 0-2 (14).

Conventional Training

Both the groups received a conventional therapy program for 45 minutes a day, five days in a week for four weeks, along with experimental and placebo training. Conventional training consisted balance and gait exercises.

Balance exercises:

(a) Standing with feet shoulder width apart arms across the chest and the patient was asked to bring the feet closer together with closed eyes on cushion sofa or foam;
(b) Practiced ankle sways, medial-lateral and anterior-posterior later on with circle sways with closed eyes;
(c) Attempted to walk with heel touching toe on firm surface and then on carpet;
(d) Practiced walking five steps and turning 180 (left and right);
(e) Walked and moved the head side to side, up and down;
(f) Touched the wall;
(g) Took a ball in hand, lifted it up, transferred to other hand followed arch visually.

Gait exercises:

(a) Walking on straight line;
(b) Walking with head in motion;
(c) Walking with head turns;
(d) Sit to stand;
(e) Standing with one foot;
(f) Standing on cushion;
(g) Standing and throwing;
(h) Standing with heel together;
(i) Standing on one feet, all exercises were performed under the supervision of a physiotherapist (15).

Statistical Analysis

Data was analysed by using the Statistical Package for the Social Sciences (SPSS) version 20.0 for statistical analysis. After the descriptive analysis of the data the Shapiro-Wilk test was used to assess the normality of the data distribution. As variables were shown to be parametric, student t-test was used to compare variables within each group and for comparisons between the groups paired t-test was used to analyse within group differences. A level of significance was set at p-value ≤0.05.


The general characteristics of the study participants are summarised in (Table/Fig 1). There was no significance difference found between characteristics of participants in group A and group B in terms of age (p-value=0.097), height (p-value=0.682), weight (p-value=0.945), duration of illness (p-value=0.579), gender score at baseline.

On comparing the pre-intervention scores of group A and B for Mini-BESTest (p-value=0.132) and WGS (p-value=0.215) no significant difference was seen. However, the comparison of postintervention scores of Mini-BESTest and WGS between group A and group B showed significant difference (p-value=0.001) and (p-value=0.002) respectively as measured by students t-test shown in (Table/Fig 2).


The present study findings indicate that gaze stability exercises can bring about a significant improvement on balance in patients with vestibular neuritis. This study is in accordance with the study conducted by Goudakos JK et al., who reported the benefit of various vestibular exercises to facilitate reflex mechanism related to vestibular function (16). Vestibular Rehabilitation focuses on utilising the plasticity of the balance system to improve the natural compensation process. Decreased gain of vestibular response to head movements gives rise to gaze instability in patients with vestibular dysfunction (17). Inducing retinal slip by horizontal or vertical head movements while maintaining visual fixation on a target, increases the gain of the vestibular response (18),(19). For vestibular adaptation to occur, retinal slip needs to be induced repeatedly.

The findings of this study are similar to thar conducted by Macias JD et al., in which there was a statistical significant improvement on the scores of Berg Balance Scale (BBS) after vestibular rehabilitation therapy (20). Another study by Giray M et al., also showed improvement in BBS scores after vestibular rehabilitation in chronic unilateral vestibular dysfunction (21).

In a similar study, Gans RE concluded that there are various compensatory responses of the central nervous system which are based on plasticity of the brain therefore when we use motion sensitive exercises their occurs habituation a repetitive stimuli which in turn leads to a rebalance in the tonic activity within the vestibular nuclei. He also suggested that sensory conflict might lead to neurological rearrangements known as vestibular compensation on which vestibular training is based (22).

Cohen HS et al., suggested that VRT is important to co-ordinate learning strategies to maximise adaptation, motor learning and avoid overstimulation. Therefore, it is critical for a clinician to pay more attention to not only the common vestibular symptom but also gait stabilisation to avoid fall, and further to improve balance. Eye and head movements exercises are performed to improve the gaze stability, whereas exercises performed while sitting, standing on firm or cushion or on narrow base to improve postural stability (23).

The Vestibulo-Ocular Reflex (VOR) is activated while gazing on a target during head rotation and to maintain one’s posture. The VOR function directly affects gait performance and its evaluation can assess the people who are at higher risk of falling. The principle of VOR training is also based on sensory conflict which might lead to various neurological rearrangements, commonly called as vestibular compensations, which consists of gaze stabilisation and balance exercises (24),(25),(26),(27). Gaze stability exercises increase gain of vestibular response to head movements thus in turn gives rise to stability. They also induce retinal slip thereby inducing vestibular adaptation by horizontal and vertical head movements while focusing on fixed target and in turn increases vestibular responses (28).


The present study was a preliminary investigation which involved a small sample population. Further studies which involve higher sample size are needed to confirm these results. Furthermore, the duration of treatment was four weeks which might have been insufficient to promote an optimal response for gait for our participants. It remains unknown that whether additional benefits can be obtained when this study is carried out with a longer treatment period. Future studies can be done to investigate the possible carryover effects of the therapy.


The present study has provided preliminary evidence that progressive gaze stability exercises when coupled with conventional balance exercises may improve gait and balance in people with vestibular neuritis. Improvements were shown in Mini-BESTest and WGS scores.


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DOI and Others

DOI: 10.7860/JCDR/2022/51238.16145

Date of Submission: Jul 06, 2021
Date of Peer Review: Sep 22, 2021
Date of Acceptance: Jan 28, 2022
Date of Publishing: Mar 01, 2022

• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. NA

• Plagiarism X-checker: Dec 15, 2021
• Manual Googling: Jan 27, 2022
• iThenticate Software: Feb 01, 2022 (19%)

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